Publications by authors named "Jennifer Littlechild"

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Triosephosphate isomerase from Fasciola hepatica: high-resolution crystal structure as a drug target.
Georgios Kontellas, David J Studholme, Mark van der Giezen, David J Timson, Jennifer A Littlechild

Acta Crystallogr F Struct Biol Commun· September 2025

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Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering.
Stefania Patti, Simone A De Rose, Michail N Isupov, Ilaria Magrini Alunno, Sergio Riva, Jennifer A Littlechild

Appl Microbiol Biotechnol· August 2025

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Establishment of an efficient one-step enzymatic synthesis of cyclic-2,3-diphosphoglycerate.
Christina Stracke, Benjamin H Meyer, Simone A De Rose, Erica Elisa Ferrandi, Ilya V Kublanov, Jennifer Littlechild

Front Microbiol· May 2025

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Structural characterization of a novel cyclic 2,3-diphosphoglycerate synthetase involved in extremolyte production in the archaeon .
Simone A De Rose, Michail N Isupov, Harley L Worthy, Christina Stracke, Nicholas J Harmer, Jennifer A Littlechild

Front Microbiol· November 2023

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Editorial: Systems biocatalysis for bioprocess design.
Roland Wohlgemuth, Jennifer Littlechild, Byung-Gee Kim

Front Bioeng Biotechnol· November 2022

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Complexity reduction and opportunities in the design, integration and intensification of biocatalytic processes for metabolite synthesis.
Roland Wohlgemuth, Jennifer Littlechild

Front Bioeng Biotechnol· July 2022

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Biocatalysis as Key to Sustainable Industrial Chemistry.
Andrés R Alcántara, Pablo Domínguez de María, Jennifer A Littlechild, Martin Schürmann, Roger A Sheldon

ChemSusChem· May 2022

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Biocatalysis as Key to Sustainable Industrial Chemistry.
Andrés R Alcántara, Pablo Domínguez de María, Jennifer A Littlechild, Martin Schürmann, Roger A Sheldon

ChemSusChem· May 2022

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Preface to Special Issue on Biocatalysis as Key to Sustainable Industrial Chemistry.
Andrés R Alcántara, Pablo Domínguez de María, Jennifer A Littlechild, Martin Schürmann, Roger A Sheldon

ChemSusChem· May 2022

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Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon sp.
Simone Antonio De Rose, Tom Kuprat, Michail N Isupov, Andreas Reinhardt, Peter Schönheit, Jennifer A Littlechild

Front Bioeng Biotechnol· August 2021

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Structural Insights into a Novel Esterase from the East Pacific Rise and Its Improved Thermostability by a Semirational Design.
Chunhua Zhu, Yayu Chen, Michail N Isupov, Jennifer A Littlechild, Lifang Sun

J Agric Food Chem· January 2021

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Structural insights into the NAD-dependent formate dehydrogenase mechanism revealed from the NADH complex and the formate NAD ternary complex of the Chaetomium thermophilum enzyme.
Berin Yilmazer, Michail N Isupov, Simone A De Rose, Huri Bulut, Jens C Benninghoff, Jennifer A Littlechild

J Struct Biol· December 2020

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Biosensors and Diagnostics for Fungal Detection.
Khalil K Hussain, Dhara Malavia, Elizabeth M Johnson, Jennifer Littlechild, C Peter Winlove

J Fungi (Basel)· December 2020

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A 'Split-Gene' Transketolase From the Hyper-Thermophilic Bacterium : Structure and Biochemical Characterization.
Paul James, Michail N Isupov, Simone Antonio De Rose, Christopher Sayer, Isobel S Cole, Jennifer A Littlechild

Front Microbiol· October 2020

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The crystal structure of Arabidopsis BON1 provides insights into the copine protein family.
Qianchao Wang, Meiqin Jiang, Michail N Isupov, Yayu Chen, Jennifer A Littlechild

Plant J· August 2020

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Using enzyme cascades in biocatalysis: Highlight on transaminases and carboxylic acid reductases.
Rhys Cutlan, Simone De Rose, Michail N Isupov, Jennifer A Littlechild, Nicholas J Harmer

Biochim Biophys Acta Proteins Proteom· February 2020

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Engineering a Seven Enzyme Biotransformation using Mathematical Modelling and Characterized Enzyme Parts.
William Finnigan, Rhys Cutlan, Radka Snajdrova, Joseph P Adams, Jennifer A Littlechild

ChemCatChem· August 2019

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Structural basis for the Target DNA recognition and binding by the MYB domain of phosphate starvation response 1.
Meiqin Jiang, Lifang Sun, Michail N Isupov, Jennifer A Littlechild, Xiuling Wu

FEBS J· July 2019

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Corrigendum: Thermostable Branched-Chain Amino Acid Transaminases From the Archaea and : Biochemical and Structural Characterization.
Michail N Isupov, Konstantin M Boyko, Jan-Moritz Sutter, Paul James, Christopher Sayer, Jennifer A Littlechild

Front Bioeng Biotechnol· April 2019

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X-ray structure of Fasciola hepatica Sigma class glutathione transferase 1 reveals a disulfide bond to support stability in gastro-intestinal environment.
Kirsty Line, Michail N Isupov, E James LaCourse, David J Cutress, Russell M Morphew, Jennifer A Littlechild

Sci Rep· January 2019

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Thermostable Branched-Chain Amino Acid Transaminases From the Archaea and : Biochemical and Structural Characterization.
Michail N Isupov, Konstantin M Boyko, Jan-Moritz Sutter, Paul James, Christopher Sayer, Jennifer A Littlechild

Front Bioeng Biotechnol· January 2019

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Discovering novel hydrolases from hot environments.
Roland Wohlgemuth, Jennifer Littlechild, Daniela Monti, Kirk Schnorr, Teunke van Rossum

Biotechnol Adv· December 2018

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Structural characterization of geranylgeranyl pyrophosphate synthase GACE1337 from the hyperthermophilic archaeon Geoglobus acetivorans.
Tatiana E Petrova, Konstantin M Boyko, Alena Yu Nikolaeva, Tatiana N Stekhanova, Eugeny V Gruzdev, Jennifer A Littlechild

Extremophiles· November 2018

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New Thermophilic α/β Class Epoxide Hydrolases Found in Metagenomes From Hot Environments.
Erica Elisa Ferrandi, Christopher Sayer, Simone Antonio De Rose, Elisa Guazzelli, Carlotta Marchesi, Jennifer A Littlechild

Front Bioeng Biotechnol· October 2018

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The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase. Corrigendum.
Michail N Isupov, Ewald Schröder, Robert P Gibson, Jean Beecher, Giuliana Donadio, Jennifer A Littlechild

Acta Crystallogr D Struct Biol· April 2018

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