Nat Aging May 2025 PMID 40181188

Regeneration leads to global tissue rejuvenation in aging sexual planarians.

Xiaoting Dai, Xinghua Li, Alexander Tyshkovskiy, Cassandra Zuckerman, Nan Cheng, Peter Lin, David Paris, Saad Qureshi, Leonid Kruglyak, Xiaoming Mao, Jayakrishnan Nandakumar, Vadim N Gladyshev, Scott Pletcher, Jacob Sobota, Longhua Guo

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Mentions

Peak: 39 in Apr 2025

across 7 sources since Jun 2023

Extended reach

302,523

potential audience

Total likes

208

Video views

4,920

Mentions per month

Jun 2023 – May 2025

Where it's discussed

X / Twitter64 posts
News12 articles
Bluesky4 posts
YouTube2 videos
Facebook2 posts
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AI synopsis

What people are saying

Many discussions highlight key points from the article, with phrases such as 'fascinating phenomenon' and 'could hold the secret to reversing aging' appearing frequently. This choice of enthusiastic language and anticipation reflects the authors' positive stance on the research's potential, emphasizing excitement about the regenerative abilities of planarians.

AgreementStrong agreement

The majority of discussions reflect strong support for the findings detailed in the publication.

InterestHigh interest

Discussions demonstrate a high level of curiosity regarding the implications and applications of the research.

EngagementModerate engagement

While many posts reference the study, most focus on summarizing rather than engaging deeply with the methodologies or implications.

ImpactHigh impact

Participants perceive the research as having significant implications for understanding aging and potential anti-aging strategies.

Abstract in brief

The study reveals that aging in the planarian Schmidtea mediterranea leads to various physiological declines, such as reduced fertility and increased oxidative stress within 18 months of birth.
Single-cell analysis showed significant tissue changes with neuron and muscle loss, along with increased glia, while stem cells remained largely unaffected, indicating specific aging markers.
Interestingly, amputation and regeneration in older planarians reversed many age-related changes, suggesting potential mechanisms for rejuvenation that could inform future anti-aging strategies.

Read the full abstract

All mentions

Regeneration in Planarian Worms: Insights into Aging Reversal

Planarian worms display remarkable regeneration abilities, reversing age-related declines in neurons, muscle mass, and fertility. This video showcases confocal imaging revealing these rejuvenating processes and…

Science X: Phys.org, Medical Xpress, Tech Xplore · Apr 7, 2025 4,895 views

Planarian Worms: Insights into Reversing Human Aging

Scientists discover that aging in planarian worms leads to physiological declines, but regeneration reverses these changes. This study showcases potential rejuvenation mechanisms, indicating that whole-body age reversal…

Science News · Apr 6, 2025 26 views

DreamyDaisy

@DaisyDreamy1231 · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

May 29, 2025 · 8 shares · 31 followers View post →

DreamyDaisy

@DaisyDreamy1231 · X

RT @NatureAging: Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea,…

May 29, 2025 · 6 shares · 31 followers View post →

Yu-ichiro Nakajima

@nyuichiro97 · X

Lab journal club by RK: Regeneration leads to global tissue rejuvenation in aging sexual planarians, Nature Aging https://t.co/ZT4dgeNDyw This work by @longhua_guo describes a fascinating phenomenon, rejuvenation, using sexual planarians from morphological to molecular levels.

May 28, 2025 · 8 likes · 829 followers View post →

Dr. Willie Girald-Rosa

@DrGirald_Rosa · X

https://t.co/KAxnYWs4fx

May 22, 2025 · 135 followers View post →

Jazlyn Mooney, PhD

@Jazlyn_Mooney · X

RT @longhua_guo: Planarians made the cover. Aging and Rejuvenation in planarians: https://t.co/SQXCuHiWnz https://t.co/hj0wdTJGLB

May 21, 2025 · 6 shares · 1,798 followers View post →

Zehao Zhang

@Tommyz626 · X

RT @longhua_guo: Planarians made the cover. Aging and Rejuvenation in planarians: https://t.co/SQXCuHiWnz https://t.co/hj0wdTJGLB

May 21, 2025 · 6 shares · 143 followers View post →

Kevin Murach

@KevinMurachPhD · X

RT @longhua_guo: Planarians made the cover. Aging and Rejuvenation in planarians: https://t.co/SQXCuHiWnz https://t.co/hj0wdTJGLB

