Publications by authors named "Jeremy Clemens"

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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as CCR2 antagonists.
Maris Vilums, Annelien J M Zweemer, Farhana Barmare, Anouk M F van der Gracht, Dave C T Bleeker, Jeremy Clemens

Eur J Med Chem· March 2015

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Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors.
Timothy Neubert, Mehdi Numa, Justin Ernst, Jeremy Clemens, Paul Krenitsky

Bioorg Med Chem Lett· March 2015

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Strategies for the modulation of phase II metabolism in a series of PKCε inhibitors.
Jeremy J Clemens, Timothy Coon, Brett B Busch, Juliana L Asgian, Sarah Hudson

Bioorg Med Chem Lett· August 2014

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Structure-kinetic relationships--an overlooked parameter in hit-to-lead optimization: a case of cyclopentylamines as chemokine receptor 2 antagonists.
Maris Vilums, Annelien J M Zweemer, Zhiyi Yu, Henk de Vries, Julia M Hillger, Jeremy Clemens

J Med Chem· October 2013

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Diastereoselective one-pot Knoevenagel condensation/Corey-Chaykovsky cyclopropanation.
Jeremy J Clemens, Juliana L Asgian, Brett B Busch, Timothy Coon, Justin Ernst

J Org Chem· January 2013

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The structure of the Staphylococcus aureus sortase-substrate complex reveals how the universally conserved LPXTG sorting signal is recognized.
Nuttee Suree, Chu Kong Liew, Valerie A Villareal, William Thieu, Evgeny A Fadeev, Jeremy J Clemens

J Biol Chem· September 2009

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Staphylococcus aureus Sortase A transpeptidase. Calcium promotes sorting signal binding by altering the mobility and structure of an active site loop.
Mandar T Naik, Nuttee Suree, Udayar Ilangovan, Chu Kong Liew, William Thieu, Jeremy J Clemens

J Biol Chem· January 2006

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Synthesis of (2R,3S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases.
Michael E Jung, Jeremy J Clemens, Nuttee Suree, Chu Kong Liew, Rosemarie Pilpa

Bioorg Med Chem Lett· November 2005

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Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors.
Frank W Foss, Jeremy J Clemens, Michael D Davis, Ashley H Snyder, Molly A Zigler

Bioorg Med Chem Lett· October 2005

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Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists.
Jeremy J Clemens, Michael D Davis, Kevin R Lynch, Timothy L Macdonald

Bioorg Med Chem Lett· August 2005

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Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.
David T Bolick, Suseela Srinivasan, Kyu W Kim, Melissa E Hatley, Jeremy J Clemens

Arterioscler Thromb Vasc Biol· May 2005

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Sphingosine 1-phosphate analogs as receptor antagonists.
Michael D Davis, Jeremy J Clemens, Timothy L Macdonald, Kevin R Lynch

J Biol Chem· March 2005

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Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists.
Jeremy J Clemens, Michael D Davis, Kevin R Lynch, Timothy L Macdonald

Bioorg Med Chem Lett· October 2004

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Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists.
Jeremy J Clemens, Michael D Davis, Kevin R Lynch, Timothy L Macdonald

Bioorg Med Chem Lett· October 2003

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