Publications by authors named "Jeremy S Duffield"

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3'-end ligation sequencing is a sensitive method to detect DNA nicks at potential sites of off-target activity induced by prime editors.
Jacob Stewart-Ornstein, Matthew J Irby, Marina K Lilieholm, Dylan Laprise, Maria D Collier, Jeremy S Duffield

Genome Res· September 2025

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MANF stimulates autophagy and restores mitochondrial homeostasis to treat autosomal dominant tubulointerstitial kidney disease in mice.
Yeawon Kim, Chuang Li, Chenjian Gu, Yili Fang, Eric Tycksen, Jeremy S Duffield

Nat Commun· October 2023

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MANF stimulates autophagy and restores mitochondrial homeostasis to treat toxic proteinopathy.
Yeawon Kim, Chuang Li, Chenjian Gu, Eric Tycksen, Anuradhika Puri, Jeremy S Duffield

bioRxiv· January 2023

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The glomerular filtration barrier: a structural target for novel kidney therapies.
Ilse S Daehn, Jeremy S Duffield

Nat Rev Drug Discov· October 2021

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Ultrabright plasmonic fluor nanolabel-enabled detection of a urinary ER stress biomarker in autosomal dominant tubulointerstitial kidney disease.
Yeawon Kim, Zheyu Wang, Chuang Li, Kendrah Kidd, Yixuan Wang, Jeremy S Duffield

Am J Physiol Renal Physiol· August 2021

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Deletion of the Mitochondrial Complex-IV Cofactor Heme A:Farnesyltransferase Causes Focal Segmental Glomerulosclerosis and Interferon Response.
Jea-Hyun Baek, Ivan G Gomez, Yukihiro Wada, Allie Roach, Don Mahad, Jeremy S Duffield

Am J Pathol· December 2018

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Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney.
Amrutesh S Puranik, Irina A Leaf, Mark A Jensen, Ahmad F Hedayat, Ahmad Saad, Jeremy S Duffield

Sci Rep· September 2018

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Interleukin-1 Activates a MYC-Dependent Metabolic Switch in Kidney Stromal Cells Necessary for Progressive Tubulointerstitial Fibrosis.
Dario R Lemos, Michael McMurdo, Gamze Karaca, Julia Wilflingseder, Irina A Leaf, Jeremy S Duffield

J Am Soc Nephrol· June 2018

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Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies.
Dario R Lemos, Jeremy S Duffield

Sci Transl Med· January 2018

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Uromodulin p.Cys147Trp mutation drives kidney disease by activating ER stress and apoptosis.
Bryce G Johnson, Lan T Dang, Graham Marsh, Allie M Roach, Zebulon G Levine, Jeremy S Duffield

J Clin Invest· November 2017

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Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury.
Lan T H Dang, Takahide Aburatani, Graham A Marsh, Bryce G Johnson, Stella Alimperti, Jeremy S Duffield

Biomaterials· October 2017

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Inhibition of v5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury.
Amy McCurley, Stella Alimperti, Silvia B Campos-Bilderback, Ruben M Sandoval, Jenna E Calvino, Jeremy S Duffield

J Am Soc Nephrol· June 2017

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Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor-Related Protein 6.
Bryce G Johnson, Shuyu Ren, Gamze Karaca, Ivan G Gomez, Cécile Fligny, Jeremy S Duffield

J Am Soc Nephrol· June 2017

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Lung pericyte-like cells are functional interstitial immune sentinel cells.
Chi F Hung, Kristen L Mittelsteadt, Rena Brauer, Bonnie L McKinney, Teal S Hallstrand, Jeremy S Duffield

Am J Physiol Lung Cell Mol Physiol· April 2017

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Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor.
Norihiko Sakai, Jerold Chun, Jeremy S Duffield, David Lagares, Takashi Wada

Kidney Int· March 2017

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Pericytes and immune cells contribute to complement activation in tubulointerstitial fibrosis.
Sandhya Xavier, Ranjit K Sahu, Susan G Landes, Jing Yu, Ronald P Taylor, Jeremy S Duffield

Am J Physiol Renal Physiol· March 2017

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Serelaxin as a potential treatment for renal dysfunction in cirrhosis: Preclinical evaluation and results of a randomized phase 2 trial.
Victoria K Snowdon, Neil J Lachlan, Anna M Hoy, Patrick W F Hadoke, Scott I Semple, Jeremy S Duffield

PLoS Med· February 2017

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Pericyte MyD88 and IRAK4 control inflammatory and fibrotic responses to tissue injury.
Irina A Leaf, Shunsaku Nakagawa, Bryce G Johnson, Jin Joo Cha, Kristen Mittelsteadt, Jeremy S Duffield

J Clin Invest· January 2017

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What can target kidney fibrosis?
Irina A Leaf, Jeremy S Duffield

Nephrol Dial Transplant· January 2017

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TWEAK-Fn14 Signaling Activates Myofibroblasts to Drive Progression of Fibrotic Kidney Disease.
Ivan G Gomez, Allie M Roach, Naoki Nakagawa, Aldo Amatucci, Bryce G Johnson, Jeremy S Duffield

J Am Soc Nephrol· December 2016

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Maintenance of vascular integrity by pericytes is essential for normal kidney function.
Dario R Lemos, Graham Marsh, Angela Huang, Gabriela Campanholle, Takahide Aburatani, Jeremy S Duffield

Am J Physiol Renal Physiol· December 2016

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Beyond EMT: Epithelial STAT3 as a Central Regulator of Fibrogenesis.
Jeremy S Duffield

J Am Soc Nephrol· December 2016

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PDGFRα signalling promotes fibrogenic responses in collagen-producing cells in Duchenne muscular dystrophy.
Nicholas Ieronimakis, Aislinn Hays, Amalthiya Prasad, Kajohnkiart Janebodin, Jeremy S Duffield

J Pathol· December 2016

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Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease.
Naoki Nakagawa, Luke Barron, Ivan G Gomez, Bryce G Johnson, Allie M Roach, Jeremy S Duffield

JCI Insight· December 2016

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Lung Pericytes and Resident Fibroblasts: Busy Multitaskers.
Luke Barron, Sina A Gharib, Jeremy S Duffield

Am J Pathol· October 2016

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