May 21, 2025 · 6 shares · 2,975 followers View post →

Bing Ye

@byneuron · X

RT @longhua_guo: Planarians made the cover. Aging and Rejuvenation in planarians: https://t.co/SQXCuHiWnz https://t.co/hj0wdTJGLB

May 21, 2025 · 6 shares · 482 followers View post →

Eudald Pascual

@eudald_pascual · X

RT @longhua_guo: Planarians made the cover. Aging and Rejuvenation in planarians: https://t.co/SQXCuHiWnz https://t.co/hj0wdTJGLB

May 21, 2025 · 6 shares · 906 followers View post →

Yu-ichiro Nakajima

@nyuichiro97 · X

RT @longhua_guo: Planarians made the cover. Aging and Rejuvenation in planarians: https://t.co/SQXCuHiWnz https://t.co/hj0wdTJGLB

May 21, 2025 · 6 shares · 829 followers View post →

Longhua Guo

@longhua_guo · X

Planarians made the cover. Aging and Rejuvenation in planarians: https://t.co/SQXCuHiWnz https://t.co/hj0wdTJGLB

May 21, 2025 · 23 likes · 6 shares · 435 followers View post →

Karen Sullivan

@BiotechLeadKS · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 19, 2025 · 8 shares · 48 followers View post →

Kristian Larsson

@krislongevity · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 19, 2025 · 8 shares · 38 followers View post →

John Greene

@Greene_Thoughts · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 18, 2025 · 8 shares · 1,676 followers View post →

Lucas Schoenfeldt

@schlucas_ · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 18, 2025 · 8 shares · 74 followers View post →

Vanja Tepavcevic

@TepavcevicVanja · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 18, 2025 · 8 shares · 892 followers View post →

Tequehead

@tequehead · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 18, 2025 · 8 shares · 338 followers View post →

José Luis Ricón Fernández de la Puente

@ArtirKel · X

RT @AgingBiology: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 18, 2025 · 8 shares · 21,881 followers View post →

Aging Science News

@AgingBiology · X

Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/ZaSmkTviqN

Apr 18, 2025 · 46 likes · 8 shares · 30,511 followers View post →

BioChemCalc

@BioChemCalc · X

RT @NatureAging: Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea,…

Apr 15, 2025 · 6 shares · 48 followers View post →

Longhua Guo

@longhuaguo.bsky.social · Bluesky

The article: Regeneration leads to global tissue rejuvenation in aging sexual planarians www.nature.com/articles/s43...

Apr 12, 2025 · 1 like · 2 shares View post →

Longhua Guo

@longhua_guo · X

The article: Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/AU1qY8LBUm

Apr 12, 2025 · 1 like · 435 followers View post →

Agingdoc

@agingdoc1 · X

Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/sUBSYClNIp

Apr 11, 2025 · 4 likes · 41,391 followers View post →

八谷一貴D3, Kazuki Hachiya

@Hachiya1224 · X

読んだ。 Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging プラナリアはちぎられた後の再生時に若返る。プラナリアのAdult stem cellsの特徴を模倣して人間の若返りができる未来を作りたい https://t.co/VTkb5OjYG2

Apr 9, 2025 · 1 like · 268 followers View post →

Aging Papers

@PapersAging · X

Regeneration leads to global tissue rejuvenation in aging sexual planarians https://t.co/cmOm9MGbee

Apr 9, 2025 · 16 followers View post →

Mohsin khan Isb

@mohsinAPML1 · X

RT @AusStemCell: ‘This Bizarre “Immortal” Creature Could Hold the Secret to Reversing Aging’ – @UMich team finds planarian worms don’t lose…

Apr 9, 2025 · 2 shares · 1,870 followers View post →

R.A

@raan62 · X

RT @AusStemCell: ‘This Bizarre “Immortal” Creature Could Hold the Secret to Reversing Aging’ – @UMich team finds planarian worms don’t lose…

Apr 9, 2025 · 2 shares · 183 followers View post →

Stem Cell Foundation

@AusStemCell · X

‘This Bizarre “Immortal” Creature Could Hold the Secret to Reversing Aging’ – @UMich team finds planarian worms don’t lose adult stem cells with age and regenerate into youthful versions of themselves, even growing new heads. Paper: https://t.co/MK8hckS4jN https://t.co/qcXx070W9B

