Publications by authors named "Jean-Christophe Simard"

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Fatty acid mimetic PBI-4547 restores metabolic homeostasis via GPR84 in mice with non-alcoholic fatty liver disease.
Jean-Christophe Simard, Jean-François Thibodeau, Martin Leduc, Mikael Tremblay, Alexandre Laverdure

Sci Rep· July 2020

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PBI-4050 via GPR40 activation improves adenine-induced kidney injury in mice.
Jean-François Thibodeau, Jean-Christophe Simard, Chet E Holterman, Amélie Blais, Marie-Pier Cloutier

Clin Sci (Lond)· July 2019

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PBI-4050 Reduces Stellate Cell Activation and Liver Fibrosis through Modulation of Intracellular ATP Levels and the Liver Kinase B1/AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway.
Brigitte Grouix, Francois Sarra-Bournet, Martin Leduc, Jean-Christophe Simard, Kathy Hince

J Pharmacol Exp Ther· October 2018

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A Newly Discovered Antifibrotic Pathway Regulated by Two Fatty Acid Receptors: GPR40 and GPR84.
Lyne Gagnon, Martin Leduc, Jean-Francois Thibodeau, Ming-Zhi Zhang, Brigitte Grouix, Jean-Christophe Simard

Am J Pathol· May 2018

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Quinoline-3-carboxamides such as tasquinimod are not specific inhibitors of S100A9.
Martin Pelletier, Jean-Christophe Simard, Denis Girard, Philippe A Tessier

Blood Adv· May 2018

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Activation of human AML14.3D10 eosinophils by nanoparticles: Modulatory activity on apoptosis and cytokine production.
Francis Vallières, Jean-Christophe Simard, Claudie Noël, Maxime Murphy-Marion, Valerie Lavastre

J Immunotoxicol· November 2016

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Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells.
Jean-Christophe Simard, Isabelle Durocher, Denis Girard

Apoptosis· November 2016

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Silver nanoparticles of 70 nm and 20 nm affect differently the biology of human neutrophils.
Michelle Poirier, Jean-Christophe Simard, Denis Girard

J Immunotoxicol· May 2016

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Gold nanoparticles induce apoptosis, endoplasmic reticulum stress events and cleavage of cytoskeletal proteins in human neutrophils.
Claudie Noël, Jean-Christophe Simard, Denis Girard

Toxicol In Vitro· March 2016

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Prolonged cultures of unstimulated human neutrophils lead to the apparition and persistence of rest-in-plate structures (RIPs) recognized by professional phagocytes in vitro and in vivo.
Francis Vallières, Jean-Christophe Simard, Théo Stafford-Richard, Denis Girard

Int J Biochem Cell Biol· December 2015

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Silver nanoparticles rapidly induce atypical human neutrophil cell death by a process involving inflammatory caspases and reactive oxygen species and induce neutrophil extracellular traps release upon cell adhesion.
Rafael Liz, Jean-Christophe Simard, Laurien Bruna Araújo Leonardi, Denis Girard

Int Immunopharmacol· September 2015

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Silver nanoparticles induce degradation of the endoplasmic reticulum stress sensor activating transcription factor-6 leading to activation of the NLRP-3 inflammasome.
Jean-Christophe Simard, Francis Vallieres, Rafael de Liz, Valerie Lavastre, Denis Girard

J Biol Chem· February 2015

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Human S100A9 potentiates IL-8 production in response to GM-CSF or fMLP via activation of a different set of transcription factors in neutrophils.
Jean-Christophe Simard, Claudie Noël, Philippe A Tessier, Denis Girard

FEBS Lett· June 2014

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S100A8 and S100A9 induce cytokine expression and regulate the NLRP3 inflammasome via ROS-dependent activation of NF-κB(1.).
Jean-Christophe Simard, Annabelle Cesaro, Julie Chapeton-Montes, Mélanie Tardif, Francis Antoine

PLoS One· April 2014

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Interaction between silver nanoparticles of 20 nm (AgNP20 ) and human neutrophils: induction of apoptosis and inhibition of de novo protein synthesis by AgNP20 aggregates.
Michelle Poirier, Jean-Christophe Simard, Francis Antoine, Denis Girard

J Appl Toxicol· April 2014

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Curcumin inhibits agent-induced human neutrophil functions in vitro and lipopolysaccharide-induced neutrophilic infiltration in vivo.
Francis Antoine, Jean-Christophe Simard, Denis Girard

Int Immunopharmacol· December 2013

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Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis.
Jean-Christophe Simard, Marie-Michelle Simon, Philippe A Tessier, Denis Girard

J Immunol· March 2011

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Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism.
Jean-Christophe Simard, Denis Girard, Philippe A Tessier

J Leukoc Biol· May 2010

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