Publications by authors named "Jay Groves"

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Single-molecule biophysics in signaling: Functionality from stochastic effects.
Jay T Groves

Curr Opin Cell Biol· December 2025

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A unifying model of LAT condensates in reconstitution experiments.
Yannick A D Omar, Simou Sun, Mehran Kardar, Jay T Groves, Arup K Chakraborty

bioRxiv· November 2025

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T cell costimulatory and inhibitory signals di4erentially modulate LAT condensate nucleation propensity after TCR ligation.
Saehyun Choi, Sungi Kim, Jessica Tijham, Timothy Eisen, Shumpei Morita, Jay T Groves

bioRxiv· November 2025

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Parallel reactions on a single T cell receptor offer a robust kinetic proofreading mechanism.
Shumpei Morita, Jay T Groves

Proc Natl Acad Sci U S A· October 2025

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BTK autoinhibition analyzed by high-throughput swaps of SH2 domains.
Timothy J Eisen, Sam Ghaffari-Kashani, Chien-Lun Hung, Jay T Groves, John Kuriyan

Proc Natl Acad Sci U S A· October 2025

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Bacterial XopR subverts RIN4 complex-mediated plant immunity via plasma membrane-associated percolation.
Xinlu Zhu, Weibing Wang, Simou Sun, Choon-Peng Chng, Yi Xie, Jay T Groves

Dev Cell· August 2025

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Autophosphorylation of oncoprotein TEL-ABL in myeloid and lymphoid cells confers resistance to the allosteric ABL inhibitor asciminib.
Serena Muratcioglu, Christopher A Eide, Chien-Lun Hung, Kent Gorday, Emily Sumpena, Jay T Groves

Sci Signal· July 2025

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Proofreading and single-molecule sensitivity in T cell receptor signaling by condensate nucleation.
William L White, Hailemikael K Yirdaw, Ariel J Ben-Sasson, Jay T Groves, David Baker

Proc Natl Acad Sci U S A· June 2025

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Kinetic Proofreading through Parallel Reactions on a Single T Cell Receptor.
Shumpei Morita, Jay T Groves

bioRxiv· June 2025

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Conditional requirement for dimerization of the membrane-binding module for BTK signaling in lymphocyte cell lines.
Timothy J Eisen, Sam Ghaffari-Kashani, Chien-Lun Hung, Jay T Groves, Arthur Weiss

Sci Signal· January 2025

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Direct imaging with multidimensional labelling and high-content analysis allows quantitative categorization and characterizations of individual small extracellular vesicles and nanoparticles (sEVPs).
Simou Sun, Sarah J Cox-Vázquez, Nam-Joon Cho, Guillermo C Bazan, Jay T Groves

J Extracell Vesicles· December 2024

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Positive feedback in Ras activation by full-length SOS arises from autoinhibition release mechanism.
He Ren, Albert A Lee, L J Nugent Lew, Joseph B DeGrandchamp, Jay T Groves

Biophys J· October 2024

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Differential roles of kinetic on- and off-rates in T-cell receptor signal integration revealed with a modified Fab'-DNA ligand.
Kiera B Wilhelm, Anand Vissa, Jay T Groves

Proc Natl Acad Sci U S A· September 2024

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Discrete protein condensation events govern calcium signal dynamics in T cells.
Shumpei Morita, Mark K O'Dair, Jay T Groves

bioRxiv· July 2024

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Bimodality in Ras signaling originates from processivity of the Ras activator SOS without deterministic bistability.
Albert A Lee, Neil H Kim, Steven Alvarez, He Ren, Joseph B DeGrandchamp, Jay T Groves

Sci Adv· June 2024

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Differential Roles of Kinetic On- and Off-Rates in T-Cell Receptor Signal Integration Revealed with a Modified Fab'-DNA Ligand.
Kiera B Wilhelm, Anand Vissa, Jay T Groves

bioRxiv· April 2024

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Allosteric inhibition of the T cell receptor by a designed membrane ligand.
Yujie Ye, Shumpei Morita, Justin J Chang, Patrick M Buckley, Kiera B Wilhelm, Jay T Groves

Elife· October 2023

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Bimodality in Ras signaling originates from processivity of the Ras activator SOS without classic kinetic bistability.
Albert A Lee, Neil H Kim, Steven Alvarez, He Ren, Joseph B DeGrandchamp, Jay T Groves

bioRxiv· July 2023

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A Membrane-Associated Light-Harvesting Model is Enabled by Functionalized Assemblies of Gene-Doubled TMV Proteins.
Jing Dai, Kiera B Wilhelm, Amanda J Bischoff, Jose H Pereira, Michel T Dedeo, Jay T Groves

Small· May 2023

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Stimulation of the catalytic activity of the tyrosine kinase Btk by the adaptor protein Grb2.
Laura M Nocka, Timothy J Eisen, Anthony T Iavarone, Jay T Groves, John Kuriyan

Elife· April 2023

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Discrete LAT condensates encode antigen information from single pMHC:TCR binding events.
Darren B McAffee, Mark K O'Dair, Jenny J Lin, Shalini T Low-Nam, Kiera B Wilhelm, Jay T Groves

Nat Commun· December 2022

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Kinetic frustration by limited bond availability controls the LAT protein condensation phase transition on membranes.
Simou Sun, Trevor GrandPre, David T Limmer, Jay T Groves

Sci Adv· November 2022

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Membrane-mediated dimerization potentiates PIP5K lipid kinase activity.
Scott D Hansen, Albert A Lee, Benjamin R Duewell, Jay T Groves

Elife· August 2022

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Competition for shared downstream signaling molecules establishes indirect negative feedback between EGFR and EphA2.
Dongmyung Oh, Zhongwen Chen, Kabir H Biswas, Funing Bai, Hui Ting Ong, Jay T Groves

Biophys J· May 2022

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A two-component protein condensate of the EGFR cytoplasmic tail and Grb2 regulates Ras activation by SOS at the membrane.
Chun-Wei Lin, Laura M Nocka, Brittany L Stinger, Joseph B DeGrandchamp, L J Nugent Lew, Jay T Groves

Proc Natl Acad Sci U S A· May 2022

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