Publications by authors named "Jessica Roos"

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Analysis of fatty acid-derived lipids in critically ill patients after cardiac surgery yields novel pathophysiologically relevant mediators with possible relevance for systemic inflammatory reactions.
Holger Neb, Verena Roth, Jessica Roos, Tom Bauer, Anja Urbschat

Front Immunol· May 2025

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Nitro-fatty acids: promising agents for the development of new cancer therapeutics.
Jessica Roos, Georg Manolikakes, Uwe Schlomann, Anna Klinke, Francisco J Schopfer

Trends Pharmacol Sci· November 2024

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Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome.
Camilla Brat, Hai Phong Huynh Phuoc, Omar Awad, Bhavesh S Parmar, Nadine Hellmuth, Jessica Roos

Cell Chem Biol· October 2023

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Pontine autosomal dominant microangiopathy with leukoencephalopathy: Col4A1 gene variants in the original family and sporadic stroke.
Jessica Roos, Stefanie Müller, Anne Giese, Silke Appenzeller, Erich Bernd Ringelstein

J Neurol· May 2023

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Red Blood Cell-Derived Microparticles Exert No Cancer Promoting Effects on Colorectal Cancer Cells In Vitro.
Dania Fischer, Fabian Thies, Omar Awad, Camilla Brat, Patrick Meybohm, Jessica Roos

Int J Mol Sci· August 2022

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Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport.
Astrid S Kahnt, Carlo Angioni, Tamara Göbel, Bettina Hofmann, Jessica Roos

Front Pharmacol· January 2022

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Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids.
Nadine Hellmuth, Camilla Brat, Omar Awad, Sven George, Astrid Kahnt, Jessica Roos

Front Pharmacol· November 2021

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The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer.
Matthias Piesche, Jessica Roos, Benjamin Kühn, Jasmin Fettel, Nadine Hellmuth

Front Pharmacol· September 2020

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Regulation of the Transferrin Receptor Recycling in Hepatitis C Virus-Replicating Cells.
Vanessa Haberger, Fabian Elgner, Jessica Roos, Daniela Bender, Eberhard Hildt

Front Cell Dev Biol· February 2020

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Elucidation of chemical modifier reactivity towards peptides and proteins and the analysis of specific fragmentation by matrix-assisted laser desorption/ionization collision-induced dissociation tandem mass spectrometry.
Michael Rühl, Benjamin Kühn, Jessica Roos, Thorsten J Maier, Dieter Steinhilber

Rapid Commun Mass Spectrom· May 2019

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Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity.
Jasmin Fettel, Benjamin Kühn, Nathalie A Guillen, Duran Sürün, Marcus Peters, Jessica Roos

FASEB J· February 2019

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Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells.
Benjamin Kühn, Camilla Brat, Jasmin Fettel, Nadine Hellmuth, Isabelle V Maucher, Jessica Roos

Biochem Pharmacol· September 2018

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Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.
Silke Brand, Sayantani Roy, Peter Schröder, Bernd Rathmer, Jessica Roos

Cell Chem Biol· September 2018

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Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.
Anne Louise Hansen, Gregory J Buchan, Michael Rühl, Kojiro Mukai, Sonia R Salvatore, Jessica Roos

Proc Natl Acad Sci U S A· August 2018

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Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.
Jessica Roos, Marcus Peters, Isabelle V Maucher, Benjamin Kühn, Jasmin Fettel

Antioxid Redox Signal· May 2018

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Michael acceptor containing drugs are a novel class of 5-lipoxygenase inhibitor targeting the surface cysteines C416 and C418.
Isabelle V Maucher, Michael Rühl, Simon B M Kretschmer, Bettina Hofmann, Benjamin Kühn, Jessica Roos

Biochem Pharmacol· February 2017

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Characterization of the molecular mechanism of 5-lipoxygenase inhibition by 2-aminothiazoles.
Simon B M Kretschmer, Stefano Woltersdorf, Dominik Vogt, Felix F Lillich, Michael Rühl, Jessica Roos

Biochem Pharmacol· January 2017

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Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?
Jessica Roos, Sabine Grösch, Oliver Werz, Peter Schröder, Slava Ziegler

Pharmacol Ther· January 2016

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5-Lipoxygenase is a direct p53 target gene in humans.
Bianca Gilbert, Khalil Ahmad, Jessica Roos, Christoph Lehmann, Tomohiro Chiba

Biochim Biophys Acta· August 2015

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STAT activation status differentiates leukemogenic from non-leukemogenic stem cells in AML and is suppressed by arsenic in t(6;9)-positive AML.
Claudia Oancea, Brigitte Rüster, Boris Brill, Jessica Roos, Maria Heinssmann

Genes Cancer· November 2014

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5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia.
Jessica Roos, Claudia Oancea, Maria Heinssmann, Dilawar Khan, Hannelore Held

Cancer Res· September 2014

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Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.
Khader Awwad, Svenja D Steinbrink, Timo Frömel, Nicole Lill, Johann Isaak, Jessica Roos

Antioxid Redox Signal· June 2014

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Deacetylase inhibitors modulate proliferation and self-renewal properties of leukemic stem and progenitor cells.
Annette Romanski, Kerstin Schwarz, Maren Keller, Sarah Wietbrauk, Anja Vogel, Jessica Roos

Cell Cycle· September 2012

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Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα.
Gunnar Steinert, Claudia Oancea, Jessica Roos, Heike Hagemeyer, Thorsten Maier

PLoS One· December 2011

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5-lipoxygenase: underappreciated role of a pro-inflammatory enzyme in tumorigenesis.
Dieter Steinhilber, Astrid Stefanie Fischer, Julia Metzner, Svenja Dorothea Steinbrink, Jessica Roos

Front Pharmacol· November 2011

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