Publications by authors named "Jeffrey MacDonald"

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Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex.
Kuldeep Kumar, Sayeh Kazem, Guillaume Huguet, Worrawat Engchuan, Jakub Kopal, Jeffrey R MacDonald

bioRxiv· November 2025

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Determinants of pleiotropy and monotonic gene dosage responses across human traits.
Sayeh Kazem, Kuldeep Kumar, Guillaume Huguet, Josephine Mollon, Thomas Renne, Jeffrey R MacDonald

Res Sq· November 2025

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Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex.
Kuldeep Kumar, Sayeh Kazem, Guillaume Huguet, Worrawat Engchuan, Jakub Kopal, Jeffrey MacDonald

Res Sq· November 2025

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Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects.
Worrawat Engchuan, Omar Shanta, Kuldeep Kumar, Jeffrey R MacDonald, Bhooma Thiruvahindrapuram

medRxiv· July 2025

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A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits.
Omar Shanta, Marieke Klein, Molly Sacks, Jeffrey R MacDonald, Adam Maihofer

medRxiv· July 2025

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Gene dosage architecture across complex traits.
Sayeh Kazem, Kuldeep Kumar, Martineau Jean-Louis, Guillaume Huguet, Thomas Renne, Jeffrey R MacDonald

medRxiv· February 2025

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Comprehensive whole-genome sequence analyses provide insights into the genomic architecture of cerebral palsy.
Darcy L Fehlings, Mehdi Zarrei, Worrawat Engchuan, Neal Sondheimer, Bhooma Thiruvahindrapuram, Jeffrey R MacDonald

Nat Genet· April 2024

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Genetic variants in contribute to Autism Spectrum Disorder associated with the Xp22.11 locus.
Marcello Scala, Clarrisa A Bradley, Jennifer L Howe, Brett Trost, Nelson Bautista Salazar, Jeffrey R MacDonald

medRxiv· December 2023

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Gene copy number variation and pediatric mental health/neurodevelopment in a general population.
Mehdi Zarrei, Christie L Burton, Worrawat Engchuan, Edward J Higginbotham, John Wei, Jeffrey R MacDonald

Hum Mol Genet· July 2023

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Author Correction: Nano-fibre Integrated Microcapsules: A Nano-in-Micro Platform for 3D Cell Culture.
Shalil Khanal, Shanta R Bhattarai, Jagannathan Sankar, Ramji K Bhandari, Jeffrey M Macdonald

Sci Rep· January 2023

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Rare copy number variation in posttraumatic stress disorder.
Adam X Maihofer, Worrawat Engchuan, Guillaume Huguet, Marieke Klein, Jeffrey R MacDonald

Mol Psychiatry· December 2022

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Genomic architecture of autism from comprehensive whole-genome sequence annotation.
Brett Trost, Bhooma Thiruvahindrapuram, Ada J S Chan, Worrawat Engchuan, Edward J Higginbotham, Jeffrey R MacDonald

Cell· November 2022

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Genome-wide rare variant score associates with morphological subtypes of autism spectrum disorder.
Ada J S Chan, Worrawat Engchuan, Miriam S Reuter, Zhuozhi Wang, Bhooma Thiruvahindrapuram, Jeffrey R MacDonald

Nat Commun· October 2022

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Direct Detection of Glutathione Biosynthesis, Conjugation, Depletion and Recovery in Intact Hepatoma Cells.
Rex E Jeffries, Shawn M Gomez, Jeffrey M Macdonald, Michael P Gamcsik

Int J Mol Sci· April 2022

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Green Chemistry Preservation and Extraction of Biospecimens for Multi-omic Analyses.
Andrey P Tikunov, Jeremiah D Tipton, Timothy J Garrett, Sachi V Shinde, Hong Jin Kim, Jeffrey M Macdonald

Methods Mol Biol· March 2022

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Author Correction: Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
Kirsten L Bryant, Clint A Stalnecker, Daniel Zeitouni, Jennifer E Klomp, Sen Peng, Jeffrey M Macdonald

Nat Med· June 2020

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Lyn regulates creatine uptake in an imatinib-resistant CML cell line.
Denis O Okumu, Lucas J Aponte-Collazo, Brian J Dewar, Nathan J Cox, Michael P East, Jeffrey M Macdonald

Biochim Biophys Acta Gen Subj· April 2020

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Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile.
Kelsey A Behrens, Leigh A Jania, John N Snouwaert, MyTrang Nguyen, Sheryl S Moy, Jeffrey M Macdonald

PLoS One· March 2020

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A large data resource of genomic copy number variation across neurodevelopmental disorders.
Mehdi Zarrei, Christie L Burton, Worrawat Engchuan, Edwin J Young, Edward J Higginbotham, Jeffrey R MacDonald

NPJ Genom Med· October 2019

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Nano-fibre Integrated Microcapsules: A Nano-in-Micro Platform for 3D Cell Culture.
Shalil Khanal, Shanta R Bhattarai, Jagannathan Sankar, Ramji K Bhandari, Jeffrey M Macdonald

Sci Rep· September 2019

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Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer.
Kirsten L Bryant, Clint A Stalnecker, Daniel Zeitouni, Jennifer E Klomp, Sen Peng, Jeffrey M Macdonald

Nat Med· April 2019

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Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.
Xuchu Que, Ming-Yow Hung, Calvin Yeang, Ayelet Gonen, Thomas A Prohaska, Jeffrey G MacDonald

Nature· September 2018

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Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.
Xuchu Que, Ming-Yow Hung, Calvin Yeang, Ayelet Gonen, Thomas A Prohaska, Jeffrey G MacDonald

Nature· June 2018

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The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants.
Miriam S Reuter, Susan Walker, Bhooma Thiruvahindrapuram, Joe Whitney, Iris Cohn, Jeffrey R MacDonald

CMAJ· February 2018

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