PubHawk
July 2023 PMID 37248328

Human microglia show unique transcriptional changes in Alzheimer's disease.

Katherine E Prater, Kevin J Green, Sainath Mamde, Wei Sun, Alexandra Cochoit, Carole L Smith, Kenneth L Chiou, Laura Heath, Shannon E Rose, Jesse Wiley, C Dirk Keene, Ronald Y Kwon, Noah Snyder-Mackler, Elizabeth E Blue, Benjamin Logsdon

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Mentions

115
Peak: 63 in May 2023
across 5 sources since May 2023

Extended reach

281,562
potential audience

Total likes

309

Video views

450

Mentions per month

May 2023 – Nov 2024

Where it's discussed

  • X / Twitter80 posts
  • News28 articles
  • Blogs4 articles
  • Facebook2 posts
  • YouTube1 videos

AI synopsis

What people are saying

Several discussions revolve around the key insights of the study, with phrases like 'unique transcriptional changes' and inquiries such as 'Is this going to be disease specific rather than disease associated?' reflecting deep engagement. The tone is predominantly inquisitive and supportive, signaling a grasp of the study's complexities and potential applications in therapeutic strategies.

AgreementModerate agreement

The majority of discussions indicate a general support for the findings presented in the publication.

InterestHigh interest

Many contributors express a strong level of curiosity regarding the implications of the research.

EngagementModerate engagement

While some posts show a basic acknowledgment of the study, a few delve into its methodology, reflecting some engagement.

ImpactHigh impact

Many believe that the research could have significant implications for understanding Alzheimer's disease, suggesting a strong perceived impact.

Abstract in brief

  • The study investigates transcriptional changes in human microglia, the brain's immune cells, related to Alzheimer's disease (AD), aiming to understand their role in disease progression.
  • Researchers compared microglia from 12 AD patients and 10 control subjects using advanced RNA sequencing techniques, uncovering both known and new microglial molecular phenotypes.
  • Findings reveal specific microglial phenotypes more common in AD cases, highlighting the complexity and diversity of microglial functions, which could inform potential therapeutic strategies for the disease.
Read the full abstract

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Celeste Karch
@karchlab · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 88 likes · 18 shares · 4,279 followers View post →
Lukas Valihrach
@LukasValihrach · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 76 likes · 19 shares · 3,423 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes in Alzheimer’s disease | Nature Aging https://t.co/4s0uPSfv03

May 30, 2023 · 46 likes · 10 shares · 4,742 followers View post →
Nat Rev Neurology
@NatRevNeurol · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 30, 2023 · 38 likes · 11 shares · 46,420 followers View post →
Agingdoc
@agingdoc1 · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/y03hdvHopL @NatureAging https://t.co/19W5y3gF8Y

May 30, 2023 · 11 likes · 2 shares · 41,345 followers View post →
Agingdoc
@agingdoc1 · X

Human microglia show unique transcriptional changes in Alzheimer's disease https://t.co/y03hdvHopL https://t.co/EoEhBAiWhu

May 31, 2023 · 7 likes · 41,345 followers View post →

All mentions

Roger Blackwell
@rogerablackwell · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/JgpAvG5AdP

Nov 14, 2024 · 2,297 followers View post →
persiancat
@persian40208572 · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

Feb 19, 2024 · 19 shares · 11 followers View post →
aloneandnameless
@anarimafornow · X

RT @TeresaB16548284: https://t.co/jBceYv7G8K Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/365XjU…

Dec 19, 2023 · 1 share · 6,958 followers View post →
Goldie Elaine
@TeresaB16548284 · X

https://t.co/jBceYv7G8K Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/365XjUrC1o

Dec 18, 2023 · 1 share · 1,176 followers View post →
PostX #UniteToFight2024
@TeamPostX · X

RT @MarekSJF: "Human microglia show unique transcriptional changes in Alzheimer’s disease" https://t.co/JQcxfSJ3AU

Aug 29, 2023 · 3 shares · 2,050 followers View post →
Mountain life
@mountainkeep · X

RT @MarekSJF: "Human microglia show unique transcriptional changes in Alzheimer’s disease" https://t.co/JQcxfSJ3AU

Aug 29, 2023 · 3 shares · 925 followers View post →
Dr. Markus Fraczek
@MarekSJF · X

"Human microglia show unique transcriptional changes in Alzheimer’s disease" https://t.co/JQcxfSJ3AU

Aug 28, 2023 · 5 likes · 3 shares · 2,719 followers View post →
Roger Blackwell
@rogerablackwell · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/JgpAvG683n