Apr 9, 2025 · 4 likes · 2 shares · 14,870 followers View post →

Longhua Guo

@longhua_guo · X

RT @TimePieChina: Planarian worms do not lose adult stem cells with age and can regenerate into a more youthful version of themselves, acco…

Apr 8, 2025 · 1 share · 435 followers View post →

Longhua Guo

@longhua_guo · X

RT @NatureAging: Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea,…

Apr 8, 2025 · 6 shares · 435 followers View post →

Shahriyar Gourgi

@ShahriyarGourgi · X

Planarian worms can regenerate into a more youthful version of themselves https://t.co/0Xcte3AvX3 https://t.co/rQVc0K9I2x https://t.co/osPjnC8gKG

Apr 7, 2025 · 1,991 followers View post →

Lona Mody, MD, M.Sc

@LonaMody · X

RT @NatureAging: Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea,…

Apr 7, 2025 · 6 shares · 786 followers View post →

TimePie (focus on anti-aging science)

@TimePieChina · X

Planarian worms do not lose adult stem cells with age and can regenerate into a more youthful version of themselves, according to a new study by Xiaoting Dai, @longhua_guo @UMich & Vadim N. Gladyshev @gladyshev_lab et al. #aging https://t.co/63Q6S7RUQb https://t.co/Q3pQyExAB0

Apr 7, 2025 · 3 likes · 1 share · 691 followers View post →

Patrick Hu

@patrickhu · X

RT @NatureAging: Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea,…

Apr 7, 2025 · 6 shares · 1,243 followers View post →

Kristian Larsson

@krislongevity · X

RT @NatureAging: Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea,…

Apr 7, 2025 · 6 shares · 38 followers View post →

Nature Aging

@NatureAging · X

Apr 7, 2025 · 15 likes · 6 shares · 18,654 followers View post →

Richard S

@Richard01173388 · X

RT @PlanarianBrain: Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/Hq2wO6jqSz

Apr 5, 2025 · 6 shares · 147 followers View post →

ほしなり

@hosinari · X

RT @PlanarianBrain: Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/Hq2wO6jqSz

Apr 5, 2025 · 6 shares · 261 followers View post →

Mar de Miguel

@MarJungle · X

RT @PlanarianBrain: Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/Hq2wO6jqSz

Apr 5, 2025 · 6 shares · 1,960 followers View post →

Ordo Fraterna Fibonacci

@OrdoFibonacci · X

Regeneration leads to global tissue rejuvenation in aging sexual planarians Nature https://t.co/mvszRN1Oab

Apr 5, 2025 · 2,569 followers View post →

Ordo Fraterna Fibonacci

@ordofibonacci.bsky.social · Bluesky

Regeneration leads to global tissue rejuvenation in aging sexual planarians Nature www.nature.com/articles/s43...

Apr 5, 2025 View post →

Ekasit Sonpho (Program)

@Ekasit_Sp · X

RT @PlanarianBrain: Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/Hq2wO6jqSz

Apr 4, 2025 · 6 shares · 647 followers View post →

Yu-ichiro Nakajima

@nyuichiro97 · X

RT @PlanarianBrain: Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/Hq2wO6jqSz

Apr 4, 2025 · 6 shares · 829 followers View post →

Eudald Pascual

@eudald_pascual · X

RT @PlanarianBrain: Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/Hq2wO6jqSz

Apr 4, 2025 · 6 shares · 906 followers View post →

ぜのぱす（初代_凍結から快復）

@Xenopus007 · X

【memo】 Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/zn4yRENVtP

Apr 4, 2025 · 1 like · 852 followers View post →

INOUE, Takeshi

@planarian-brain.bsky.social · Bluesky

Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging www.nature.com/articles/s43...

Apr 4, 2025 · 6 likes · 2 shares View post →

INOUE, Takeshi

@PlanarianBrain · X

Regeneration leads to global tissue rejuvenation in aging sexual planarians | Nature Aging https://t.co/Hq2wO6jqSz

Apr 4, 2025 · 15 likes · 6 shares · 440 followers View post →

Climate, Ecology, War & More by Dr. Glen Barry, BigEarthData.ai

@bigearthdata.bsky.social · Bluesky

Regeneration leads to global tissue rejuvenation in aging sexual planarians ->Nature | More info from EcoSearch

Apr 3, 2025 View post →

Longhua Guo

@longhua_guo · X