Publications by authors named "Jennifer E Howes"

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Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
Jonathan D Macdonald, Selena Chacón Simon, Changho Han, Feng Wang, J Grace Shaw, Jennifer E Howes

J Med Chem· December 2019

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Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.
Denis T Akan, Jennifer E Howes, Jiqing Sai, Allison L Arnold, Yugandhar Beesetty

ACS Chem Biol· March 2019

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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
Timothy R Hodges, Jason R Abbott, Andrew J Little, Dhruba Sarkar, James M Salovich, Jennifer E Howes

J Med Chem· October 2018

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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
Jason R Abbott, Pratiq A Patel, Jennifer E Howes, Denis T Akan, J Phillip Kennedy

ACS Med Chem Lett· September 2018

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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
Jason R Abbott, Timothy R Hodges, R Nathan Daniels, Pratiq A Patel, J Phillip Kennedy, Jennifer E Howes

J Med Chem· July 2018

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Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1.
Jennifer E Howes, Denis T Akan, Michael C Burns, Olivia W Rossanese, Alex G Waterson

Mol Cancer Ther· May 2018

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High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling.
Michael C Burns, Jennifer E Howes, Qi Sun, Andrew J Little, DeMarco V Camper

Anal Biochem· May 2018

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