Publications by authors named "Jayakrishnan Nandakumar"

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Regeneration leads to global tissue rejuvenation in aging sexual planarians.
Xiaoting Dai, Xinghua Li, Alexander Tyshkovskiy, Cassandra Zuckerman, Nan Cheng, Peter Lin, David Paris, Saad Qureshi, Leonid Kruglyak, Xiaoming Mao

Nat Aging· May 2025

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Regenerate to "Rejuvenate": Insights From Adult Resident Stem Cells of Aged Flatworms and Mice.
Kevin A Murach, Cory M Dungan, Toby L Chambers, Steve Horvath, Jayakrishnan Nandakumar

Aging Cell· November 2025

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At the end, it is POT1 again: Phosphorylation allows human telomeric protein POT1 to recruit the C-rich strand end replication machinery.
Katherine Wentworth, Jayakrishnan Nandakumar

Mol Cell· July 2024

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Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB.
Kelly A Manthei, Lia M Munson, Jayakrishnan Nandakumar, Lyle A Simmons

Nucleic Acids Res· June 2024

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telomere-binding proteins TEBP-1 and TEBP-2 adapt the Myb module to dimerize and bind telomeric DNA.
Shilpa Padmanaban, Nils J Lambacher, Valerie M Tesmer, Jingjing Zhang, Hiroki Shibuya, Jayakrishnan Nandakumar

Proc Natl Acad Sci U S A· April 2024

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Structural and biochemical characterization of the mitomycin C repair exonuclease MrfB.
Kelly A Manthei, Lia M Munson, Jayakrishnan Nandakumar, Lyle A Simmons

bioRxiv· February 2024

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Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1.
Lindsay Moritz, Samantha B Schon, Mashiat Rabbani, Yi Sheng, Ritvija Agrawal, Jayakrishnan Nandakumar

Nat Struct Mol Biol· August 2023

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Human POT1 protects the telomeric ds-ss DNA junction by capping the 5' end of the chromosome.
Valerie M Tesmer, Kirsten A Brenner, Jayakrishnan Nandakumar

Science· August 2023

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Interaction hub critical for telomerase recruitment and primer-template handling for catalysis.
Shilpa Padmanaban, Valerie M Tesmer, Jayakrishnan Nandakumar

Life Sci Alliance· June 2023

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Domain specific mutations in dyskerin disrupt 3' end processing of scaRNA13.
Neha Nagpal, Albert K Tai, Jayakrishnan Nandakumar, Suneet Agarwal

Nucleic Acids Res· September 2022

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Consequences of telomere replication failure: the other end-replication problem.
Kirsten A Brenner, Jayakrishnan Nandakumar

Trends Biochem Sci· June 2022

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The KASH5 protein involved in meiotic chromosomal movements is a novel dynein activating adaptor.
Ritvija Agrawal, John P Gillies, Juliana L Zang, Jingjing Zhang, Sharon R Garrott, Jayakrishnan Nandakumar

Elife· June 2022

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Structure and kinase activity of bacterial cell cycle regulator CcrZ.
Katherine J Wozniak, Peter E Burby, Jayakrishnan Nandakumar, Lyle A Simmons

PLoS Genet· May 2022

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BRCA2 in mammalian meiosis.
Jingjing Zhang, Jayakrishnan Nandakumar, Hiroki Shibuya

Trends Cell Biol· April 2022

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Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germline.
Jacqueline V Graniel, Kamlesh Bisht, Ann Friedman, James White, Eric Perkey, Jayakrishnan Nandakumar

Life Sci Alliance· January 2022

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The TERB1 MYB domain suppresses telomere erosion in meiotic prophase I.
Kexin Zhang, Agata Tarczykowska, Deepesh Kumar Gupta, Devon F Pendlebury, Cassandra Zuckerman, Jayakrishnan Nandakumar

Cell Rep· January 2022

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Molecular mechanisms of telomere biology disorders.
Sherilyn Grill, Jayakrishnan Nandakumar

J Biol Chem· September 2021

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The clinical and functional effects of TERT variants in myelodysplastic syndrome.
Christopher R Reilly, Mikko Myllymäki, Robert Redd, Shilpa Padmanaban, Druha Karunakaran, Jayakrishnan Nandakumar

Blood· September 2021

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Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres.
Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M Tesmer, Jayakrishnan Nandakumar

Nat Commun· September 2021

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Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites.
Devon F Pendlebury, Jingjing Zhang, Ritvija Agrawal, Hiroki Shibuya, Jayakrishnan Nandakumar

Nat Struct Mol Biol· August 2021

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TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis.
Sherilyn Grill, Shilpa Padmanaban, Ann Friedman, Eric Perkey, Frederick Allen, Jayakrishnan Nandakumar

JCI Insight· May 2021

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Small Molecules Restore Telomeres in Patient Stem Cells.
Kirsten Ann Brenner, Jayakrishnan Nandakumar

Trends Pharmacol Sci· August 2020

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The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells.
Jingjing Zhang, Manickam Gurusaran, Yasuhiro Fujiwara, Kexin Zhang, Meriem Echbarthi, Jayakrishnan Nandakumar

Nat Commun· April 2020

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Structural biology of telomeres and telomerase.
Eric M Smith, Devon F Pendlebury, Jayakrishnan Nandakumar

Cell Mol Life Sci· January 2020

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Combining conservation and species-specific differences to determine how human telomerase binds telomeres.
Valerie M Tesmer, Eric M Smith, Oana Danciu, Shilpa Padmanaban, Jayakrishnan Nandakumar

Proc Natl Acad Sci U S A· December 2019

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