Publications by authors named "Jennitte Stevens"

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Multi-omic characterization of antibody-producing CHO cell lines elucidates metabolic reprogramming and nutrient uptake bottlenecks.
Saratram Gopalakrishnan, William Johnson, Miguel A Valderrama-Gomez, Elcin Icten, Jasmine Tat, Jennitte Stevens

Metab Eng· September 2024

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AMG 509 (Xaluritamig), an Anti-STEAP1 XmAb 2+1 T-cell Redirecting Immune Therapy with Avidity-Dependent Activity against Prostate Cancer.
Olivier Nolan-Stevaux, Cong Li, Lingming Liang, Jinghui Zhan, Juan Estrada, Jennitte Stevens

Cancer Discov· January 2024

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Development of in silico models to predict viscosity and mouse clearance using a comprehensive analytical data set collected on 83 scaffold-consistent monoclonal antibodies.
Marissa Mock, Alex W Jacobitz, Christopher James Langmead, Athena Sudom, Daniel Yoo, Jennitte Stevens

MAbs· November 2023

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A closed, autologous bioprocess optimized for TCR-T cell therapies.
Yijun Liu, Eugenia Zah, Carlos Arbelaez, Haejin Kim, Edwige Gros, Jennitte Stevens

Biotechnol Bioeng· July 2023

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Process development of a SARS-CoV-2 nanoparticle vaccine.
Diandra Martinez-Cano, Rashmi Ravichandran, Huong Le, H Edward Wong, Bharat Jagannathan, Jennitte Stevens

Process Biochem· June 2023

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Considerations for design, manufacture, and delivery for effective and safe T-cell engager therapies.
Tara Arvedson, Julie M Bailis, Thomas Urbig, Jennitte L Stevens

Curr Opin Biotechnol· December 2022

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Microfluidic chip-based single-cell cloning to accelerate biologic production timelines.
Jonathan Diep, Huong Le, Kim Le, Ewelina Zasadzinska, Jasmine Tat, Jennitte Stevens

Biotechnol Prog· November 2021

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AMG 757, a Half-Life Extended, DLL3-Targeted Bispecific T-Cell Engager, Shows High Potency and Sensitivity in Preclinical Models of Small-Cell Lung Cancer.
Michael J Giffin, Keegan Cooke, Edward K Lobenhofer, Juan Estrada, Jinghui Zhan, Jennitte Stevens

Clin Cancer Res· March 2021

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Advancing Biologics Development Programs with Legacy Cell Lines: Advantages and Limitations of Genetic Testing for Addressing Clonality Concerns Prior to Availability of Late Stage Process and Product Consistency Data.
Paul Wu, Taymar Hartman, Louise Almond, Jennitte Stevens, John Thrift

PDA J Pharm Sci Technol· January 2021

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Methods for Estimating the Probability of Clonality in Cell Line Development.
Chun Chen, Kim Le, Huong Le, Kristi Daris, Neil Soice, Jennitte Stevens

Biotechnol J· February 2020

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Assuring Clonality on the Beacon Digital Cell Line Development Platform.
Kim Le, Christopher Tan, Huong Le, Jasmine Tat, Ewelina Zasadzinska, Jennitte Stevens

Biotechnol J· January 2020

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Nanoscale integration of single cell biologics discovery processes using optofluidic manipulation and monitoring.
Marsela Jorgolli, Tanner Nevill, Aaron Winters, Irwin Chen, Su Chong, Jennitte Stevens

Biotechnol Bioeng· September 2019

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Targeting Multiple Myeloma with AMG 424, a Novel Anti-CD38/CD3 Bispecific T-cell-recruiting Antibody Optimized for Cytotoxicity and Cytokine Release.
Christina L Zuch de Zafra, Flordeliza Fajardo, Wendy Zhong, Matthew J Bernett, Umesh S Muchhal, Jennitte Stevens

Clin Cancer Res· July 2019

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Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells.
Christopher S Spahr, Mark E Daris, Kevin C Graham, Brian D Soriano, Jennitte L Stevens

MAbs· June 2019

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A novel mammalian cell line development platform utilizing nanofluidics and optoelectro positioning technology.
Kim Le, Christopher Tan, Shivani Gupta, Trupti Guhan, Hedieh Barkhordarian, Jennitte Stevens

Biotechnol Prog· November 2018

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Characterization of phenotypic and genotypic diversity in subclones derived from a clonal cell line.
Tharmala Tharmalingam, Hedieh Barkhordarian, Nicole Tejeda, Kristi Daris, Sam Yaghmour, Jennitte Stevens

Biotechnol Prog· May 2018

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A biparatopic agonistic antibody that mimics fibroblast growth factor 21 ligand activity.
Sally Yu Shi, Ya-Wen Lu, Zhi Liu, Jennitte Stevens, Christopher M Murawsky

J Biol Chem· April 2018

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Accelerating patient access to novel biologics using stable pool-derived product for non-clinical studies and single clone-derived product for clinical studies.
Trent P Munro, Kim Le, Huong Le, Li Zhang, Jennitte Stevens

Biotechnol Prog· November 2017

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Impact of antibody subclass and disulfide isoform differences on the biological activity of CD200R and βklotho agonist antibodies.
Ognjen Grujic, Jennitte Stevens, Robert Y-T Chou, Jennifer V Weiszmann, Laura Sekirov

Biochem Biophys Res Commun· May 2017

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A bispecific antibody targeting sclerostin and DKK-1 promotes bone mass accrual and fracture repair.
Monica Florio, Kannan Gunasekaran, Marina Stolina, Xiaodong Li, Ling Liu, Jennitte Stevens

Nat Commun· May 2016

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Uncovering methods for the prevention of protein aggregation and improvement of product quality in a transient expression system.
Bram Estes, Yueh-Rong Hsu, Lei-Ting Tam, Jackie Sheng, Jennitte Stevens

Biotechnol Prog· December 2015

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Recombinant human lecithin-cholesterol acyltransferase Fc fusion: analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region.
Chris Spahr, Justin J Kim, Sihong Deng, Paul Kodama, Zhen Xia, Jennitte Stevens

Protein Sci· December 2013

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FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/β-Klotho bispecific protein.
Richard Smith, Amy Duguay, Alice Bakker, Peng Li, Jennifer Weiszmann, Jennitte Stevens

PLoS One· November 2013

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Inhibition of WISE preserves renal allograft function.
Xueming Qian, Xiaodong Yuan, Steven Vonderfecht, Xupeng Ge, Jae Lee, Jennitte L Stevens

J Am Soc Nephrol· January 2013

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Treating diabetes and obesity with an FGF21-mimetic antibody activating the βKlotho/FGFR1c receptor complex.
Ian N Foltz, Sylvia Hu, Chadwick King, Xinle Wu, Chaofeng Yang, Jennitte Stevens

Sci Transl Med· November 2012

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