Publications by authors named "Jennifer Linderman"

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Inference of weak-form partial differential equations describing migration and proliferation mechanisms in wound healing experiments on cancer cells.
Siddhartha Srivastava, Patrick C Kinnunen, Zhenlin Wang, Kenneth K Y Ho, Brock A Humphries, Jennifer J Linderman

PLoS Comput Biol· October 2025

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Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden.
Christian T Michael, Maral Budak, Pauline Maiello, Kara Kracinovsky, Mark Rodgers, Jennifer J Linderman

J Theor Biol· August 2025

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Inference of weak-form partial differential equations describing migration and proliferation mechanisms in wound healing experiments on cancer cells.
Patrick C Kinnunen, Siddhartha Srivastava, Zhenlin Wang, Kenneth K Y Ho, Brock A Humphries, Jennifer J Linderman

ArXiv· October 2024

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Optimizing Solid Tumor Treatment with Antibody-drug Conjugates Using Agent-Based Modeling: Considering the Role of a Carrier Dose and Payload Class.
Melissa C Calopiz, Jennifer J Linderman, Greg M Thurber

Pharm Res· June 2024

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Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays.
Patrick C Kinnunen, Brock A Humphries, Gary D Luker, Kathryn E Luker, Jennifer J Linderman

NPJ Syst Biol Appl· April 2024

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Auto-tuning of Antibody-Drug Conjugate Delivery for Effective Immunotherapy using High-Avidity, Low-Affinity Antibodies.
Anna Kopp, Shujun Dong, Hyeyoung Kwon, Tiexin Wang, Alec A Desai, Jennifer J Linderman

bioRxiv· April 2024

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Integrating inverse reinforcement learning into data-driven mechanistic computational models: a novel paradigm to decode cancer cell heterogeneity.
Patrick C Kinnunen, Kenneth K Y Ho, Siddhartha Srivastava, Chengyang Huang, Wanggang Shen, Jennifer J Linderman

Front Syst Biol· March 2024

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A framework for multi-scale intervention modeling: virtual cohorts, virtual clinical trials, and model-to-model comparisons.
Christian T Michael, Sayed Ahmad Almohri, Jennifer J Linderman, Denise E Kirschner

Front Syst Biol· January 2024

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Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens.
Maral Budak, Joseph M Cicchese, Pauline Maiello, H Jacob Borish, Alexander G White, Jennifer J Linderman

PLoS Comput Biol· June 2023

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Computational modeling implicates protein scaffolding in p38 regulation of Akt.
Patrick C Kinnunen, Gary D Luker, Kathryn E Luker, Jennifer J Linderman

J Theor Biol· December 2022

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Concomitant immunity to M. tuberculosis infection.
Louis R Joslyn, JoAnne L Flynn, Denise E Kirschner, Jennifer J Linderman

Sci Rep· December 2022

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Pharmacokinetics and Pharmacodynamics of TAK-164 Antibody Drug Conjugate Coadministered with Unconjugated Antibody.
Bruna Menezes, Eshita Khera, Melissa Calopiz, Michael D Smith, Michelle L Ganno, Jennifer J Linderman

AAPS J· October 2022

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Co-optimization of therapeutic antibody affinity and specificity using machine learning models that generalize to novel mutational space.
Emily K Makowski, Patrick C Kinnunen, Jie Huang, Lina Wu, Matthew D Smith, Jennifer J Linderman

Nat Commun· July 2022

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A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes.
Louis R Joslyn, Jennifer J Linderman, Denise E Kirschner

J Theor Biol· April 2022

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Simulating the Selection of Resistant Cells with Bystander Killing and Antibody Coadministration in Heterogeneous Human Epidermal Growth Factor Receptor 2-Positive Tumors.
Bruna Menezes, Jennifer J Linderman, Greg M Thurber

Drug Metab Dispos· January 2022

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Neutrophil Dynamics Affect Granuloma Outcomes and Dissemination.
Caitlin Hult, Joshua T Mattila, Hannah P Gideon, Jennifer J Linderman, Denise E Kirschner

Front Immunol· December 2021

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Corrigendum: Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within  Granulomas.
Jess A Millar, J Russell Butler, Stephanie Evans, Nicole L Grant, Joshua T Mattila, Jennifer J Linderman

Front Immunol· November 2021

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Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Granulomas.
Jess A Millar, J Russell Butler, Stephanie Evans, Joshua T Mattila, Jennifer J Linderman

Front Immunol· June 2021

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Computational methods for characterizing and learning from heterogeneous cell signaling data.
Patrick C Kinnunen, Kathryn E Luker, Gary D Luker, Jennifer J Linderman

Curr Opin Syst Biol· June 2021

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A multi-scale pipeline linking drug transcriptomics with pharmacokinetics predicts in vivo interactions of tuberculosis drugs.
Joseph M Cicchese, Awanti Sambarey, Denise Kirschner, Jennifer J Linderman, Sriram Chandrasekaran

Sci Rep· March 2021

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: A Calibration Protocol That Utilizes Parameter Density Estimation to Explore Parameter Space and Calibrate Complex Biological Models.
Louis R Joslyn, Denise E Kirschner, Jennifer J Linderman

Cell Mol Bioeng· February 2021

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Pre-existing Cell States Control Heterogeneity of Both EGFR and CXCR4 Signaling.
Phillip C Spinosa, Patrick C Kinnunen, Brock A Humphries, Gary D Luker, Kathryn E Luker, Jennifer J Linderman

Cell Mol Bioeng· February 2021

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A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination.
Timothy Wessler, Louis R Joslyn, H Jacob Borish, Hannah P Gideon, JoAnne L Flynn, Jennifer J Linderman

PLoS Comput Biol· May 2020

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Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas.
Joseph M Cicchese, Véronique Dartois, Denise E Kirschner, Jennifer J Linderman

Front Pharmacol· March 2020

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Global sensitivity analysis of biological multi-scale models.
Marissa Renardy, Caitlin Hult, Stephanie Evans, Jennifer J Linderman, Denise E Kirschner

Curr Opin Biomed Eng· September 2019

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