Publications by authors named "Jessica B Spinelli"

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Distinct S-adenosylmethionine synthases link phosphatidylcholine to mitochondrial function and stress survival.
Athena L Munden, Arjamand Mushtaq, Dominique S Lui, Katherine M Edwards, Daniel P Higgins, Jessica B Spinelli

PLoS Biol· December 2025

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Regenerating liver uses ammonia to support de novo pyrimidine synthesis and cell proliferation.
Berwini B Endaya, Lukáš Kučera, Dan-Diem Thi Le, Jessica B Spinelli, Andrea Brožková

Nat Commun· November 2025

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Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose lipogenesis.
Nikita Bhalerao, Yamini Ogoti, Jessica Peura, Calvin Johnson, Qingbo Chen, Jessica B Spinelli

bioRxiv· August 2025

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Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation.
Rayna Y Magesh, Arshia N Kaur, Faith N Keller, Abdulrazak Frederick, Tenzin Tseyang, Jessica B Spinelli

Genes Dev· June 2025

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Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity.
Tigist Y Tamir, Shreya Chaudhary, Annie X Li, Sonia E Trojan, Cameron T Flower, Jessica B Spinelli

Mol Cell· June 2025

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Protocol to extract and measure ubiquinone and rhodoquinone in murine tissues.
Madison Jerome, Jessica B Spinelli

STAR Protoc· June 2025

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Ergothioneine controls mitochondrial function and exercise performance via direct activation of MPST.
Hans-Georg Sprenger, Melanie J Mittenbühler, Yizhi Sun, Jonathan G Van Vranken, Sebastian Schindler, Jessica B Spinelli

Cell Metab· April 2025

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A systems-level, semi-quantitative landscape of metabolic flux in C. elegans.
Hefei Zhang, Xuhang Li, L Tenzin Tseyang, Gabrielle E Giese, Hui Wang, Jessica B Spinelli

Nature· April 2025

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Rhodoquinone carries electrons in the mammalian electron transport chain.
Jonathan Valeros, Madison Jerome, Tenzin Tseyang, Paula Vo, Thang Do, Jessica B Spinelli

Cell· February 2025

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Functional Specialization of S-Adenosylmethionine Synthases Links Phosphatidylcholine to Mitochondrial Function and Stress Survival.
Athena L Munden, Dominique S Lui, Daniel P Higgins, Matthew J Fanelli, Thien-Kim Ngyuen, Jessica B Spinelli

bioRxiv· February 2025

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Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis.
Beatriz Cicuéndez, Alfonso Mora, Juan Antonio López, Andrea Curtabbi, Javier Pérez-García, Jessica B Spinelli

Nat Commun· January 2025

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Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibition.
Minwoo Nam, Wenxin Xia, Abdul Hannan Mir, Alexandra Jerrett, Jessica B Spinelli

Nat Metab· December 2024

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Multiplexed mosaic tumor models reveal natural phenotypic variations in drug response within and between populations.
Johnny X Yu, Jung Min Suh, Katerina D Popova, Kristle Garcia, Tanvi Joshi, Jessica B Spinelli

bioRxiv· December 2024

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Functional genomic screens with death rate analyses reveal mechanisms of drug action.
Megan E Honeywell, Marie S Isidor, Nicholas W Harper, Rachel E Fontana, Gavin A Birdsall, Jessica B Spinelli

Nat Chem Biol· November 2024

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Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress.
Ekaterina D Korobkina, Camila Martinez Calejman, John A Haley, Miranda E Kelly, Huawei Li, Jessica B Spinelli

Nat Metab· November 2024

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inhibits TIR-1/SARM1 induced axon degeneration.
Lauren C O'Connor, Woo Kyu Kang, Paula Vo, Jessica B Spinelli, Mark J Alkema

bioRxiv· November 2024

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Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis.
Julia A Pinette, Jacob W Myers, Woo Yong Park, Heather G Bryant, Alex M Eddie, Jessica B Spinelli

J Lipid Res· October 2024

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Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity.
Tigist Y Tamir, Shreya Chaudhary, Annie X Li, Sonia E Trojan, Cameron T Flower, Jessica B Spinelli

bioRxiv· August 2024

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Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST.
Hans-Georg Sprenger, Melanie J Mittenbühler, Yizhi Sun, Jonathan G Van Vranken, Sebastian Schindler, Jessica B Spinelli

bioRxiv· April 2024

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Selenium reduction of ubiquinone via SQOR suppresses ferroptosis.
Namgyu Lee, Sung Jin Park, Mike Lange, Tenzin Tseyang, Mihir B Doshi, Jessica B Spinelli

Nat Metab· February 2024

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MCJ: A mitochondrial target for cardiac intervention in pulmonary hypertension.
Ayelén M Santamans, Beatriz Cicuéndez, Alfonso Mora, María Villalba-Orero, Sanela Rajlic, Jessica B Spinelli

Sci Adv· January 2024

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Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells.
Mihir B Doshi, Namgyu Lee, Tenzin Tseyang, Olga Ponomarova, Hira Lal Goel, Jessica B Spinelli

Nature· November 2023

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Quantitative analysis of metabolic fluxes in brown fat and skeletal muscle during thermogenesis.
Grace Park, John A Haley, Johnny Le, Su Myung Jung, Timothy P Fitzgibbons, Jessica B Spinelli

Nat Metab· July 2023

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Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis.
Abhijit B Shinde, Elizabeth R Nunn, Genesis A Wilson, Mathew T Chvasta, Julia A Pinette, Jessica B Spinelli

J Biol Chem· May 2023

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Oxygen-Independent Assays to Measure Mitochondrial Function in Mammals.
Tenzin Tseyang, Jonathan Valeros, Paula Vo, Jessica B Spinelli

J Vis Exp· May 2023

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