Publications by authors named "Jeegar Patel"

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Pharmacological profile and therapeutic evaluation of ROC-101, a potent and selective ROCK inhibitor, in arterial hypertension and pulmonary fibrosis.
Rigen Mo, Sarah Lucas, Xiao-Jiang Feng, Adrian Hackett, Ed Skucas, Jeegar P Patel

Pharmacol Res· December 2025

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In Vitro and Clinical Evaluations of UGT1A1-, P-gp-, OATP1B1-, and BCRP-Mediated Drug-Drug Interactions of Belumosudil, a Potent ROCK2 Inhibitor.
Olivier Schueller, Lauren Lohmer, Felix Beck, Jeegar Patel, Jasminder Sahi

J Clin Pharmacol· August 2025

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Pharmacokinetics of Belumosudil and Its Metabolites in Individuals With Hepatic Impairment.
Olivier Schueller, Virginie Esposito, Lauren Lohmer, Felix Beck, Lenore Teichert, Jeegar Patel

Clin Transl Sci· July 2025

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Two-Part Phase 1 Study to Evaluate the Taste Profile of Novel Belumosudil Oral Suspensions and Assess the Relative Bioavailability and Food Effect of the Selected Belumosudil Oral Suspension Compared With Oral Tablet Reference in Healthy Male Participants.
Olivier Schueller, Galit Regev, Nand Singh, Ashley Willson, Mark Beville, Jeegar Patel

Clin Pharmacol Drug Dev· May 2024

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Radiological Evaluation of OrthAlign-A Novel Handheld Navigation System used in Total Knee Replacement.
Jeegar M Patel, Krishan Yadav, Rohit G Daga, Mohan Sadaria

J Pharm Bioallied Sci· July 2023

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Evaluation of the clinical molecule anti-human-PD-L1/IL-15 KD033 in the human-PD-1/PD-L1-expressing murine model demonstrates PD-L1 targeting of IL-15 in vivo.
Stella A Martomo, Jeegar Patel

Cancer Immunol Immunother· June 2023

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A Phase 1 Thorough QT/QTc Study of Therapeutic and Supratherapeutic Doses of Belumosudil in Healthy Subjects.
Olivier Schueller, Lauren Lohmer, Hongqi Xue, Borje Darpo, Jeegar Patel

Clin Pharmacol Drug Dev· October 2022

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A Phase 1 Pharmacokinetic Drug Interaction Study of Belumosudil Coadministered With CYP3A4 Inhibitors and Inducers and Proton Pump Inhibitors.
Olivier Schueller, Ashley Willson, Nand Singh, Lauren Lohmer, Anginelle Alabanza, Jeegar Patel

Clin Pharmacol Drug Dev· July 2022

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Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [ C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study.
Olivier Schueller, Ed Skucas, Galit Regev, Iain Shaw, Nand Singh, Jeegar Patel

Clin Pharmacol Drug Dev· July 2022

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Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects.
Olivier Schueller, John McDermott, Phil Evans, Lauren Lohmer, Anginelle Alabanza, Jeegar Patel

Clin Pharmacol Drug Dev· July 2022

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Functional antibody characterization via direct structural analysis and information-driven protein-protein docking.
Rafael S Depetris, Dan Lu, Zhanna Polonskaya, Zhikai Zhang, Xenia Luna, Jeegar P Patel

Proteins· April 2022

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Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors.
Kellen Olszewski, Anthony Barsotti, Xiao-Jiang Feng, Milica Momcilovic, Kevin G Liu, Jeegar P Patel

Cell Chem Biol· March 2022

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ROCK2 Inhibition With Belumosudil (KD025) for the Treatment of Chronic Graft-Versus-Host Disease.
Madan Jagasia, Aleksandr Lazaryan, Carlos R Bachier, Amandeep Salhotra, Daniel J Weisdorf, Jeegar Patel

J Clin Oncol· June 2021

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Single-Dose Anti-PD-L1/IL-15 Fusion Protein KD033 Generates Synergistic Antitumor Immunity with Robust Tumor-Immune Gene Signatures and Memory Responses.
Stella A Martomo, Dan Lu, Zhanna Polonskaya, Xenia Luna, Zhikai Zhang, Jeegar Patel

Mol Cancer Ther· February 2021

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Discovery and Optimization of Glucose Uptake Inhibitors.
Kevin G Liu, Ji-In Kim, Kellen Olszewski, Anthony M Barsotti, Koi Morris, Jeegar P Patel

J Med Chem· May 2020

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Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO.
Jeegar P Patel, Rajarshi Sengupta, Giuseppe Bardi, Muhammad Z Khan, Anna Mullen-Przeworski

J Neurovirol· December 2006

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Human immunodeficiency virus gp120-induced apoptosis of human neuroblastoma cells in the absence of CXCR4 internalization.
Giuseppe Bardi, Rajarshi Sengupta, Muhammad Z Khan, Jeegar P Patel, Olimpia Meucci

J Neurovirol· June 2006

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Regulation of neuronal P53 activity by CXCR 4.
Muhammad Z Khan, Saori Shimizu, Jeegar P Patel, Autumn Nelson, My-Thao Le

Mol Cell Neurosci· September 2005

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Apoptotic and antiapoptotic effects of CXCR4: is it a matter of intrinsic efficacy? Implications for HIV neuropathogenesis.
Muhammad Z Khan, Renato Brandimarti, Jeegar P Patel, Nha Huynh, Jun Wang

AIDS Res Hum Retroviruses· October 2004

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