Publications by authors named "Jeff Lutman"

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Utilizing PK and PD Biomarkers to Guide the First-in-Human Starting Dose Selection of MTBT1466A: A Novel Humanized Monoclonal Anti-TGFβ3 Antibody for the Treatment of Fibrotic Diseases.
Rajbharan Yadav, Siddharth Sukumaran, Jeff Lutman, Mayur S Mitra, Wendy Halpern

J Pharm Sci· November 2023

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Challenges with development of a pharmacokinetics assay to measure a variably glycosylated fusion protein.
Gizette Sperinde, Luna Liu, Keyang Xu, Tracy Bentley, Sid Sukumaran, Jeff Lutman

Bioanalysis· January 2022

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TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis.
Tianhe Sun, Zhiyu Huang, Wei-Ching Liang, Jianping Yin, Wei Yu Lin, Jeff Lutman

Sci Transl Med· August 2021

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Assessment of low volume sampling technologies: utility in nonclinical and clinical studies.
Kathi J Williams, Jeff Lutman, Cynthia McCaughey, Saloumeh K Fischer

Bioanalysis· May 2021

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Henry R Maun, Janet K Jackman, David F Choy, Kelly M Loyet, Tracy L Staton, Jeff Lutman

Cell· January 2020

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An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Henry R Maun, Janet K Jackman, David F Choy, Kelly M Loyet, Tracy L Staton, Jeff Lutman

Cell· October 2019

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Nonclinical safety assessment of a human interleukin-22FC IG fusion protein demonstrates in vitro to in vivo and cross-species translatability.
Donna W Lee, Shelly Zhong, Rama Pai, Julie Rae, Siddharth Sukumaran, Jeff Lutman

Pharmacol Res Perspect· December 2018

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Pre-clinical and translational pharmacology of a human interleukin-22 IgG fusion protein for potential treatment of infectious or inflammatory diseases.
Eric G Stefanich, Julie Rae, Siddharth Sukumaran, Jeff Lutman, Annemarie Lekkerkerker

Biochem Pharmacol· June 2018

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Preclinical pharmacokinetics of MHAA4549A, a human monoclonal antibody to influenza A virus, and the prediction of its efficacious clinical dose for the treatment of patients hospitalized with influenza A.
Priyanka Gupta, Amrita V Kamath, Summer Park, Henry Chiu, Jeff Lutman

MAbs· July 2016

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A novel immunoassay to measure total serum lymphotoxin-α levels in the presence of an anti-LTα therapeutic antibody.
Judy Young, Allen Nguyen, Zhihua Julia Qiu, Yong Ying, Xiaoying Gao, Jeff Lutman

J Immunol Methods· September 2015

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Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.
Steven E Kauder, Lydia Santell, Elaine Mai, Lilyan Y Wright, Elizabeth Luis, Jeff Lutman

PLoS One· August 2014

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A strategy for risk mitigation of antibodies with fast clearance.
Isidro Hötzel, Frank-Peter Theil, Lisa J Bernstein, Saileta Prabhu, Rong Deng, Jeff Lutman

MAbs· January 2014

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Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans.
Marcella Yu, Darren Brown, Chae Reed, Shan Chung, Jeff Lutman

MAbs· November 2012

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Subcutaneous bioavailability of therapeutic antibodies as a function of FcRn binding affinity in mice.
Rong Deng, Y Gloria Meng, Kwame Hoyte, Jeff Lutman, Yanmei Lu

MAbs· June 2012

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Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis.
Chia-Lin Hsu, Weiyu Lin, Dhaya Seshasayee, Yung-Hsiang Chen, Xiao Ding, Jeff L Lutman

Science· January 2012

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