Publications by authors named "Jean Zhao"

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PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive Tumorigenesis.
Shuang Tang, Qian Zhou, Johann S Bergholz, Tao Jiang, Weihua Wang, Jean J Zhao

Cancer Discov· November 2025

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Beyond G protein and arrestin: GRK2-biased β₂AR signaling.
Ren-Lei Ji, Zhe Wang, Jean J Zhao

Trends Pharmacol Sci· October 2025

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IRG1/itaconate/NRF2/GSH axis in tumor-associated macrophages drives therapy resistance and immune evasion in BRCA1-deficient breast cancer.
Yabing Nan, Sophie O'keefe, Xiadi He, Qingyu Luo, Xiaowei Wu, Jean J Zhao

bioRxiv· October 2025

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Loss of the tumor suppressor PTEN activates cell-intrinsic interferon signaling to drive immune resistance.
Yubao Wang, Cherubin Manokaran, Jiajia Chen, Hao Gu, David Liu, Jean J Zhao

bioRxiv· September 2025

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Dual Modes of Gene Regulation by CDK12.
Yubao Wang, Apoorva Baluapuri, Cherubin Manokaran, Jing Ni, Tao Jiang, Jean Zhao

bioRxiv· September 2025

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Genomic landscape and immunological profile of glioblastoma in East Asian patients.
Sheng Zhong, Bo Wu, Frank Dubois, Davy Deng, Johann S Bergholz, Zheng Zhao, Jean J Zhao

Cell Rep Med· August 2025

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Radiation-guided nanoparticles enhance the efficacy of PARP inhibitors in primary and metastatic BRCA1-deficient tumors via immunotherapy.
Rami Khoury, Giuseppe Longobardi, Tania T Barnatan, Dana Venkert, América García Alvarado, Jean J Zhao

J Control Release· July 2025

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Statin-dye conjugates for selective targeting of mutant cancer cells.
Hye-Ran Moon, Zhenying Cai, Bo Kyung Cho, Hyeyoun Chang, Seung Taek Hong, Jean J Zhao

bioRxiv· June 2025

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Editorial Expression of Concern: Essential roles of PI(3)K-p110β in cell growth, metabolism and tumorigenesis.
Shidong Jia, Zhenning Liu, Sen Zhang, Pixu Liu, Lei Zhang, Jean J Zhao

Nature· May 2025

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Lysine vitcylation is a vitamin C-derived protein modification that enhances STAT1-mediated immune response.
Xiadi He, Qiwei Wang, Xin Cheng, Weihua Wang, Yutong Li, Jean J Zhao

Cell· April 2025

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Breakage fusion bridge cycles drive high oncogene number with moderate intratumoural heterogeneity.
Siavash Raeisi Dehkordi, Ivy Tsz-Lo Wong, Jing Ni, Jens Luebeck, Kaiyuan Zhu, Jean Zhao

Nat Commun· February 2025

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PI(3,5)P Controls the Signaling Activity of Class I PI3K.
Jiachen Sun, Julian Zalejski, Seohyeon Song, Ashutosh Sharma, Wei Wang, Jean J Zhao

bioRxiv· January 2025

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Editor's Note: Androgen-Induced Differentiation and Tumorigenicity of Human Prostate Epithelial Cells.
Raanan Berger, Phillip G Febbo, Pradip K Majumder, Jean J Zhao, Shayan Mukherjee

Cancer Res· August 2024

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Correction: Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers.
Bowen Sun, Seth Mason, Robert C Wilson, Starr E Hazard, Yubao Wang, Jean J Zhao

Oncogene· June 2024

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PI3Kγ maintains the self-renewal of acute myeloid leukemia stem cells by regulating the pentose phosphate pathway.
Hao Gu, Chiqi Chen, Zhi-Shuai Hou, Xia-Di He, Shaozhen Xie, Jean J Zhao

Blood· May 2024

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Selective CDK7 Inhibition Suppresses Cell Cycle Progression and MYC Signaling While Enhancing Apoptosis in Therapy-resistant Estrogen Receptor-positive Breast Cancer.
Cristina Guarducci, Agostina Nardone, Douglas Russo, Zsuzsanna Nagy, Capucine Heraud, Jean J Zhao

Clin Cancer Res· May 2024

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Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change.
Siavash Raeisi Dehkordi, Ivy Tsz-Lo Wong, Jing Ni, Jens Luebeck, Kaiyuan Zhu, Jean Zhao

bioRxiv· December 2023

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Lysine vitcylation is a novel vitamin C-derived protein modification that enhances STAT1-mediated immune response.
Xiadi He, Yun Wei, Jiang Wu, Qiwei Wang, Johann S Bergholz, Jean J Zhao

bioRxiv· June 2023

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PI3Kβ controls immune evasion in PTEN-deficient breast tumours.
Johann S Bergholz, Qiwei Wang, Qi Wang, Michelle Ramseier, Sanjay Prakadan, Jean J Zhao

Nature· May 2023

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Lactate regulates cell cycle by remodelling the anaphase promoting complex.
Weihai Liu, Yun Wang, Luiz H M Bozi, Patrick D Fischer, Mark P Jedrychowski, Jean J Zhao

Nature· April 2023

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Targeting tumor-associated macrophages with STING agonism improves the antitumor efficacy of osimertinib in a mouse model of mutant lung cancer.
Ziying Lin, Qiwei Wang, Tao Jiang, Weihua Wang, Jean J Zhao

Front Immunol· March 2023

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Preclinical and Clinical Efficacy of Trastuzumab Deruxtecan in Breast Cancer Brain Metastases.
Sheheryar Kabraji, Jing Ni, Sarah Sammons, Tianyu Li, Amanda E D Van Swearingen, Jean J Zhao

Clin Cancer Res· January 2023

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STING agonism overcomes STAT3-mediated immunosuppression and adaptive resistance to PARP inhibition in ovarian cancer.
Liya Ding, Qiwei Wang, Antons Martincuks, Michael J Kearns, Tao Jiang, Jean J Zhao

J Immunother Cancer· January 2023

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Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides.
Dali Wang, Qiwei Wang, Yuyan Wang, Peiru Chen, Xueguang Lu, Jean J Zhao

Proc Natl Acad Sci U S A· July 2022

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STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer.
Qiwei Wang, Johann S Bergholz, Liya Ding, Ziying Lin, Sheheryar K Kabraji, Jean J Zhao

Nat Commun· May 2022

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