Publications by authors named "Jean Chan"

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ACTM-838, a novel systemically delivered bacterial immunotherapy that enriches in solid tumors and delivers IL-15/IL-15Rα and STING payloads to engage innate and adaptive immunity in the TME and enable a durable anti-tumor immune response.
Kyle R Cron, Ping Fang, Oanh Pham, Julie Janes, John Brandenburg, Jean Chan

Oncotarget· October 2025

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Spencer C Wei, Aaron J Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Jean Chan

PLoS One· June 2025

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Systematic identification and characterization of high efficiency Cas9 guide RNAs for therapeutic targeting of ADAR.
Benjamin G Gowen, Kory Melton, Weng In Leong, Prachi Khekare, Shannon McCawley, Jean Chan

PLoS One· May 2025

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Identification of a Guide RNA Targeting an Ultraconserved Element for Evaluation of Cas9 Genome Editors Across Mammalian Species.
Benjamin G Gowen, Prachi Khekare, Shannon R McCawley, Kory Melton, Craig Soares, Jean Chan

CRISPR J· December 2024

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines.
Spencer C Wei, Aaron J Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Jean Chan

bioRxiv· December 2024

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Phase 3 Trial of Crinecerfont in Pediatric Congenital Adrenal Hyperplasia.
Kyriakie Sarafoglou, Mimi S Kim, Maya Lodish, Eric I Felner, Laetitia Martinerie, Jean L Chan

N Engl J Med· August 2024

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Phase 3 Trial of Crinecerfont in Adult Congenital Adrenal Hyperplasia.
Richard J Auchus, Oksana Hamidi, Rosario Pivonello, Irina Bancos, Gianni Russo, Jean L Chan

N Engl J Med· August 2024

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Crinecerfont, a CRF1 Receptor Antagonist, Lowers Adrenal Androgens in Adolescents With Congenital Adrenal Hyperplasia.
Ron S Newfield, Kyriakie Sarafoglou, Patricia Y Fechner, Natalie J Nokoff, Richard J Auchus, Jean L Chan

J Clin Endocrinol Metab· October 2023

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Noninvasive predictors of clinically significant portal hypertension in NASH cirrhosis: Validation of ANTICIPATE models and development of a lab-based model.
Anahita Rabiee, Yanhong Deng, Maria Ciarleglio, Jean L Chan, Monica Pons

Hepatol Commun· December 2022

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Crinecerfont Lowers Elevated Hormone Markers in Adults With 21-Hydroxylase Deficiency Congenital Adrenal Hyperplasia.
Richard J Auchus, Kyriakie Sarafoglou, Patricia Y Fechner, Maria G Vogiatzi, Erik A Imel, Jean L Chan

J Clin Endocrinol Metab· February 2022

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Multicenter, Double-Blind, Randomized Trial of Emricasan in Hepatitis C-Treated Liver Transplant Recipients With Residual Fibrosis or Cirrhosis.
Ethan M Weinberg, Michael P Curry, Catherine T Frenette, Fredric G Regenstein, Eugene R Schiff, Jean L Chan

Liver Transpl· April 2021

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Emricasan to prevent new decompensation in patients with NASH-related decompensated cirrhosis.
Catherine Frenette, Zeid Kayali, Edward Mena, Parvez S Mantry, Kathryn J Lucas, Jean L Chan

J Hepatol· February 2021

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Attribution of Nonalcoholic Steatohepatitis as an Etiology of Cirrhosis for Clinical Trials Eligibility: Recommendations From the Multi-stakeholder Liver Forum.
Mazen Noureddin, Jean L Chan, Katherine Barradas, Lara Dimick-Santos, Elmer Schabel

Gastroenterology· August 2020

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Randomized placebo-controlled trial of emricasan for non-alcoholic steatohepatitis-related cirrhosis with severe portal hypertension.
Guadalupe Garcia-Tsao, Jaime Bosch, Zeid Kayali, Stephen A Harrison, Manal F Abdelmalek, Jean L Chan

J Hepatol· May 2020

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A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis.
Stephen A Harrison, Zachary Goodman, Abdul Jabbar, Ravi Vemulapalli, Ziad H Younes, Jean L Chan

J Hepatol· May 2020

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Emricasan Improves Liver Function in Patients With Cirrhosis and High Model for End-Stage Liver Disease Scores Compared With Placebo.
Catherine T Frenette, Giuseppe Morelli, Mitchell L Shiffman, R Todd Frederick, Raymond A Rubin, Jean L Chan

Clin Gastroenterol Hepatol· March 2019

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Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension.
Guadalupe Garcia-Tsao, Michael Fuchs, Mitchell Shiffman, Brian B Borg, Nikolaos Pyrsopoulos, Jean L Chan

Hepatology· February 2019

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Randomised clinical trial: emricasan versus placebo significantly decreases ALT and caspase 3/7 activation in subjects with non-alcoholic fatty liver disease.
Mitchell Shiffman, Bradley Freilich, Raj Vuppalanchi, Kymberly Watt, Jean L Chan

Aliment Pharmacol Ther· January 2019

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Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.
Zhenyi Hu, Hiromi Tanji, Shuangshuang Jiang, Shuting Zhang, Kyoin Koo, Jean Chan

Cell Chem Biol· October 2018

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Lymphoma in acquired generalized lipodystrophy.
Rebecca J Brown, Jean L Chan, Elaine S Jaffe, Elaine Cochran, Alex M DePaoli

Leuk Lymphoma· October 2016

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Immunogenicity associated with metreleptin treatment in patients with obesity or lipodystrophy.
Jean L Chan, Joy Koda, Joseph S Heilig, Elaine K Cochran, Phillip Gorden

Clin Endocrinol (Oxf)· July 2016

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The clinical approach to the detection of lipodystrophy - an AACE consensus statement.
Yehuda Handelsman, Elif A Oral, Zachary T Bloomgarden, Rebecca J Brown, Jean L Chan

Endocr Pract· August 2013

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Cricoid pressure provides incomplete esophageal occlusion associated with lateral deviation: a magnetic resonance imaging study.
Sylvain Boet, Kaylene Duttchen, Jean Chan, An-Wen Chan, William Morrish

J Emerg Med· May 2012

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Clinical effects of long-term metreleptin treatment in patients with lipodystrophy.
Jean L Chan, Karen Lutz, Elaine Cochran, Wenying Huang, Yvette Peters

Endocr Pract· May 2012

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TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus.
Cristiana Guiducci, Mei Gong, Zhaohui Xu, Michelle Gill, Damien Chaussabel, Jean H Chan

Nature· June 2010

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