Publications by authors named "Jesse Wiley"

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Human microglia show unique transcriptional changes in Alzheimer's disease.
Katherine E Prater, Kevin J Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L Smith, Kenneth L Chiou, Laura Heath, Shannon E Rose, Jesse Wiley

July 2023

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Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets.
Gregory A Cary, Qianjin Li, Jesse C Wiley, Carolyn A Paisie, Yuhong Du

Alzheimers Dement· December 2025

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PAK1 inhibitor NVS-PAK1-1 preserves dendritic spines in amyloid/tau exposed neurons and 5xFAD mice.
Tao Yang, Hasi Huhe, Sean-Paul Williams, Sukhneet Kaur, Yeonglong Albert Ay, Jesse Wiley

Alzheimers Dement· December 2025

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Integrated phenotypic and proteomic screening identifies top-tier Alzheimer's disease therapeutic targets.
Gregory A Cary, Qianjin Li, Jesse C Wiley, Carolyn A Paisie, Yuhong Du

bioRxiv· October 2025

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Mapping cross-domain drivers of Alzheimer's disease risk through integrated network analysis.
Gregory A Cary, Stephen Keegan, Jesse C Wiley, Jake Gockley, Frank M Longo

bioRxiv· October 2025

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Mitochondrial complex I deficiency induces Alzheimer's disease-like signatures that are reversible by targeted therapy.
Huanyao Gao, Kate Jensen, Jarred Nesbitt, Mark Ostroot, Gregory A Cary, Jesse Wiley

Alzheimers Dement· August 2025

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Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains.
Gregory A Cary, Jesse C Wiley, Jake Gockley, Stephen Keegan, Sai Sruthi Amirtha Ganesh

Alzheimers Dement (N Y)· April 2024

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New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop.
Maria A Telpoukhovskaia, Thomas J Murdy, Olivia J Marola, Kevin Charland, Michael MacLean, Jesse Wiley

Alzheimers Dement (N Y)· March 2024

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, Jesse C Wiley

PLoS One· February 2024

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Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM.
Frances M Bashore, Vittorio L Katis, Yuhong Du, Arunima Sikdar, Dongxue Wang, Jesse C Wiley

bioRxiv· July 2023

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Multi-tissue neocortical transcriptome-wide association study implicates 8 genes across 6 genomic loci in Alzheimer's disease.
Jake Gockley, Kelsey S Montgomery, William L Poehlman, Jesse C Wiley, Yue Liu

Genome Med· May 2021

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Optimizing Parkinson's disease diagnosis: the role of a dual nuclear imaging algorithm.
J William Langston, Jesse C Wiley, Michele Tagliati

NPJ Parkinsons Dis· February 2018

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Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling.
James S Meabon, Rian de Laat, Katsuaki Ieguchi, Dmitry Serbzhinsky, Mark P Hudson, Jesse C Wiley

Mol Cell Neurosci· January 2016

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LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.
James S Meabon, Rian De Laat, Katsuaki Ieguchi, Jesse C Wiley, Mark P Hudson

J Biol Chem· April 2015

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LINGO-1 promotes lysosomal degradation of amyloid-β protein precursor.
Rian de Laat, James S Meabon, Jesse C Wiley, Mark P Hudson, Thomas J Montine

Pathobiol Aging Age Relat Dis· March 2015

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A novel radial water tread maze tracks age-related cognitive decline in mice.
Christina Pettan-Brewer, Dylan V Touch, Jesse C Wiley, Heather C Hopkins, Peter S Rabinovitch

Pathobiol Aging Age Relat Dis· October 2013

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Identification of putative immunologic targets for colon cancer prevention based on conserved gene upregulation from preinvasive to malignant lesions.
Elizabeth K Broussard, Rachel Kim, Jesse C Wiley, Juan Pablo Marquez, James E Annis

Cancer Prev Res (Phila)· July 2013

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Determining true HER2 gene status in breast cancers with polysomy by using alternative chromosome 17 reference genes: implications for anti-HER2 targeted therapy.
Chun Hing Tse, Harry C Hwang, Lynn C Goldstein, Patricia L Kandalaft, Jesse C Wiley

J Clin Oncol· November 2011

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Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice.
Jesse C Wiley, Christina Pettan-Brewer, Warren C Ladiges

Aging Cell· June 2011

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Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine release.
Suman Jayadev, Amanda Case, Alison J Eastman, Huy Nguyen, Julia Pollak, Jesse C Wiley

PLoS One· December 2010

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Trk activation in the secretory pathway promotes Golgi fragmentation.
Leslayann C Schecterson, Mark P Hudson, Mabel Ko, Polyxeni Philippidou, Wendy Akmentin, Jesse Wiley

Mol Cell Neurosci· April 2010

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Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells.
Jesse C Wiley, James S Meabon, Harald Frankowski, Elise A Smith, Leslayann C Schecterson

PLoS One· February 2010

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Chalkboard: ontology-based pathway modeling and qualitative inference of disease mechanisms.
Daniel L Cook, Jesse C Wiley, John H Gennari

Pac Symp Biocomput· December 2007

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Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.
Jesse C Wiley, Elise A Smith, Mark P Hudson, Warren C Ladiges, Mark Bothwell

J Biol Chem· November 2007

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Comparative Mouse Genomics Centers Consortium: the Mouse Genotype Database.
Jesse C Wiley, Manjula Prattipati, Ching-Ping Lin, Warren Ladiges

Mutat Res· March 2006

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