Publications by authors named "Jeffrey D Singer"

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Autism risk gene alters neuronal morphology via caspase-3 activity in mouse hippocampal neurons.
Qiang-Qiang Xia, Anju Singh, Jing Wang, Zhong Xin Xuan, Jeffrey D Singer

Front Cell Neurosci· May 2024

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Effects of heterozygous deletion of autism-related gene Cullin-3 in mice.
Qiang-Qiang Xia, Angela K Walker, Chenghui Song, Jing Wang, Anju Singh, Jeffrey D Singer

PLoS One· July 2023

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Cullin 3-Mediated Regulation of Intracellular Iron Homeostasis Promotes Thymic Invariant NKT Cell Maturation.
Emily L Yarosz, Ajay Kumar, Jeffrey D Singer, Cheong-Hee Chang

Immunohorizons· March 2023

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Cul3 is required for normal development of the mammary gland.
Cristina M Cummings, Jeffrey D Singer

Cell Tissue Res· July 2021

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Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E.
Brittney Davidge, Katia Graziella de Oliveira Rebola, Larry N Agbor, Curt D Sigmund, Jeffrey D Singer

J Cell Sci· November 2019

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Conditional deletion of smooth muscle Cullin-3 causes severe progressive hypertension.
Larry N Agbor, Anand R Nair, Jing Wu, Ko-Ting Lu, Deborah R Davis, Jeffrey D Singer

JCI Insight· June 2019

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Cullin-3 dependent deregulation of ACTN1 represents a new pathogenic mechanism in nemaline myopathy.
Jordan Blondelle, Kavya Tallapaka, Jane T Seto, Majid Ghassemian, Madison Clark, Jeffrey D Singer

JCI Insight· April 2019

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Disruption of CUL3-mediated ubiquitination causes proximal tubule injury and kidney fibrosis.
Turgay Saritas, Catherina A Cuevas, Mohammed Z Ferdaus, Christoph Kuppe, Rafael Kramann, Jeffrey D Singer

Sci Rep· March 2019

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Dual gain and loss of cullin 3 function mediates familial hyperkalemic hypertension.
Ryan J Cornelius, Chong Zhang, Kayla J Erspamer, Larry N Agbor, Curt D Sigmund, Jeffrey D Singer

Am J Physiol Renal Physiol· October 2018

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Mutant Cullin 3 causes familial hyperkalemic hypertension via dominant effects.
Mohammed Z Ferdaus, Lauren N Miller, Larry N Agbor, Turgay Saritas, Jeffrey D Singer

JCI Insight· December 2017

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Myeloid-derived cullin 3 promotes STAT3 phosphorylation by inhibiting OGT expression and protects against intestinal inflammation.
Xinghui Li, Zhibin Zhang, Lupeng Li, Wei Gong, Audrey J Lazenby, Jeffrey D Singer

J Exp Med· April 2017

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Intermediate filament aggregates cause mitochondrial dysmotility and increase energy demands in giant axonal neuropathy.
Eitan Israeli, Dilyan I Dryanovski, Paul T Schumacker, Navdeep S Chandel, Jeffrey D Singer

Hum Mol Genet· June 2016

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Degradation by Cullin 3 and effect on WNK kinases suggest a role of KLHL2 in the pathogenesis of Familial Hyperkalemic Hypertension.
Chong Zhang, Nicholas P Meermeier, Andrew S Terker, Katharina I Blankenstein, Jeffrey D Singer

Biochem Biophys Res Commun· January 2016

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Hyperkalemic hypertension-associated cullin 3 promotes WNK signaling by degrading KLHL3.
James A McCormick, Chao-Ling Yang, Chong Zhang, Brittney Davidge, Katharina I Blankenstein, Jeffrey D Singer

J Clin Invest· November 2014

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Novel Cul3 binding proteins function to remodel E3 ligase complexes.
Wananit Wimuttisuk, Mark West, Brittney Davidge, Kebing Yu, Arthur Salomon, Jeffrey D Singer

BMC Cell Biol· July 2014

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A negative feedback loop mediated by the Bcl6-cullin 3 complex limits Tfh cell differentiation.
Rebecca Mathew, Ai-ping Mao, Andrew H Chiang, Clara Bertozzi-Villa, Jeffrey J Bunker, Jeffrey D Singer

J Exp Med· June 2014

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Amorphous alumina nanowire array efficiently delivers Ac-DEVD-CHO to inhibit apoptosis of dendritic cells.
Lester Lampert, Brittany Timonen, Sean Smith, Brittney Davidge, Haiyan Li, Jeffrey D Singer

Chem Commun (Camb)· February 2014

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B-Myb promotes S-phase independently of its sequence-specific DNA binding activity and interacts with polymerase delta-interacting protein 1 (Pdip1).
Eugen Werwein, Thore Schmedt, Heiko Hoffmann, Clemens Usadel, Nora Obermann, Jeffrey D Singer

Cell Cycle· November 2012

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BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
Rebecca Mathew, Michael P Seiler, Seth T Scanlon, Ai-ping Mao, Michael G Constantinides, Jeffrey D Singer

Nature· November 2012

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Designing calcium release channel inhibitors with enhanced electron donor properties: stabilizing the closed state of ryanodine receptor type 1.
Yanping Ye, Daniel Yaeger, Laura J Owen, Jorge O Escobedo, Jialu Wang, Jeffrey D Singer

Mol Pharmacol· January 2012

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BTB-Kelch proteins and ubiquitination of kainate receptors.
John Marshall, Leslie A C Blair, Jeffrey D Singer

Adv Exp Med Biol· July 2011

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The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells.
Uta Kossatz, Kai Breuhahn, Benita Wolf, Matthias Hardtke-Wolenski, Ludwig Wilkens, Stephan Singer, Jeffrey D Singer

J Clin Invest· November 2010

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Pcif1 modulates Pdx1 protein stability and pancreatic β cell function and survival in mice.
Kathryn C Claiborn, Mira M Sachdeva, Corey E Cannon, David N Groff, Jeffrey D Singer

J Clin Invest· October 2010

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The ubiquitin conjugating enzyme, UbcM2, engages in novel interactions with components of cullin-3 based E3 ligases.
Kendra S Plafker, Jeffrey D Singer, Scott M Plafker

Biochemistry· April 2009

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The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells.
Cristina M Cummings, Cornelia A Bentley, Sarah A Perdue, Peter W Baas, Jeffrey D Singer

J Biol Chem· April 2009

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