Aug 26, 2023 · 2,297 followers View post →
Orlando_uy
@Orlando_uy · X

Human microglia show unique transcriptional changes in Alzheimer’s disease. https://t.co/tGglcxTCEx

Aug 22, 2023 · 691 followers View post →
Ariakas Enoreth
@Aenoreth · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/aWsStGnYGf

Aug 10, 2023 · 1,009 followers View post →
SourceControl21
@SourceControl21 · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

Jul 4, 2023 · 11 shares · 862 followers View post →
Tay Lab
@TayLab_CNS · X

RT @ryuta_koyama: Human microglia show unique transcriptional changes in Alzheimer’s disease | Nature Aging https://t.co/vRCFbjaZXe

Jun 1, 2023 · 1 share · 659 followers View post →
STIGMABASE
@stigmabase · X

TW : Human microglia show unique transcriptional changes in Alzheimer’s disease | Nature Aging: ...the Neuropathology Core of the Alzheimer’s Disease Research Center at University of Washington after written informed... https://t.co/jKVS4iI23S https://t.co/jqwGDLa2u1

Jun 1, 2023 · 1,122 followers View post →
Chun-Jie Liu
@chunjie_sam_liu · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

Jun 1, 2023 · 19 shares · 65 followers View post →
Aurora Scrivo
@AuroraScrivo1 · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

Jun 1, 2023 · 11 shares · 186 followers View post →
Ryuta Koyama
@ryuta_koyama · X

Human microglia show unique transcriptional changes in Alzheimer’s disease | Nature Aging https://t.co/vRCFbjaZXe

Jun 1, 2023 · 4 likes · 1 share · 383 followers View post →
priya joseph
@ayirpelle · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

Jun 1, 2023 · 19 shares · 4,891 followers View post →
Alos Diallo
@alos_31 · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 351 followers View post →
Anshul Kundaje (anshulkundaje@bluesky)
@anshulkundaje · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 26,894 followers View post →
Kelvin Hui
@kelvinhui_cira · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 31, 2023 · 11 shares · 184 followers View post →
Alex Tamburino
@AlexTamburino · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 110 followers View post →
Iturria-Medina
@MedinYasser · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 658 followers View post →
Larry Spears
@LarryDSpearsJr · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 708 followers View post →
Lee J. Keller
@leejkeller · X

Human microglia show unique transcriptional changes in Alzheimer’s disease - Nature Aging https://t.co/MNhdSGRM3m

May 31, 2023 · 1,128 followers View post →
Pilar Andrade
@PilarIAndrade · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 172 followers View post →
Jim Johnson, PhD
@JimJohnsonSci · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 12,803 followers View post →
KCON Health News
@KCONHealthNews · X

Human microglia show unique transcriptional changes in Alzheimer’s disease - Nature Aging https://t.co/bawZhPeD6A

May 31, 2023 · 209 followers View post →
Técnico molecular
@TMolecular13 · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 175 followers View post →
Eric Minwei Liu
@EricM_Liu · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 932 followers View post →
Bruno Cabral Braga
@cabral_bb · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 115 followers View post →
ChrisAWalsh
@ChrisAWalsh1 · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 31, 2023 · 11 shares · 1,820 followers View post →
Seungho Oh @seunghooh@genomic.social
@dancewithsun · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 98 followers View post →
Hadley Miller
@HadleyMiller8 · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 1,111 followers View post →
Maksim Nesterenko
@linux_maxima · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 94 followers View post →
Tomasz Grzywa, MD, PhD
@drtomaszgrzywa · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 377 followers View post →
Dr. Brad Reinfeld, MD PhD
@BReinfeld · X

RT @LukasValihrach: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 19 shares · 1,420 followers View post →
Eric Dammer
@EricDammer · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 31, 2023 · 11 shares · 50 followers View post →
Agingdoc
@agingdoc1 · X

Human microglia show unique transcriptional changes in Alzheimer's disease https://t.co/y03hdvHopL https://t.co/EoEhBAiWhu

May 31, 2023 · 7 likes · 41,345 followers View post →
Andrea McBeth
@DreMcBeth · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 31, 2023 · 10 shares · 262 followers View post →
Lukas Valihrach
@LukasValihrach · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/sDQEZbapJy

