Publications by authors named "Jeffery D Molkentin"

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D
DWORF Gene Therapy Improves Cardiac Calcium Handling and Mitochondrial Function.
Omar Brito-Estrada, Yasuhide Kuwabara, Aaron M Gibson, Keira R Hassel, Michael L Kamradt, Jeffery D Molkentin

Circ Res· September 2025

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Cardiomyocyte-expressed TGFβ signals to fibroblasts to program early heart maturation and adult myocyte identity.
Rachel A Minerath, Rajesh K Kasam, Casey O Swoboda, Vikram Prasad, Kelly M Grimes, Jeffery D Molkentin

bioRxiv· September 2025

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Hepato-cardiac interorgan communication controls cardiac hypertrophy via combined endocrine-autocrine FGF21 signaling.
Sobuj Mia, Georgios Siokatas, Rafailia Sidiropoulou, Matthew Hoffman, Konstantinos Fragkiadakis, Jeffery D Molkentin

Cell Rep Med· June 2025

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Atad3 is Essential for Mitochondrial Permeability Transition Pore Opening and Cardiac Ischemia Reperfusion Injury.
Dexter Robichaux, Sual J Lopez, Arielys Mendoza, Daniel Ramirez, Suh-Chin J Lin, Jeffery D Molkentin

bioRxiv· June 2025

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Transcription Factor 21 Regulates Cardiac Myofibroblast Formation and Fibrosis.
Anne Katrine Z Johansen, Rajesh K Kasam, Ronald J Vagnozzi, Suh-Chin J Lin, Jose Gomez-Arroyo, Jeffery D Molkentin

Circ Res· January 2025

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MICU1 and MICU2, two peas in a pod or entirely different fruits?
Jiuzhou Huo, Jeffery D Molkentin

Cell Calcium· December 2024

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The adenine nucleotide translocase family underlies cardiac ischemia-reperfusion injury through the mitochondrial permeability pore independently of cyclophilin D.
Pooja Patel, Arielys Mendoza, Daniel Ramirez, Dexter Robichaux, Jeffery D Molkentin

Sci Adv· December 2024

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MCU genetically altered mice suggest how mitochondrial Ca regulates metabolism.
Jiuzhou Huo, Jeffery D Molkentin

Trends Endocrinol Metab· October 2024

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EMC3 regulates trafficking and pulmonary toxicity of the SFTPCI73T mutation associated with interstitial lung disease.
Xiaofang Tang, Wei Wei, Yuqing Sun, Timothy E Weaver, Ernesto S Nakayasu, Jeffery D Molkentin

J Clin Invest· October 2024

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Genetic and Pharmacologic Inhibition of JAK1/2 Antagonizes Cardiac Fibrosis.
Qinghang Meng, Bo Yang, Yan Qiao, Yingxin Wu, Jie Chen, Jeffery D Molkentin

Circulation· September 2024

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Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner.
Davy Vanhoutte, Tobias G Schips, Rachel A Minerath, Jiuzhou Huo, Naga Swathi Sree Kavuri, Jeffery D Molkentin

Cell Rep· May 2024

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MCU-independent Ca uptake mediates mitochondrial Ca overload and necrotic cell death in a mouse model of Duchenne muscular dystrophy.
Michael J Bround, Eaman Abay, Jiuzhou Huo, Julian R Havens, Allen J York, Jeffery D Molkentin

Sci Rep· March 2024

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MEK1-ERK1/2 signaling regulates the cardiomyocyte non-sarcomeric actin cytoskeletal network.
Kelly M Grimes, Marjorie Maillet, Casey O Swoboda, Stephanie L K Bowers, Doug P Millay, Jeffery D Molkentin

Am J Physiol Heart Circ Physiol· January 2024

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Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy.
Tanya A Baldwin, James P Teuber, Yasuhide Kuwabara, Araskumar Subramani, Suh-Chin J Lin, Jeffery D Molkentin

J Biol Chem· December 2023

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MCUb is an inducible regulator of calcium-dependent mitochondrial metabolism and substrate utilization in muscle.
Jiuzhou Huo, Vikram Prasad, Kelly M Grimes, Davy Vanhoutte, N Scott Blair, Jeffery D Molkentin

Cell Rep· November 2023

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ANT-dependent MPTP underlies necrotic myofiber death in muscular dystrophy.
Michael J Bround, Julian R Havens, Allen J York, Michelle A Sargent, Jason Karch, Jeffery D Molkentin

Sci Adv· August 2023

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-Deleted Mice Have Defective Type I Collagen and Secondary Reactive Cardiac Fibrosis with Altered Hypertrophic Dynamics.
Stephanie L K Bowers, Qinghang Meng, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Jeffery D Molkentin

Cells· August 2023

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A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy.
Yasuhide Kuwabara, Allen J York, Suh-Chin Lin, Michelle A Sargent, Kelly M Grimes, Jeffery D Molkentin

Proc Natl Acad Sci U S A· May 2023

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Interleukin-33 Mediates Cardiomyopathy After Acute Kidney Injury by Signaling to Cardiomyocytes.
Nans Florens, Rajesh K Kasam, Valeria Rudman-Melnick, Suh-Chin Lin, Vikram Prasad, Jeffery D Molkentin

Circulation· February 2023

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An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
Ruorong Yan, Valentina Cigliola, Kelsey A Oonk, Zachary Petrover, Sophia DeLuca, Jeffery D Molkentin

Cell Stem Cell· January 2023

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gene deletion in mice reduces heart weight over time.
Kelly M Grimes, Vikram Prasad, Jiuzhou Huo, Yasuhide Kuwabara, Davy Vanhoutte, Jeffery D Molkentin

Front Physiol· January 2023

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Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy.
Michelle Wintzinger, Karen Miz, Allen York, Alexis R Demonbreun, Jeffery D Molkentin

Methods Mol Biol· November 2022

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Loss of Acta2 in cardiac fibroblasts does not prevent the myofibroblast differentiation or affect the cardiac repair after myocardial infarction.
Yuxia Li, Chaoyang Li, Qianglin Liu, Leshan Wang, Adam X Bao, Jeffery D Molkentin

J Mol Cell Cardiol· October 2022

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Remembering Jeff Robbins: The Father of Cardiac Transgenesis.
Jeffery D Molkentin, Leslie A Leinwand

JACC Basic Transl Sci· October 2022

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Ca channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons.
Enrico Zampese, David L Wokosin, Patricia Gonzalez-Rodriguez, Jaime N Guzman, Tatiana Tkatch, Jeffery D Molkentin

Sci Adv· September 2022

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