Publications by authors named "Jennifer Golas"

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Osteogenic effects of a potent Src-over-Abl-selective kinase inhibitor in the mouse.
Richard J Murrills, Shoichi Fukayama, Frank Boschelli, Jeanne J Matteo, Jane Owens, Jennifer M Golas

J Pharmacol Exp Ther· March 2012

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Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model.
Christoph W Zapf, Jonathan D Bloom, Zhong Li, Russell G Dushin, Thomas Nittoli, Jennifer M Golas

Bioorg Med Chem Lett· August 2011

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Macrocyclic lactams as potent Hsp90 inhibitors with excellent tumor exposure and extended biomarker activity.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Thomas Nittoli, Jennifer M Golas

Bioorg Med Chem Lett· June 2011

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Discovery of a macrocyclic o-aminobenzamide Hsp90 inhibitor with heterocyclic tether that shows extended biomarker activity and in vivo efficacy in a mouse xenograft model.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Jennifer M Golas

Bioorg Med Chem Lett· June 2011

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Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity.
Christoph W Zapf, Jonathan D Bloom, Jamie L McBean, Russell G Dushin, Thomas Nittoli, Jennifer Golas

Bioorg Med Chem Lett· April 2011

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A cell-based screen for inhibitors of protein folding and degradation.
Frank Boschelli, Jennifer M Golas, Roseann Petersen, Vincent Lau, Lei Chen

Cell Stress Chaperones· November 2010

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Optimization of 7-alkene-3-quinolinecarbonitriles as Src kinase inhibitors.
Diane H Boschelli, Daniel Wang, Yan Wang, Biqi Wu, Erick E Honores, Jennifer Golas

Bioorg Med Chem Lett· May 2010

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4-Anilino-7-pyridyl-3-quinolinecarbonitriles as Src kinase inhibitors.
Nan Zhang, Biqi Wu, Diane H Boschelli, Jennifer M Golas, Frank Boschelli

Bioorg Med Chem Lett· September 2009

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Discovery of benzisoxazoles as potent inhibitors of chaperone heat shock protein 90.
Ariamala Gopalsamy, Mengxiao Shi, Jennifer Golas, Erik Vogan, Jaison Jacob

J Med Chem· February 2008

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Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates: identification of potent 7-amino analogs.
Diane H Boschelli, Biqi Wu, Fei Ye, Haris Durutlic, Jennifer M Golas

Bioorg Med Chem· January 2008

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Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of SKS-927.
Diane H Boschelli, Ana Carolina Barrios Sosa, Jennifer M Golas, Frank Boschelli

Bioorg Med Chem Lett· March 2007

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Synthesis and Src kinase inhibitory activity of a series of 4-[(2,4-dichloro-5-methoxyphenyl)amino]-7-furyl-3-quinolinecarbonitriles.
Diane H Boschelli, Biqi Wu, Fei Ye, Yan Wang, Jennifer M Golas

J Med Chem· December 2006

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7-(aryl/heteroaryl-2-ylethynyl)-4-phenylamino-3-quinolinecarbonitriles as new Src kinase inhibitors: addition of water solubilizing groups.
Biqi Wu, Ana Carolina Barrios Sosa, Diane H Boschelli, Frank Boschelli, Erick E Honores, Jennifer M Golas

Bioorg Med Chem Lett· August 2006

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Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles.
Diane H Boschelli, Biqi Wu, Ana Carolina Barrios Sosa, Joan J Chen, Jennifer M Golas

Bioorg Med Chem Lett· November 2005

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4-Anilino-7,8-dialkoxybenzo[g]quinoline-3-carbonitriles as potent Src kinase inhibitors.
Dan M Berger, Minu Dutia, Gary Birnberg, Dennis Powell, Diane H Boschelli, Jennifer Golas

J Med Chem· September 2005

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Synthesis and Src kinase inhibitory activity of 2-phenyl- and 2-thienyl-7-phenylaminothieno[3,2-b]pyridine-6-carbonitriles.
Diane H Boschelli, Biqi Wu, Ana Carolina Barrios Sosa, Haris Durutlic, Joan J Chen, Jennifer M Golas

J Med Chem· June 2005

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SKI-606, a Src/Abl inhibitor with in vivo activity in colon tumor xenograft models.
Jennifer M Golas, Judy Lucas, Carlo Etienne, Jonathan Golas, Carolyn Discafani

Cancer Res· June 2005

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Further studies on ethenyl and ethynyl-4-phenylamino-3-quinolinecarbonitriles: identification of a subnanomolar Src kinase inhibitor.
Ana Carolina Barrios Sosa, Diane H Boschelli, Biqi Wu, Yan Wang, Jennifer M Golas

Bioorg Med Chem Lett· March 2005

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Identification of 7-phenylaminothieno- [3,2-b]pyridine-6-carbonitriles as a new class of Src kinase inhibitors.
Diane H Boschelli, Biqi Wu, Ana Carolina Barrios Sosa, Haris Durutlic, Fei Ye, Jennifer M Golas

J Med Chem· December 2004

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Synthesis and inhibition of Src kinase activity by 7-ethenyl and 7-ethynyl-4-anilino-3-quinolinecarbonitriles.
Ana Carolina Barrios Sosa, Diane H Boschelli, Fei Ye, Jennifer M Golas, Frank Boschelli

Bioorg Med Chem Lett· May 2004

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7-Alkoxy-4-phenylamino-3-quinolinecar-bonitriles as dual inhibitors of Src and Abl kinases.
Diane H Boschelli, Yanong D Wang, Steve Johnson, Biqi Wu, Fei Ye, Jennifer M Golas

J Med Chem· March 2004

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Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity.
Diane H Boschelli, Fei Ye, Biqi Wu, Yanong D Wang, Ana Carolina Barrios Sosa, Jennifer M Golas

Bioorg Med Chem Lett· November 2003

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Inhibition of Src kinase activity by 4-anilino-5,10-dihydro-pyrimido[4,5-b]quinolines.
Diane H Boschelli, Dennis Powell, Jennifer M Golas, Frank Boschelli

Bioorg Med Chem Lett· September 2003

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SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.
Jennifer M Golas, Kim Arndt, Carlo Etienne, Judy Lucas, Danielle Nardin

Cancer Res· January 2003

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