May 31, 2023 · 76 likes · 19 shares · 3,423 followers View post →
Syed Ali Raza (Ali)
@Ali_SyedRaza · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 31, 2023 · 11 shares · 2,949 followers View post →
MilesJun
@MilesJun2 · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 31, 2023 · 10 shares · 30 followers View post →
Dr. Elizabeth Head
@ElzHead · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 31, 2023 · 18 shares · 3,611 followers View post →
Giovanni Di Liberto
@DiLibertoMD · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 31, 2023 · 11 shares · 1,208 followers View post →
ZZneuroscience
@ZZneuroscience · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 3 followers View post →
Yu Chen
@normacyyyyyy · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 51 followers View post →
Matsukiblade
@matsukiblade · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 2,752 followers View post →
SNZK
@shinopp · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 723 followers View post →
Afrinash
@Afrinashahamad · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 412 followers View post →
Sarah Naguib, PhD
@naguib_sarah · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 1,169 followers View post →
LogarithmicDis
@LogarithmicDis · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 1,014 followers View post →
Lindsay Rizzardi, PhD
@LindsayRizzardi · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 494 followers View post →
Frank Paul Mora
@InTime_49 · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 387 followers View post →
Eunchai Kang
@neural_lab · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 261 followers View post →
Dieter
@Wuhle · X

RT @agingdoc1: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/y03hdvHopL @NatureAging https://t.c…

May 30, 2023 · 2 shares · 477 followers View post →
Cristel 70
@cinziasams · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 2,256 followers View post →
Komolafe John
@JohnnyKomolafe · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 30, 2023 · 11 shares · 329 followers View post →
Sudhir Thakurela/सुधीर ठकुरेला
@sudhirthakurela · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 1,395 followers View post →
simaxiaoer
@Simao70053701 · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 7 followers View post →
Brayan Campos-Salazar
@ABrayanCampos · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 1,630 followers View post →
David A Posner
@DavidPosner13 · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 1,018 followers View post →
Dervis Salih
@DervisSalih1 · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 4,514 followers View post →
Kurt zimmerman
@Zimmermk1986 · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 675 followers View post →
Nicole Lemon
@lemonnl · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 668 followers View post →
Bayar Jaff
@JaffBayar · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 607 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 404 followers View post →
John Lukens
@LukensJohnR · X

RT @karchlab: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 18 shares · 14,051 followers View post →
J. Fernando Bazan @jfernandobazan.bsky.social
@jfernandobazan · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 30, 2023 · 11 shares · 705 followers View post →
Celeste Karch
@karchlab · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/DIP7STRhps

May 30, 2023 · 88 likes · 18 shares · 4,279 followers View post →
Claudia Cantoni
@Clodida · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 483 followers View post →
Waggoner Lab
@LabWaggoner · X

Human microglia show unique transcriptional changes in Alzheimer’s disease @katieeprater https://t.co/CdVJF5iyXW

May 30, 2023 · 11,319 followers View post →
Luis J. Castro-Vega
@LuisJaimeCastr3 · X

RT @Pluchinolab: Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes i…

May 30, 2023 · 10 shares · 658 followers View post →
Pluchino lab - Regenerative Neuroimmunology
@Pluchinolab · X

Is this going to be disease specific rather than disease associated? Human microglia show unique transcriptional changes in Alzheimer’s disease | Nature Aging https://t.co/4s0uPSfv03

May 30, 2023 · 46 likes · 10 shares · 4,742 followers View post →
Bayar Jaff
@JaffBayar · X

RT @agingdoc1: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/y03hdvHopL @NatureAging https://t.c…

May 30, 2023 · 2 shares · 607 followers View post →
Agingdoc
@agingdoc1 · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/y03hdvHopL @NatureAging https://t.co/19W5y3gF8Y

May 30, 2023 · 11 likes · 2 shares · 41,345 followers View post →
Jaunis Estervil, MD.
@JaunisMd · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 30, 2023 · 11 shares · 178 followers View post →
Haass lab
@Haass_Lab · X

RT @NatRevNeurol: Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 30, 2023 · 11 shares · 1,121 followers View post →
Nat Rev Neurology
@NatRevNeurol · X

Human microglia show unique transcriptional changes in Alzheimer’s disease https://t.co/I77B2sJjfi

May 30, 2023 · 38 likes · 11 shares · 46,420 followers View post →
Ageing and Neurodegenerative Diseases
@OAE_AgeNeuDis · X

May 29, 2023 · 4 likes · 442 followers View post →
STIGMABASE
@stigmabase · X

{Fighting Stigma} Human microglia show unique transcriptional changes in Alzheimer's disease - Nature: Microglia, the innate immune cells of the brain, exhibit diverse functions and can influence Alzheimer's disease progression. This study explores ... https://t.co/2HQHmdKULR

May 29, 2023 · 1,122 followers View post →