Publications by authors named "Jennifer Trowbridge"

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Functional Equivalence of Gamma- and X-Ray Irradiation for Long-Term Hematopoietic and AML Transplant Outcomes in Mice.
Shawn David, Griffin J Nye, Ewelina Bolcun-Filas, Jennifer J Trowbridge, Kira A Young

bioRxiv· December 2025

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Inflammatory stromal and T cells mediate human bone marrow niche remodeling in clonal hematopoiesis and myelodysplasia.
Karin D Prummel, Kevin Woods, Maksim Kholmatov, Eric C Schmitt, Evi P Vlachou, Jennifer J Trowbridge

Nat Commun· November 2025

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An Inflammatory and Quiescent HSC Subpopulation Expands with Age in Humans.
Ksenia R Safina, Dylan A Kotliar, Michelle Curtis, Jonathan D Good, Chen Weng, Jennifer Trowbridge

bioRxiv· September 2025

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Plot twist: TET2 clones save the brain.
Maria A Telpoukhovskaia, Jennifer J Trowbridge

Cell Stem Cell· August 2025

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Metallothionein 1 mediates growth and survival of -mutant acute myeloid leukemia.
Patricia A Colom Díaz, Jayna J Mistry, Kira A Young, Chih-Hsing Chou, Nathan Boyer, Jennifer J Trowbridge

Haematologica· August 2025

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Clonal hematopoiesis in myeloid malignancies and solid tumors.
Xiurong Cai, Robert L Bowman, Jennifer J Trowbridge

Nat Cancer· July 2025

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Metformin reduces the competitive advantage of Dnmt3a HSPCs.
Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Jennifer J Trowbridge

Nature· June 2025

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TET2-Mutant Clonal Hematopoiesis Promotes Heart Failure With Preserved Ejection Fraction.
Ambarish Pandey, Toby Thomas, Yuanyuan Ji, Benjamin Kroger, Peter Carlsgaard, Jennifer J Trowbridge

Circulation· June 2025

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Elevated mitochondrial membrane potential is a therapeutic vulnerability in Dnmt3a-mutant clonal hematopoiesis.
Kira A Young, Mohsen Hosseini, Jayna J Mistry, Claudia Morganti, Taylor S Mills, Jennifer J Trowbridge

Nat Commun· April 2025

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In vivo models of subclonal oncogenesis and dependency in hematopoietic malignancy.
Robert L Bowman, Andrew J Dunbar, Tanmay Mishra, Wenbin Xiao, Michael R Waarts, Jennifer J Trowbridge

Cancer Cell· November 2024

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Inflammatory Mesenchymal Stromal Cells and IFN-responsive T cells are key mediators of human bone marrow niche remodeling in CHIP and MDS.
Karin D Prummel, Kevin Woods, Maksim Kholmatov, Eric C Schmitt, Evi P Vlachou, Jennifer J Trowbridge

bioRxiv· November 2024

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Oncostatin M receptor-dependent signaling assessed by RNA sequencing in mouse hematopoietic stem cells.
Logan S Schwartz, Ruth L Saxl, Tim Stearns, Maria Telpoukhovskaia, Jennifer J Trowbridge

Sci Data· September 2024

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Variation in mesenchymal KITL/SCF and IGF1 expression in middle age underlies steady-state hematopoietic stem cell aging.
Kira A Young, Maria A Telpoukhovskaia, Johanna Hofmann, Jayna J Mistry, Konstantinos D Kokkaliaris, Jennifer J Trowbridge

Blood· July 2024

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Mesenchymal Stromal Cell Senescence Induced by -Mutant Hematopoietic Cells is a Targetable Mechanism Driving Clonal Hematopoiesis and Initiation of Hematologic Malignancy.
Jayna J Mistry, Kira A Young, Patricia A Colom Díaz, Inés Fernández Maestre, Ross L Levine, Jennifer J Trowbridge

bioRxiv· March 2024

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Transcriptional and functional consequences of Oncostatin M signaling on young Dnmt3a-mutant hematopoietic stem cells.
Logan S Schwartz, Kira A Young, Timothy M Stearns, Nathan Boyer, Kristina D Mujica, Jennifer J Trowbridge

Exp Hematol· February 2024

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Metformin reduces the clonal fitness of hematopoietic stem and progenitor cells by reversing their aberrant metabolic and epigenetic state.
Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Jennifer J Trowbridge

Res Sq· February 2024

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Author Correction: Clonal hematopoiesis, aging and Alzheimer's disease.
Pablo Sánchez Vela, Jennifer J Trowbridge, Ross L Levine

Nat Med· January 2024

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New insight into the causes, consequences, and correction of hematopoietic stem cell aging.
Els Mansell, Dawn S Lin, Stephen J Loughran, Michael D Milsom, Jennifer J Trowbridge

Exp Hematol· November 2023

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Characterization of an Conditional Knockout Mouse Model.
Logan S Schwartz, Ruth L Saxl, Tim Stearns, Jennifer J Trowbridge

bioRxiv· November 2023

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Hematopoietic stem cell aging and leukemia transformation.
Patricia A Colom Díaz, Jayna J Mistry, Jennifer J Trowbridge

Blood· August 2023

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Clonal hematopoiesis, aging and Alzheimer's disease.
Pablo Sánchez Vela, Jennifer J Trowbridge, Ross L Levine

Nat Med· July 2023

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Oncostatin M is a Master Regulator of an Inflammatory Network in -Mutant Hematopoietic Stem Cells.
Logan S Schwartz, Kira A Young, Timothy M Stearns, Nathan Boyer, Kristina D Mujica, Jennifer J Trowbridge

bioRxiv· July 2023

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Variation in histone configurations correlates with gene expression across nine inbred strains of mice.
Anna L Tyler, Catrina Spruce, Romy Kursawe, Annat Haber, Robyn L Ball, Jennifer J Trowbridge

Genome Res· June 2023

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Challenges and opportunities for modeling aging and cancer.
Olga Anczuków, Susie Airhart, Jeffrey H Chuang, Lisa M Coussens, George A Kuchel, Jennifer J Trowbridge

Cancer Cell· April 2023

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Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis.
Jennifer M SanMiguel, Elizabeth Eudy, Matthew A Loberg, Kira A Young, Jayna J Mistry, Jennifer J Trowbridge

Cancer Discov· December 2022

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