Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and is sequestered into membraneless organelles formed by a regulatory subunit of PKA, important for suppressing tumorigenic signaling. https://t.co/xDLohhPb1K https://t.co/jaG5tFP5WF
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling.
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Aug 2020 – Aug 2025Where it's discussed
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X / Twitter102 posts
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AI synopsis
What people are saying
Discussions about the article range from expressions of excitement about its findings to explanations of its relevance in cancer signaling. For example, users frequently mention terms like 'new player in compartmentation' and 'important for suppressing tumorigenic signaling,' which show deep consideration and understanding of the research. The tone is predominantly enthusiastic, with many users highlighting the potential transformative effects of these findings in cancer studies.
Many discussions express a positive reception of the findings and their implications.
There is a strong curiosity about the mechanisms involved, indicating high interest in the topic.
Several posts delve into specific aspects of liquid-liquid phase separation, demonstrating deep engagement with the research.
Contributors highlight the study's relevance to cancer research, suggesting it has significant implications for the field.
Abstract in brief
- The study uncovers that the regulatory subunit of PKA, known as RI, can undergo liquid-liquid phase separation (LLPS) in response to cAMP signaling, forming specialized clusters that enhance cAMP compartmentation and PKA activity.
- The research also uncovers that a cancer-associated PKA fusion protein disrupts RI LLPS, leading to abnormal cAMP signaling and increased cell growth.
- This indicates that LLPS is crucial for maintaining proper signaling architecture, and its dysregulation could contribute to the development of cancer.
Top posts
Most liked on X and BlueskyPhase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Now online! https://t.co/g1vfZCQSPD https://t.co/XwPWKLO6KF
Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Out now! https://t.co/gkESxKlsbQ @jinzhanglab @UCSDnews https://t.co/O6ZTv9bKzK
New Article online now at Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/d6x8hTvdER
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/29tVsUj7k7
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/Sv5xnzbKRo
All mentions
Phase Separation and Oncogenic Signaling in PKA Regulatory Subunit
This supplementary video presents research on the role of the PKA regulatory subunit RI in cAMP signaling. The study reveals how RI undergoes liquid-liquid phase separation, which is essential for cAMP compartmentation…
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@jsauce7 @THebertMcGill I don't know if it's thought recent, but this sounds like an idea (although it may be a question of whether it explains everything) https://t.co/yIljVjZE3m
Super cool paper from @jinzhanglab speaking at the #IOW. 2020 but I had not read it: "Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and #Oncogenic #Signaling" Glad to discover it! #cellbiochemistry https://t.co/2jbLv59bFK
If you want to learn more about PKA liquid-liquid phase separation, you can find our Cell paper here (no longer behind paywall for University of California!)
RT @CellPressNews: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. https://t.co/1L…
Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. https://t.co/1LrTWJGMYc @jinzhanglab @UCSDnews #cellbio2020 https://t.co/3GYmh7w5rt
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/kx48c6KVAT #nor論文
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Out now! https:…
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Out now! https:…
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Out now! https:…
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Out now! https:…
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling: Cell https://t.co/Ouer4KJdob
Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Out now! https://t.co/gkESxKlsbQ @jinzhanglab @UCSDnews https://t.co/O6ZTv9bKzK
Article in this issue of Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling - https://t.co/d6x8hTMP3r
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Now online! htt…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @the_paper_link: Trend up+26: **Zhang JZ** et al (Cell) __Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation an…
Trend up+26: **Zhang JZ** et al (Cell) __Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling__ https://t.co/PmTkYnMhQz
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling - from @jasonzxzhang et al. https://t.co/oFYQqcHh7p
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Now online! htt…
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Now online! htt…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @CellCellPress: Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Now online! htt…
RT @FrezzaLab: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/Sv5xnzbKRo
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/Sv5xnzbKRo
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
Phase #separation of a PKA regulatory #subunit controls cAMP compartmentation and #oncogenic #signaling. Now online! https://t.co/g1vfZCQSPD https://t.co/XwPWKLO6KF
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/tVSc3vuVTB #Fibrolamellar https://t.co/f4vByAgQ49
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @BadrillaLtd: New player in compartmentation of cAMP signalling, liquid-liquid phase separation https://t.co/CUW9oIQhvZ
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
New player in compartmentation of cAMP signalling, liquid-liquid phase separation https://t.co/CUW9oIQhvZ
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/MX4osIHKwo
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/538VxfNCzj PKAの制御サブユニットは相分離し、cAMPを区画化してシグナル伝達に寄与する。発癌に関わるPKAの融合タンパク質では相分離が起きず異常なシグナルと増殖を導くとのこと
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @CellCellPress: New Article online now at Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogeni…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @CellCellPress: New Article online now at Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogeni…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @ShorterLabGroup: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/29tVs…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/hlf7jSj40N
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling: Cell https://t.co/uiiqGsRO7C
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/29tVsUj7k7
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @CellCellPress: New Article online now at Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogeni…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
RT @jinzhanglab: Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and…
Out in @CellCellPress! Our collaborative team @jasonzxzhang @RangamaniUCSD & Susan Taylor discovered that cAMP induces and is sequestered into membraneless organelles formed by a regulatory subunit of PKA, important for suppressing tumorigenic signaling. https://t.co/xDLohhPb1K https://t.co/jaG5tFP5WF
5 years of work is now published in Cell! Going from basic discovery to disease impact (cancer), this work has been quite a collaborative journey! https://t.co/GpEcnrvd8d https://t.co/TgfkXvwhvw
RT @CellCellPress: New Article online now at Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogeni…
RT @CellCellPress: New Article online now at Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogeni…
New Article online now at Cell: Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling https://t.co/d6x8hTvdER