Publications by authors named "Jeffrey A Toretsky"

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A Novel FLI1 Monoclonal Antibody Which Recognizes EWS::FLI1 with High Affinity Is Useful for Detecting Ewing Sarcoma.
Saravana P Selvanathan, Olivia O Lansinger, David V Allegakoen, Emma J W McGuire, Ashley R Gaffey, Jeffrey A Toretsky

Antibodies (Basel)· November 2025

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Open-Label, Multicenter, Phase I/II, First-in-Human Trial of TK216: A First-Generation EWS::FLI1 Fusion Protein Antagonist in Ewing Sarcoma.
Paul A Meyers, Noah Federman, Najat Daw, Peter M Anderson, Lara E Davis, Jeffrey A Toretsky

J Clin Oncol· November 2024

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Retraction: Combining PARP-1 Inhibition and Radiation in Ewing Sarcoma Results in Lethal DNA Damage.
Hae-June Lee, Changhwan Yoon, Benjamin Schmidt, Do Joong Park, Alexia Y Zhang, Jeffrey A Toretsky

Mol Cancer Ther· November 2024

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Piperacetazine Directly Binds to the PAX3::FOXO1 Fusion Protein and Inhibits Its Transcriptional Activity.
Kay Nakazawa, Taryn Shaw, Young K Song, Marilyn Kouassi-Brou, Anna Molotkova, Jeffrey A Toretsky

Cancer Res Commun· October 2023

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Widespread hypertranscription in aggressive human cancers.
Matthew Zatzman, Fabio Fuligni, Ryan Ripsman, Tannu Suwal, Federico Comitani, Jeffrey A Toretsky

Sci Adv· November 2022

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An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma.
David S Shulman, Sarah B Whittle, Didier Surdez, Kelly M Bailey, Enrique de Álava, Jeffrey A Toretsky

NPJ Precis Oncol· September 2022

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Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations.
Na Sun, Benjamin V Tran, Zishan Peng, Jing Wang, Ceng Zhang, Jeffrey A Toretsky

Adv Sci (Weinh)· May 2022

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Comprehensive profiling of mRNA splicing indicates that GC content signals altered cassette exon inclusion in Ewing sarcoma.
Garrett T Graham, Saravana P Selvanathan, Stefan K Zöllner, Emily Stahl, Adam Shlien, Jeffrey A Toretsky

NAR Cancer· March 2022

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Clofarabine induces ERK/MSK/CREB activation through inhibiting CD99 on Ewing sarcoma cells.
Handan Sevim, Haydar Çelik, Levent Düşünceli, Ceyda S Ceyhan, Anna Molotkova, Jeffrey A Toretsky

PLoS One· November 2021

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Afebrile S. aureus bacteremia in two patients with hemophagocytic lymphohistiocytosis receiving emapalumab/dexamethasone/etoposide.
Jatinder K Singh, Michael A Terao, Susmita Sarangi, Jennifer Toth, Jeffrey A Toretsky

Pediatr Blood Cancer· August 2021

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-Linked--Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics.
Michael L Nosella, Maria Tereshchenko, Iva Pritišanac, P Andrew Chong, Jeffrey A Toretsky

J Am Chem Soc· August 2021

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Ewing Sarcoma-Diagnosis, Treatment, Clinical Challenges and Future Perspectives.
Stefan K Zöllner, James F Amatruda, Sebastian Bauer, Stéphane Collaud, Enrique de Álava, Jeffrey A Toretsky

J Clin Med· April 2021

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Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma-Derived Extracellular Vesicles for Downstream Functional Studies.
Jiantong Dong, Ryan Y Zhang, Na Sun, Junhui Hu, Matthew D Smalley, Jeffrey A Toretsky

Adv Funct Mater· December 2020

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EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex.
Saravana P Selvanathan, Garrett T Graham, Alexander R Grego, Tabari M Baker, J Robert Hogg, Jeffrey A Toretsky

Nucleic Acids Res· October 2019

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The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents.
Filippo Spriano, Elaine Yee Lin Chung, Eugenio Gaudio, Chiara Tarantelli, Luciano Cascione, Jeffrey A Toretsky

Clin Cancer Res· August 2019

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Targeted inhibition of histone deacetylase leads to suppression of Ewing sarcoma tumor growth through an unappreciated EWS-FLI1/HDAC3/HSP90 signaling axis.
Yan Ma, Michael Baltezor, Lian Rajewski, Jennifer Crow, Glenson Samuel, Jeffrey A Toretsky

J Mol Med (Berl)· July 2019

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Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.
Nathaniel D Anderson, Richard de Borja, Matthew D Young, Fabio Fuligni, Andrej Rosic, Jeffrey A Toretsky

Science· August 2018

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Author Correction: EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A Lawrence, Jeffrey A Toretsky

Nature· July 2018

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A probable primary malignant bone tumor in a pre-Columbian human humerus from Cerro Brujo, Bocas del Toro, Panamá.
Nicole E Smith-Guzmán, Jeffrey A Toretsky, Jason Tsai, Richard G Cooke

Int J Paleopathol· June 2018

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Clofarabine inhibits Ewing sarcoma growth through a novel molecular mechanism involving direct binding to CD99.
Haydar Çelik, Marika Sciandra, Bess Flashner, Elif Gelmez, Neslihan Kayraklıoğlu, Jeffrey A Toretsky

Oncogene· April 2018

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EWS-FLI1 increases transcription to cause R-loops and block BRCA1 repair in Ewing sarcoma.
Aparna Gorthi, July Carolina Romero, Eva Loranc, Lin Cao, Liesl A Lawrence, Jeffrey A Toretsky

Nature· March 2018

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Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation.
Jason Glover, Tsz-Kwong Man, Donald A Barkauskas, David Hall, Tanya Tello, Jeffrey A Toretsky

PLoS One· October 2017

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Inhibition of the oncogenic fusion protein EWS-FLI1 causes G-M cell cycle arrest and enhanced vincristine sensitivity in Ewing's sarcoma.
Stefan K Zöllner, Saravana P Selvanathan, Garrett T Graham, Ryan M T Commins, Sung Hyeok Hong, Jeffrey A Toretsky

Sci Signal· October 2017

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Combined experience of six independent laboratories attempting to create an Ewing sarcoma mouse model.
Tsion Zewdu Minas, Didier Surdez, Tahereh Javaheri, Miwa Tanaka, Michelle Howarth, Jeffrey A Toretsky

Oncotarget· May 2017

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Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities.
Branka Radic-Sarikas, Kalliopi P Tsafou, Kristina B Emdal, Theodore Papamarkou, Kilian V M Huber, Jeffrey A Toretsky

Mol Cancer Ther· January 2017

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