Publications by authors named "Jason Z Zhang"

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Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling.
Jason Z Zhang, Tsan-Wen Lu, Lucas M Stolerman, Brian Tenner, Jessica R Yang, Jin-Fan Zhang, Martin Falcke, Padmini Rangamani, Susan S Taylor, Sohum Mehta

Cell· September 2020

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design of phospho-tyrosine peptide binders.
Magnus S Bauer, Jason Z Zhang, Kejia Wu, Gyu Rie Lee, Brian Coventry

bioRxiv· September 2025

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Diffusing protein binders to intrinsically disordered proteins.
Caixuan Liu, Kejia Wu, Hojun Choi, Hannah L Han, Xueli Zhang, Jason Z Zhang

Nature· August 2025

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SegUnXt+: A High-Performance Deep Learning Model for Thyroid Segmentation in Fully Automatic 3D USE Robotic Examination System.
Ye-Jiao Mao, Wenbo Gao, Minxin Chen, Andy Yiu-Chau Tam, Jason Zhishen Zhang

Annu Int Conf IEEE Eng Med Biol Soc· July 2025

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design of miniprotein agonists and antagonists targeting G protein-coupled receptors.
Edin Muratspahić, David Feldman, David E Kim, Xiangli Qu, Ana-Maria Bratovianu, Jason Z Zhang

bioRxiv· June 2025

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De novo designed Hsp70 activator dissolves intracellular condensates.
Jason Z Zhang, Nathan Greenwood, Jason Hernandez, Josh T Cuperus, Buwei Huang

Cell Chem Biol· March 2025

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Designed endocytosis-inducing proteins degrade targets and amplify signals.
Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Jason Z Zhang

Nature· February 2025

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design of Ras isoform selective binders.
Jason Z Zhang, Xinting Li, Alexa Rane Batingana, Caixuan Liu, Hanlun Jiang

bioRxiv· February 2025

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Single-cell sensor analyses reveal signaling programs enabling Ras-G12C drug resistance.
Jason Z Zhang, Shao-En Ong, David Baker, Dustin J Maly

Nat Chem Biol· January 2025

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Computationally designed sensors detect endogenous Ras activity and signaling effectors at subcellular resolution.
Jason Z Zhang, William H Nguyen, Nathan Greenwood, John C Rose, Shao-En Ong

Nat Biotechnol· December 2024

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Computational design of non-porous pH-responsive antibody nanoparticles.
Erin C Yang, Robby Divine, Marcos C Miranda, Andrew J Borst, Will Sheffler, Jason Z Zhang

Nat Struct Mol Biol· September 2024

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The impact of high-order features on performance of radiomics studies in CT non-small cell lung cancer.
Gary Ge, Jason Z Zhang, Jie Zhang

Clin Imaging· September 2024

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Strategies for improving the performance of prediction models for response to immune checkpoint blockade therapy in cancer.
Tiantian Zeng, Jason Z Zhang, Arnold Stromberg, Jin Chen, Chi Wang

BMC Res Notes· April 2024

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A comparative study of clustering methods on gene expression data for lung cancer prognosis.
Jason Z Zhang, Chi Wang

BMC Res Notes· November 2023

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Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistance.
Jason Z Zhang, Shao-En Ong, David Baker, Dustin J Maly

bioRxiv· October 2023

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designed Hsp70 activator dissolves intracellular condensates.
Jason Z Zhang, Nathan Greenwood, Jason Hernandez, Josh T Cuperus, Buwei Huang

bioRxiv· September 2023

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Designed Endocytosis-Triggering Proteins mediate Targeted Degradation.
Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Jason Z Zhang

bioRxiv· September 2023

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Computational design of non-porous, pH-responsive antibody nanoparticles.
Erin C Yang, Robby Divine, Marcos C Miranda, Andrew J Borst, Will Sheffler, Jason Z Zhang

bioRxiv· April 2023

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De novo design of luciferases using deep learning.
Andy Hsien-Wei Yeh, Christoffer Norn, Yakov Kipnis, Doug Tischer, Samuel J Pellock, Jason Z Zhang

Nature· February 2023

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Thermodynamically coupled biosensors for detecting neutralizing antibodies against SARS-CoV-2 variants.
Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaitlin R Sprouse

Nat Biotechnol· September 2022

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Deep learning versus iterative reconstruction on image quality and dose reduction in abdominal CT: a live animal study.
Jason Z Zhang, Halemane Ganesh, Flavius D Raslau, Rashmi Nair, Edward Escott, Jie Zhang

Phys Med Biol· July 2022

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Liquid-liquid phase separation: a principal organizer of the cell's biochemical activity architecture.
Jason Z Zhang, Sohum Mehta, Jin Zhang

Trends Pharmacol Sci· October 2021

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Protocol for using fluorescent sensors targeted to endogenous proteins (FluoSTEPs) to measure microdomain-specific signaling events.
Jason Z Zhang, Brian Tenner, Sohum Mehta, Jin Zhang

STAR Protoc· September 2021

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Detection of antibodies neutralizing historical and emerging SARS-CoV-2 strains using a thermodynamically coupled de novo biosensor system.
Jason Z Zhang, Hsien-Wei Yeh, Alexandra C Walls, Basile I M Wicky, Kaiti Sprouse

bioRxiv· June 2021

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Characterizing protein kinase A (PKA) subunits as macromolecular regulators of PKA RIα liquid-liquid phase separation.
Surl-Hee Ahn, Sanbo Qin, Jason Z Zhang, J Andrew McCammon, Jin Zhang

J Chem Phys· June 2021

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FluoSTEPs: Fluorescent biosensors for monitoring compartmentalized signaling within endogenous microdomains.
Brian Tenner, Jason Z Zhang, Yonghoon Kwon, Veronica Pessino, Siyu Feng, Jin Zhang

Sci Adv· May 2021

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