Publications by authors named "Jeffrey D Steimle"

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Gene therapy CM-YAP protects the mouse heart from myocardial infarction.
Fansen Meng, Jeffrey D Steimle, Elizabeth Straight, Rich G Li, Yuka Morikawa

Nat Cardiovasc Res· December 2025

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PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.
Lieve E van der Maarel, M Ridwane Mungroo, Otto J Mulleners, Mathilde R Rivaud, Arie O Verkerk, Jeffrey D Steimle

Nat Commun· December 2025

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SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling.
Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang

Elife· September 2025

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SARS-CoV-2 NSP13 interacts with TEAD to suppress Hippo-YAP signaling.
Fansen Meng, Jong Hwan Kim, Chang-Ru Tsai, Jeffrey D Steimle, Jun Wang

bioRxiv· June 2025

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Microtubules Sequester Acetylated YAP in the Cytoplasm and Inhibit Heart Regeneration.
Shijie Liu, Vaibhav Deshmukh, Fansen Meng, Yidan Wang, Yuka Morikawa, Jeffrey D Steimle

Circulation· January 2025

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Single-nuclei transcriptomics reveals TBX5-dependent targets in a patient with Holt-Oram syndrome.
Jeffrey D Steimle, Yi Zhao, Fansen Meng, Mikaela E Taylor, Diwakar Turaga

J Clin Invest· November 2024

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A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network.
Michael T Broman, Rangarajan D Nadadur, Carlos Perez-Cervantes, Ozanna Burnicka-Turek, Sonja Lazarevic, Jeffrey D Steimle

Circulation· April 2024

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Endothelial cells adopt a pro-reparative immune responsive signature during cardiac injury.
Hali Long, Jeffrey D Steimle, Francisco Jose Grisanti Canozo, Jong Hwan Kim, Xiao Li

Life Sci Alliance· February 2024

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Sweet and sour story of maternal diabetes and birth defects.
Jeffrey D Steimle, James F Martin

Nat Cardiovasc Res· December 2023

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ETV2 primes hematoendothelial gene enhancers prior to hematoendothelial fate commitment.
Jeffrey D Steimle, Chul Kim, Megan Rowton, Rangarajan D Nadadur, Zhezhen Wang

Cell Rep· June 2023

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Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization.
Kevin R Bersell, Tao Yang, Jonathan D Mosley, Andrew M Glazer, Andrew T Hale, Jeffrey D Steimle

Circulation· March 2023

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Regrowing the heart, one TREE at a time.
Jeffrey D Steimle, James F Martin

Cell Stem Cell· January 2023

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Hedgehog signaling activates a mammalian heterochronic gene regulatory network controlling differentiation timing across lineages.
Megan Rowton, Carlos Perez-Cervantes, Suzy Hur, Jessica Jacobs-Li, Emery Lu, Jeffrey D Steimle

Dev Cell· September 2022

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LATS1/2 control TGFB-directed epithelial-to-mesenchymal transition in the murine dorsal cranial neuroepithelium through YAP regulation.
Idaliz M Martínez Traverso, Jeffrey D Steimle, Xiaolei Zhao, Jun Wang, James F Martin

Development· September 2022

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Decoding the PITX2-controlled genetic network in atrial fibrillation.
Jeffrey D Steimle, Francisco J Grisanti Canozo, Minjun Park, Zachary A Kadow, Md Abul Hassan Samee

JCI Insight· June 2022

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Tbx5 drives expression to regulate a RA-Hedgehog-Wnt gene regulatory network coordinating cardiopulmonary development.
Scott A Rankin, Jeffrey D Steimle, Xinan H Yang, Ariel B Rydeen, Kunal Agarwal

Elife· October 2021

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Enhancing Pace: Identifying and Validating the Cis-Regulatory Landscape of the Sinoatrial Node.
Jeffrey D Steimle, Chang-Ru Tsai, James F Martin

Circ Res· December 2020

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Transcriptional Patterning of the Ventricular Cardiac Conduction System.
Ozanna Burnicka-Turek, Michael T Broman, Jeffrey D Steimle, Bastiaan J Boukens, Nataliya B Petrenko

Circ Res· July 2020

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Evolutionarily conserved - pathway orchestrates cardiopulmonary development.
Jeffrey D Steimle, Scott A Rankin, Christopher E Slagle, Jenna Bekeny, Ariel B Rydeen

Proc Natl Acad Sci U S A· November 2018

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Correction: Foxf Genes Integrate Tbx5 and Hedgehog Pathways in the Second Heart Field for Cardiac Septation.
Andrew D Hoffmann, Xinan Holly Yang, Ozanna Burnicka-Turek, Joshua D Bosman, Xiaomeng Ren, Jeffrey D Steimle

PLoS Genet· December 2016

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Cilia gene mutations cause atrioventricular septal defects by multiple mechanisms.
Ozanna Burnicka-Turek, Jeffrey D Steimle, Wenhui Huang, Lindsay Felker, Anna Kamp

Hum Mol Genet· July 2016

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De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.
James R Priest, Kazutoyo Osoegawa, Nebil Mohammed, Vivek Nanda, Ramendra Kundu, Jeffrey D Steimle

PLoS Genet· April 2016

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The Cardiac TBX5 Interactome Reveals a Chromatin Remodeling Network Essential for Cardiac Septation.
Lauren Waldron, Jeffrey D Steimle, Todd M Greco, Nicholas C Gomez, Kerry M Dorr

Dev Cell· February 2016

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The pattern of congenital heart defects arising from reduced Tbx5 expression is altered in a Down syndrome mouse model.
Renita C Polk, Peter Gergics, Jeffrey D Steimle, Huiqing Li, Ivan P Moskowitz

BMC Dev Biol· July 2015

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Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation.
Andrew D Hoffmann, Xinan Holly Yang, Ozanna Burnicka-Turek, Joshua D Bosman, Xiaomeng Ren, Jeffrey D Steimle

PLoS Genet· October 2014

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