Publications by authors named "Jeffrey D Rothstein"

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Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion.
Thomas Philips, Emily G Thompson, Olivia Spead, Balaji G Vijayakumar, Erica R Kent, Jeffrey D Rothstein

Glia· February 2026

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Mapping the circulating proteome across neurodegeneration: A harmonized, consortium-scale framework for uncovering molecular pathophysiology.
Caitlin A Finney, Lijun An, Laura M Winchester, Jacob Vogel, Heather M Wilkins, Jeffrey D Rothstein

bioRxiv· December 2025

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Visualizing nuclear pore complex plasticity with pan-expansion microscopy.
Kimberly J Morgan, Emma Carley, Alyssa N Coyne, Jeffrey D Rothstein, C Patrick Lusk

J Cell Biol· September 2025

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The Global Neurodegeneration Proteomics Consortium: biomarker and drug target discovery for common neurodegenerative diseases and aging.
Farhad Imam, Rowan Saloner, Jacob W Vogel, Varsha Krish, Gamal Abdel-Azim, Jeffrey D Rothstein

Nat Med· August 2025

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APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases.
Artur Shvetcov, Erik C B Johnson, Laura M Winchester, Keenan A Walker, Heather M Wilkins, Jeffrey D Rothstein

Nat Med· August 2025

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Sporadic ALS induced pluripotent stem cell derived neurons reveal hallmarks of TDP-43 loss of function.
Jeffrey D Rothstein, Olivia Keeley, Caroline Warlick, Timothy M Miller, Cindy V Ly

Nat Commun· August 2025

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Divergent and convergent TMEM106B pathology in murine models of neurodegeneration and human disease.
Muzi Du, Suleyman C Akerman, Charlotte M Fare, Linhao Ruan, Svetlana Vidensky, Jeffrey D Rothstein

Acta Neuropathol Commun· August 2025

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Biobank-scale genetic characterization of Alzheimer's disease and related dementias across diverse ancestries.
Marzieh Khani, Fulya Akçimen, Spencer M Grant, Suleyman Can Akerman, Paul Suhwan Lee, Jeffrey D Rothstein

Nat Commun· August 2025

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Enterovirus D68 2A protease causes nuclear pore complex dysfunction and motor neuron toxicity.
Katrina M Zinn, Mathew W McLaren, Michael T Imai, Malavika M Jayaram, Jeffrey D Rothstein

bioRxiv· July 2025

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Large-scale differentiation of iPSC-derived motor neurons from ALS and control subjects.
Michael J Workman, Ryan G Lim, Jie Wu, Aaron Frank, Loren Ornelas, Jeffrey D Rothstein

Neuron· June 2025

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Visualizing nuclear pore complex plasticity with pan-Expansion Microscopy.
Kimberly J Morgan, Emma Carley, Alyssa N Coyne, Jeffrey D Rothstein, C Patrick Lusk

bioRxiv· April 2025

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Advances in neuromuscular disorders 2024.
Jeffrey D Rothstein, Ahmet Hoke, Payam Mohassel

Lancet Neurol· January 2025

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Identification of a Subpopulation of Astrocyte Progenitor Cells in the Neonatal Subventricular Zone: Evidence that Migration is Regulated by Glutamate Signaling.
Zila Martinez-Lozada, Alain M Guillem, Isabella Song, Michael V Gonzalez, Hajime Takano, Jeffrey D Rothstein

Neurochem Res· January 2025

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Nuclear pore dysfunction and disease: a complex opportunity.
Charlotte M Fare, Jeffrey D Rothstein

Nucleus· December 2024

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Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes.
Norah Al-Azzam, Jenny H To, Vaishali Gautam, Lena A Street, Chloe B Nguyen, Jeffrey D Rothstein

Neuron· December 2024

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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV- C9ORF72 (G 4 C 2) 66 mouse model.
Emily G Thompson, Olivia Spead, S Can Akerman, Carrie Curcio, Benjamin L Zaepfel, Jeffrey D Rothstein

Res Sq· December 2024

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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in an AAV-C9ORF72 (GC) mouse model.
Emily G Thompson, Olivia Spead, Suleyman C Akerman, Carrie Curcio, Benjamin L Zaepfel, Jeffrey D Rothstein

Acta Neuropathol Commun· December 2024

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Biobank-scale characterization of Alzheimer's disease and related dementias identifies potential disease-causing variants, risk factors, and genetic modifiers across diverse ancestries.
Marzieh Khani, Fulya Akçimen, Spencer M Grant, S Can Akerman, Paul Suhwan Lee, Jeffrey D Rothstein

medRxiv· November 2024

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Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease.
Muzi Du, Suleyman C Akerman, Charlotte M Fare, Linhao Ruan, Svetlana Vidensky, Jeffrey D Rothstein

Res Sq· November 2024

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Divergent and Convergent TMEM106B Pathology in Murine Models of Neurodegeneration and Human Disease.
Muzi Du, Suleyman C Akerman, Charlotte M Fare, Linhao Ruan, Svetlana Vidensky, Jeffrey D Rothstein

bioRxiv· October 2024

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Apilimod dimesylate in C9orf72 amyotrophic lateral sclerosis: a randomized phase 2a clinical trial.
Suma Babu, Katharine A Nicholson, Jeffrey D Rothstein, Andrea Swenson, Paul J Sampognaro

Brain· September 2024

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Investigating the Protective Role of the Mitochondrial 2158 T > C Variant in Parkinson's Disease.
Fulya Akçimen, Vesna van Midden, S Can Akerman, Mary B Makarious, , Jeffrey D Rothstein

Mov Disord· September 2024

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Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study.
Leonard H van den Berg, Jeffrey D Rothstein, Pamela J Shaw, Suma Babu, Michael Benatar

Lancet Neurol· September 2024

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A robust evaluation of TDP-43, poly GP, cellular pathology and behavior in a AAV-C9ORF72 (GC) mouse model.
Emily G Thompson, Olivia Spead, S Can Akerman, Carrie Curcio, Benjamin L Zaepfel, Jeffrey D Rothstein

bioRxiv· August 2024

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Disease related changes in ATAC-seq of iPSC-derived motor neuron lines from ALS patients and controls.
Stanislav Tsitkov, Kelsey Valentine, Velina Kozareva, Aneesh Donde, Aaron Frank, Jeffrey D Rothstein

Nat Commun· May 2024

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