Publications by authors named "Jeffrey Rybak"

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Accumulation of Trehalose 6-Phosphate in Candidozyma auris results in Decreased Echinocandin Resistance and Tolerance.
Qingjuan Zhu, Sien Van de Velde, Stefanie Wijnants, Hans Carolus, Stef Jacobs, Jeffrey M Rybak

Nat Commun· December 2025

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Acquired amphotericin B resistance attributed to a mutated in .
Lauryn Massic, Laura A Doorley, Sarah J Jones, Irene Richardson, Danielle Denise Siao, Jeffrey M Rybak

Antimicrob Agents Chemother· November 2025

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Mutations in drive increased and expression and azole resistance in .
Katherine S Barker, Darian J Santana, Qing Zhang, Tracy L Peters, Jeffrey M Rybak

Antimicrob Agents Chemother· October 2025

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A systematic comparison of CRISPR-Cas9 allele editing in Candida auris demonstrates unreliable cassette integration and effective episomal plasmid-based editing.
Dimitrios Sofras, Hans Carolus, Ana Subotić, Celia Lobo Romero, Craig L Ennis, Jeffrey M Rybak

Sci Rep· October 2025

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Relative contributions of the ERG11 and MRR1A mutations to fluconazole resistance in Clade III Candidozyma (Candida) auris clinical isolates.
Katherine S Barker, Qing Zhang, Tracy L Peters, Jeffrey M Rybak, Joachim Morschhäuser

Clin Microbiol Infect· October 2025

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A Candidozyma (Candida) auris-Optimized Episomal Plasmid-Induced Cas9-Editing System Reveals the Direct Impact of the S639F-Encoding FKS1 Mutation.
Laura A Doorley, Vanessa Meza-Perez, Sarah J Jones, Jeffrey M Rybak

J Infect Dis· September 2025

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Multi-Omics Analysis of Experimentally Evolved Candida auris Isolates Reveals Modulation of Sterols, Sphingolipids, and Oxidative Stress in Acquired Amphotericin B Resistance.
Anshu Chauhan, Hans Carolus, Dimitrios Sofras, Mohit Kumar, Praveen Kumar, Jeffrey M Rybak

Mol Microbiol· August 2025

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Acquired Amphotericin B Resistance Attributed to a Mutated in .
Lauryn Massic, Laura A Doorley, Sarah J Jones, Irene Richardson, Danielle Denise Siao, Jeffrey M Rybak

bioRxiv· April 2025

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Mutations in TAC1B drive CDR1 and MDR1 expression and azole resistance in C. auris.
Katherine S Barker, Darian J Santana, Qing Zhang, Tracy L Peters, Jeffrey Rybak

bioRxiv· February 2025

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A ( ) -optimized Episomal Plasmid Induced Cas9-editing system reveals the direct impact of the S639F encoding mutation.
Laura A Doorley, Vanessa Meza-Perez, Sarah J Jones, Jeffrey M Rybak

bioRxiv· February 2025

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A comparative evaluation of CRISPR-Cas9 allele editing systems in : challenging research in a challenging bug.
Dimitrios Sofras, Hans Carolus, Ana Subotić, Celia Lobo Romero, Craig L Ennis, Jeffrey M Rybak

bioRxiv· January 2025

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Acquired amphotericin B resistance leads to fitness trade-offs that can be mitigated by compensatory evolution in Candida auris.
Hans Carolus, Dimitrios Sofras, Giorgio Boccarella, Poppy Sephton-Clark, Vladislav Biriukov, Jeffrey M Rybak

Nat Microbiol· December 2024

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Analysis of clinical isolates reveals copy number variation in key fluconazole resistance genes.
Sean Bergin, Laura A Doorley, Jeffrey M Rybak, Kenneth H Wolfe, Geraldine Butler

Antimicrob Agents Chemother· June 2024

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The small molecule CBR-5884 inhibits the phosphatidylserine synthase.
Yue Zhou, Gregory A Phelps, Mikayla M Mangrum, Jemma McLeish, Elise K Phillips, Jeffrey M Rybak

mBio· May 2024

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The sterol C-24 methyltransferase encoding gene, erg6, is essential for viability of Aspergillus species.
Jinhong Xie, Jeffrey M Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I Thorn

Nat Commun· May 2024

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A secondary mechanism of action for triazole antifungals in Aspergillus fumigatus mediated by hmg1.
Jeffrey M Rybak, Jinhong Xie, Adela Martin-Vicente, Xabier Guruceaga, Harrison I Thorn

Nat Commun· April 2024

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Mutations in TAC1 and ERG11 are major drivers of triazole antifungal resistance in clinical isolates of Candida parapsilosis.
Laura A Doorley, Katherine S Barker, Qing Zhang, Jeffrey M Rybak, P David Rogers

Clin Microbiol Infect· December 2023

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Analysis of clinical isolates reveals copy number variation in key fluconazole resistance genes.
Sean Bergin, Laura A Doorley, Jeffrey M Rybak, Kenneth H Wolfe, Geraldine Butler

bioRxiv· December 2023

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The sterol C-24 methyltransferase encoding gene, , is essential for viability of species.
Jinhong Xie, Jeffrey M Rybak, Adela Martin-Vicente, Xabier Guruceaga, Harrison I Thorn

bioRxiv· August 2023

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and Mutations Are Drivers of -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate.
Ana C O Souza, Wenbo Ge, Nathan P Wiederhold, Jeffrey M Rybak, Jarrod R Fortwendel

Microbiol Spectr· June 2023

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Candida parapsilosis Mdr1B and Cdr1B Are Drivers of Mrr1-Mediated Clinical Fluconazole Resistance.
Laura A Doorley, Jeffrey M Rybak, Elizabeth L Berkow, Qing Zhang, Joachim Morschhäuser

Antimicrob Agents Chemother· July 2022

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In vivo emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in Candida auris.
Jeffrey M Rybak, Katherine S Barker, José F Muñoz, Josie E Parker, Suhail Ahmad

Clin Microbiol Infect· June 2022

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Rapid Hypothesis Testing in Candida albicans Clinical Isolates Using a Cloning-Free, Modular, and Recyclable System for CRISPR-Cas9 Mediated Mutant and Revertant Construction.
Junyan Liu, Amanda K Vogel, Jian Miao, Jennifer A Carnahan, David J Lowes, Jeffrey M Rybak

Microbiol Spectr· June 2022

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Delineation of the Direct Contribution of Candida auris Mutations to Clinical Triazole Resistance.
Jeffrey M Rybak, Cheshta Sharma, Laura A Doorley, Katherine S Barker, Glen E Palmer

Microbiol Spectr· December 2021

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