Publications by authors named "Jeremy Cheadle"

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Comparison between germline and somatic loss-of-function mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis.
Claire Palles, Luke Freeman-Mills, Edward Arbe-Barnes, Nathalie Feeley, Laura Chegwidden, Jeremy Cheadle

Gut· December 2025

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Relationship between inherited genetic variation and survival from colorectal cancer stratified by tumour location.
Christopher Wills, Katie Watts, Amy Houseman, Timothy S Maughan, David Fisher, Jeremy P Cheadle

Sci Rep· January 2025

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Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
Zhishan Chen, Xingyi Guo, Ran Tao, Jeroen R Huyghe, Philip J Law, Jeremy P Cheadle

Nat Commun· April 2024

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Pan-Cancer Interrogation of Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors.
Channing J Paller, Hanna Tukachinsky, Alexandra Maertens, Brennan Decker, Julian R Sampson, Jeremy P Cheadle

JCO Precis Oncol· February 2024

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Relationship between 233 colorectal cancer risk loci and survival in 1926 patients with advanced disease.
Christopher Wills, Amy Houseman, Katie Watts, Timothy S Maughan, David Fisher, Jeremy P Cheadle

BJC Rep· June 2023

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Germline variation in RASAL2 may predict survival in patients with RAS-activated colorectal cancer.
Christopher Wills, Katie Watts, Timothy S Maughan, David Fisher, Nada A Al-Tassan, Jeremy P Cheadle

Genes Chromosomes Cancer· June 2023

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Author Correction: Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Jeremy Cheadle

Nat Genet· March 2023

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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.
Ceres Fernandez-Rozadilla, Maria Timofeeva, Zhishan Chen, Philip Law, Minta Thomas, Jeremy Cheadle

Nat Genet· January 2023

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Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand-foot syndrome.
Katie Watts, Christopher Wills, Ayman Madi, Claire Palles, Timothy S Maughan, Jeremy P Cheadle

Int J Cancer· September 2022

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Germline MBD4 deficiency causes a multi-tumor predisposition syndrome.
Claire Palles, Hannah D West, Edward Chew, Sara Galavotti, Christoffer Flensburg, Jeremy P Cheadle

Am J Hum Genet· May 2022

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A genome-wide search for determinants of survival in 1926 patients with advanced colorectal cancer with follow-up in over 22,000 patients.
Christopher Wills, Yazhou He, Matthew G Summers, Yi Lin, Amanda I Phipps, Jeremy P Cheadle

Eur J Cancer· December 2021

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Genome-wide association studies of toxicity to oxaliplatin and fluoropyrimidine chemotherapy with or without cetuximab in 1800 patients with advanced colorectal cancer.
Katie Watts, Christopher Wills, Ayman Madi, Claire Palles, Timothy S Maughan, Jeremy P Cheadle

Int J Cancer· November 2021

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Lack of an association between gallstone disease and bilirubin levels with risk of colorectal cancer: a Mendelian randomisation analysis.
Richard Culliford, Alex J Cornish, Philip J Law, Susan M Farrington, Kimmo Palin, Jeremy P Cheadle

Br J Cancer· March 2021

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Modifiable pathways for colorectal cancer: a mendelian randomisation analysis.
Alex J Cornish, Philip J Law, Maria Timofeeva, Kimmo Palin, Susan M Farrington, Jeremy P Cheadle

Lancet Gastroenterol Hepatol· January 2020

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Comprehensive analysis of colorectal cancer-risk loci and survival outcome: A prognostic role for CDH1 variants.
Matthew G Summers, Timothy S Maughan, Richard Kaplan, Philip J Law, Richard S Houlston, Jeremy P Cheadle

Eur J Cancer· January 2020

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Pattern Recognition Receptor Polymorphisms as Predictors of Oxaliplatin Benefit in Colorectal Cancer.
Victoria Gray, Sarah Briggs, Claire Palles, Emma Jaeger, Timothy Iveson, Jeremy P Cheadle

J Natl Cancer Inst· August 2019

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Association analyses identify 31 new risk loci for colorectal cancer susceptibility.
Philip J Law, Maria Timofeeva, Ceres Fernandez-Rozadilla, Peter Broderick, James Studd, Jeremy P Cheadle

Nat Commun· May 2019

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Role for Nucleotide Excision Repair Gene Variants in Oxaliplatin-Induced Peripheral Neuropathy.
Hannah West, Michelle Coffey, Michael J Wagner, Howard L McLeod, James P Colley, Jeremy P Cheadle

JCO Precis Oncol· November 2018

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Pharmacogenetic analyses of 2183 patients with advanced colorectal cancer; potential role for common dihydropyrimidine dehydrogenase variants in toxicity to chemotherapy.
Ayman Madi, David Fisher, Timothy S Maughan, James P Colley, Angela M Meade, Jeremy P Cheadle

Eur J Cancer· October 2018

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Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci.
Tomas Tanskanen, Linda van den Berg, Niko Välimäki, Mervi Aavikko, Eivind Ness-Jensen, Jeremy P Cheadle

Int J Cancer· February 2018

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Pro-inflammatory fatty acid profile and colorectal cancer risk: A Mendelian randomisation analysis.
Sebastian May-Wilson, Amit Sud, Philip J Law, Kimmo Palin, Sari Tuupanen, Jeremy P Cheadle

Eur J Cancer· October 2017

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Comprehensive pharmacogenetic profiling of the epidermal growth factor receptor pathway for biomarkers of response to, and toxicity from, cetuximab.
Ayman Madi, David Fisher, Timothy S Maughan, James P Colley, Angela M Meade, Jeremy P Cheadle

J Med Genet· August 2017

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and Locus-Specific Variants Have Different Outcomes on Survival to Colorectal Cancer.
Matthew G Summers, Christopher G Smith, Timothy S Maughan, Richard Kaplan, Valentina Escott-Price, Jeremy P Cheadle

Clin Cancer Res· June 2017

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Mendelian randomisation implicates hyperlipidaemia as a risk factor for colorectal cancer.
Henry Rodriguez-Broadbent, Philip J Law, Amit Sud, Kimmo Palin, Sari Tuupanen, Jeremy P Cheadle

Int J Cancer· June 2017

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Variation at 2q35 (PNKD and TMBIM1) influences colorectal cancer risk and identifies a pleiotropic effect with inflammatory bowel disease.
Giulia Orlando, Philip J Law, Kimmo Palin, Sari Tuupanen, Alexandra Gylfe, Jeremy P Cheadle

Hum Mol Genet· June 2016

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