Publications by authors named "Jean Dinh"

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Investigating Sulfotransferase Mediated Drug Interactions of Ethinylestradiol using a Physiologically Based Pharmacokinetic Model.
Harry P Moore, Kuan-Fu Chen, Aki T Heikkinen, Sibylle Neuhoff, Udoamaka Ezuruike, Jean Dinh

AAPS J· November 2025

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Development, Verification, and Application of a Chinese Pediatric Physiologically Based Pharmacokinetic Model: Emphasis on CYP Metabolism and Renal Elimination.
Rosalind L Southall, Jean Dinh, Xian Pan, Jia Ning, Trevor N Johnson

AAPS J· November 2025

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Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations.
Udoamaka Ezuruike, Jean Dinh, Eman El-Khateeb, Alex Blenkinsop, Oliver Hatley

CPT Pharmacometrics Syst Pharmacol· October 2025

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Postpartum changes in maternal physiology and milk composition: a comprehensive database for developing lactation physiologically-based pharmacokinetic models.
Neel Deferm, Jean Dinh, Amita Pansari, Masoud Jamei, Khaled Abduljalil

Front Pharmacol· February 2025

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Physiologically Based Pharmacokinetic Modeling of Cannabidiol, Delta-9-Tetrahydrocannabinol, and Their Metabolites in Healthy Adults After Administration by Multiple Routes.
Lixuan Qian, Tao Zhang, Jean Dinh, Mary F Paine, Zhu Zhou

Clin Transl Sci· January 2025

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Prediction of Pediatric Pharmacokinetics for CYP3A4 Metabolized Drugs: Comparison of the Performance of Two Hepatic Ontogeny Within a Physiologically Based Pharmacokinetic Model.
Marc Codaccioni, Rosalind L Southall, Jean Dinh, Trevor N Johnson

J Clin Pharmacol· September 2024

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Combining data on the bioavailability of midazolam and physiologically-based pharmacokinetic modeling to investigate intestinal CYP3A4 ontogeny.
Trevor N Johnson, Hannah K Batchelor, Jan Goelen, Richard D Horniblow, Jean Dinh

CPT Pharmacometrics Syst Pharmacol· September 2024

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Impact of CYP2C:TG Haplotype on CYP2C19 Substrates Clearance In Vivo, Protein Content, and In Vitro Activity.
Pablo Zubiaur, Paula Soria-Chacartegui, Erin C Boone, Bhagwat Prasad, Jean Dinh

Clin Pharmacol Ther· November 2023

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Physiologically Based Pharmacokinetics Modeling in the Neonatal Population-Current Advances, Challenges, and Opportunities.
Jean Dinh, Trevor N Johnson, Manuela Grimstein, Tamorah Lewis

Pharmaceutics· November 2023

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Selective deuteration of bupropion slows epimerization and reduces metabolism.
Yuanyuan Shi, Jean Dinh, Robert Pelletier, Brianne Raccor, Naeem Yusuff

Bioorg Med Chem Lett· November 2022

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Cardiac Disease Alters Myocardial Tissue Levels of Epoxyeicosatrienoic Acids and Key Proteins Involved in Their Biosynthesis and Degradation.
Theresa Aliwarga, Jean C Dinh, Scott Heyward, Bhagwat Prasad, Sina A Gharib

Int J Mol Sci· October 2022

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The Impact of the CYP2D6 "Enhancer" Single Nucleotide Polymorphism on CYP2D6 Activity.
Jean C Dinh, Erin C Boone, Vincent S Staggs, Robin E Pearce, Wendy Y Wang

Clin Pharmacol Ther· March 2022

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Ontogeny of Scaling Factors for Pediatric Physiology-Based Pharmacokinetic Modeling and Simulation: Microsomal Protein Per Gram of Liver.
J Steven Leeder, Jean C Dinh, Andrea Gaedigk, Vincent S Staggs, Bhagwat Prasad

Drug Metab Dispos· January 2022

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Is this the end for ranitidine? NDMA presence continues to confound.
Jennifer A Wagner, Jean C Dinh, Jennifer R Lightdale, Benjamin D Gold, Jennifer M Colombo

Clin Transl Sci· July 2021

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The Respective Roles of CYP3A4 and CYP2D6 in the Metabolism of Pimozide to Established and Novel Metabolites.
Brian D Chapron, Jean C Dinh, Paul C Toren, Andrea Gaedigk, J Steven Leeder

Drug Metab Dispos· November 2020

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Pediatric Clinical Endpoint and Pharmacodynamic Biomarkers: Limitations and Opportunities.
Jean C Dinh, Chelsea M Hosey-Cojocari, Bridgette L Jones

Paediatr Drugs· February 2020

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Clinical Pharmacogenetics Implementation Consortium Guideline for Cytochrome P450 (CYP)2D6 Genotype and Atomoxetine Therapy.
Jacob T Brown, Jeffrey R Bishop, Katrin Sangkuhl, Erika L Nurmi, Daniel J Mueller, Jean C Dinh

Clin Pharmacol Ther· July 2019

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Description of an Innovative Pediatric Individualized Therapeutics Clinic: Working toward Precision Drug Therapy.
Tracy L Sandritter, Jean C Dinh, Jennifer A Wagner, Jennifer A Lowry

Children (Basel)· February 2019

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Ten Years' Experience with the CYP2D6 Activity Score: A Perspective on Future Investigations to Improve Clinical Predictions for Precision Therapeutics.
Andrea Gaedigk, Jean C Dinh, Hyunyoung Jeong, Bhagwat Prasad, J Steven Leeder

J Pers Med· April 2018

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Characterization of Atomoxetine Biotransformation and Implications for Development of PBPK Models for Dose Individualization in Children.
Jean C Dinh, Robin E Pearce, Leon Van Haandel, Andrea Gaedigk, J Steven Leeder

Drug Metab Dispos· July 2016

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Potential contribution of cytochrome P450 2B6 to hepatic 4-hydroxycyclophosphamide formation in vitro and in vivo.
Brianne S Raccor, Adam J Claessens, Jean C Dinh, Julie R Park, Douglas S Hawkins

Drug Metab Dispos· January 2012

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