Publications by authors named "Jennifer Treiberg"

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Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif.
Stephane Perreault, Fatima Arjmand, Jayaraman Chandrasekhar, Jia Hao, Kathleen S Keegan, Jennifer Treiberg

ACS Med Chem Lett· June 2020

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Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor.
Jayaraman Chandrasekhar, Ryan Dick, Joshua Van Veldhuizen, David Koditek, Eve-Irene Lepist, Jennifer Treiberg

J Med Chem· August 2018

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Nonantibiotic macrolides restore airway macrophage phagocytic function with potential anti-inflammatory effects in chronic lung diseases.
Sandra Hodge, Hai B Tran, Rhys Hamon, Eugene Roscioli, Greg Hodge, Jennifer Treiberg

Am J Physiol Lung Cell Mol Physiol· May 2017

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Discovery of a Phosphoinositide 3-Kinase (PI3K) β/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kβ Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.
Stephane Perreault, Jayaraman Chandrasekhar, Zhi-Hua Cui, Jerry Evarts, Jia Hao, Jennifer Treiberg

J Med Chem· February 2017

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Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.
Leena Patel, Jayaraman Chandrasekhar, Jerry Evarts, Kristen Forseth, Aaron C Haran, Jennifer Treiberg

J Med Chem· October 2016

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2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
Leena Patel, Jayaraman Chandrasekhar, Jerry Evarts, Aaron C Haran, Carmen Ip, Jennifer Treiberg

J Med Chem· April 2016

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A novel highly stereoselective synthesis of 2,3-disubstituted 3H-quinazoline-4-one derivatives.
Paul Zhichkin, Edward Kesicki, Jennifer Treiberg, Lisa Bourdon, Matthew Ronsheim

Org Lett· March 2007

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A specific antagonist of the p110delta catalytic component of phosphatidylinositol 3'-kinase, IC486068, enhances radiation-induced tumor vascular destruction.
Ling Geng, Jiahuai Tan, Eric Himmelfarb, Aaron Schueneman, Ken Niermann, Jennifer Treiberg

Cancer Res· July 2004

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