Publications by authors named "Jennifer Meagher"

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Discovery of AK-1690: A Potent and Highly Selective STAT6 PROTAC Degrader.
Atsunori Kaneshige, Yiqing Yang, Longchuan Bai, Mi Wang, Renqi Xu, Jennifer L Meagher

J Med Chem· March 2025

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Discovery of High-Affinity SMARCA2/4 Bromodomain Ligands and Development of Potent and Exceptionally Selective SMARCA2 PROTAC Degraders.
Lingying Leng, Wenbin Tu, Lin Yang, Liyue Huang, Mi Wang, Jennifer L Meagher

J Med Chem· January 2025

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Discovery of SMD-3236: A Potent, Highly Selective and Efficacious SMARCA2 Degrader for the Treatment of SMARC4-Deficient Human Cancers.
Lin Yang, Wenbin Tu, Lingying Leng, Liyue Huang, Wei Jiang, Jennifer L Meagher

J Med Chem· January 2025

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Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E Activity in Cancer.
Emilio L Cárdenas, Rachel L O'Rourke, Arya Menon, Gabriela Vega-Hernández, Jennifer Meagher

ACS Med Chem Lett· January 2025

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A minimal complex of KHNYN and zinc-finger antiviral protein binds and degrades single-stranded RNA.
Zoe C Yeoh, Jennifer L Meagher, Chia-Yu Kang, Paul D Bieniasz, Janet L Smith

Proc Natl Acad Sci U S A· December 2024

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Functional anatomy of zinc finger antiviral protein complexes.
Jennifer A Bohn, Jennifer L Meagher, Matthew A Takata, Daniel Gonçalves-Carneiro, Zoe C Yeoh

Nat Commun· December 2024

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Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
Renqi Xu, Haibin Zhou, Longchuan Bai, Donna McEachern, Dimin Wu, Jennifer L Meagher

J Med Chem· November 2024

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Second-Generation Cap Analogue Prodrugs for Targeting Aberrant Eukaryotic Translation Initiation Factor 4E (eIF4E) Activity in Drug-Resistant Melanoma.
Emilio L Cárdenas, Rachel L O'Rourke, Arya Menon, Gabriela Vega-Hernández, Jennifer Meagher

bioRxiv· September 2024

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Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.
Emilio L Cárdenas, Rachel L O'Rourke, Arya Menon, Jennifer Meagher, Jeanne Stuckey

J Med Chem· August 2023

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A selective small-molecule STAT5 PROTAC degrader capable of achieving tumor regression in vivo.
Atsunori Kaneshige, Longchuan Bai, Mi Wang, Donna McEachern, Jennifer L Meagher

Nat Chem Biol· June 2023

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Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.
Emilio L Cárdenas, Rachel L O'Rourke, Arya Menon, Jennifer Meagher, Jeanne Stuckey

bioRxiv· May 2023

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Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity in Acute Myeloid Leukemia.
Atsunori Kaneshige, Longchuan Bai, Mi Wang, Donna McEachern, Jennifer L Meagher

J Med Chem· February 2023

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A structure-based mechanism for displacement of the HEXIM adapter from 7SK small nuclear RNA.
Vincent V Pham, Michael Gao, Jennifer L Meagher, Janet L Smith, Victoria M D'Souza

Commun Biol· August 2022

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SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression.
Haibin Zhou, Longchuan Bai, Renqi Xu, Donna McEachern, Krishnapriya Chinnaswamy, Jennifer L Meagher

ACS Med Chem Lett· June 2021

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Lipid-based vaccine nanoparticles for induction of humoral immune responses against HIV-1 and SARS-CoV-2.
Kyung Soo Park, Joseph D Bazzill, Sejin Son, Jutaek Nam, Seung Won Shin, Jennifer L Meagher

J Control Release· February 2021

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Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
Evelyn M Covés-Datson, Steven R King, Maureen Legendre, Michael D Swanson, Auroni Gupta, Jennifer L Meagher

Sci Rep· January 2021

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Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins.
Karson J Kump, Lei Miao, Ahmed S A Mady, Nurul H Ansari, Uttar K Shrestha, Jennifer L Meagher

J Med Chem· March 2020

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Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein.
Haibin Zhou, Longchuan Bai, Renqi Xu, Yujun Zhao, Jianyong Chen, Jennifer L Meagher

J Med Chem· December 2019

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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo.
Longchuan Bai, Haibin Zhou, Renqi Xu, Yujun Zhao, Krishnapriya Chinnaswamy, Jennifer L Meagher

Cancer Cell· November 2019

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Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences.
Jennifer L Meagher, Matthew Takata, Daniel Gonçalves-Carneiro, Sarah C Keane, Antoine Rebendenne

Proc Natl Acad Sci U S A· November 2019

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Clarifying the Copper Coordination Environment in a de Novo Designed Red Copper Protein.
Karl J Koebke, Leela Ruckthong, Jennifer L Meagher, Emilie Mathieu, Jill Harland

Inorg Chem· October 2018

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HIV-1 Tat interactions with cellular 7SK and viral TAR RNAs identifies dual structural mimicry.
Vincent V Pham, Carolina Salguero, Shamsun Nahar Khan, Jennifer L Meagher, W Clay Brown

Nat Commun· October 2018

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Differential Conformational Dynamics Encoded by the Linker between Quasi RNA Recognition Motifs of Heterogeneous Nuclear Ribonucleoprotein H.
Srinivasa R Penumutchu, Liang-Yuan Chiu, Jennifer L Meagher, Alexandar L Hansen, Jeanne A Stuckey

J Am Chem Soc· September 2018

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Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression.
Chong Qin, Yang Hu, Bing Zhou, Ester Fernandez-Salas, Chao-Yie Yang, Jennifer Meagher

J Med Chem· August 2018

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Structure-Based Discovery of CF53 as a Potent and Orally Bioavailable Bromodomain and Extra-Terminal (BET) Bromodomain Inhibitor.
Yujun Zhao, Bing Zhou, Longchuan Bai, Liu Liu, Chao-Yie Yang, Jennifer L Meagher

J Med Chem· July 2018

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