Publications by authors named "Jessica Thaxton"

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Atlas-Guided Discovery of Transcription Factors for T Cell Programming.
H Kay Chung, Cong Liu, Anamika Battu, Alexander N Jambor, Brandon M Pratt, Jessica E Thaxton

bioRxiv· November 2025

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Intra-tumoral hypoxia promotes CD8 T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4.
Coral Del Mar Alicea Pauneto, Brian P Riesenberg, Evelyn J Gandy, Andrew S Kennedy, Genevieve T Clutton, Jessica E Thaxton

Immunity· October 2025

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Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment.
William D Green, Amber Gomez, Alec L Plotkin, Brandon M Pratt, Emily F Merritt, Jessica E Thaxton

Immunity· July 2025

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Acetyl-CoA carboxylase obstructs CD8 T cell lipid utilization in the tumor microenvironment.
Elizabeth G Hunt, Katie E Hurst, Brian P Riesenberg, Andrew S Kennedy, Evelyn J Gandy, Jessica E Thaxton

Cell Metab· May 2024

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Progressively Enhancing Stemness of Adoptively Transferred T Cells with PI3Kδ Blockade Improves Metabolism and Antitumor Immunity.
Guillermo O Rangel Rivera, Connor J Dwyer, Hannah M Knochelmann, Aubrey S Smith, Bülent Arman Aksoy, Jessica E Thaxton

Cancer Res· January 2024

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The degree of T cell stemness differentially impacts the potency of adoptive cancer immunotherapy in a Lef-1 and Tcf-1 dependent manner.
Guillermo O Rangel Rivera, Connor J Dwyer, Hannah M Knochelmann, Aubrey S Smith, Arman Aksoy, Jessica E Thaxton

bioRxiv· March 2023

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Stress-Mediated Attenuation of Translation Undermines T-cell Activity in Cancer.
Brian P Riesenberg, Elizabeth G Hunt, Megan D Tennant, Katie E Hurst, Alex M Andrews, Jessica E Thaxton

Cancer Res· December 2022

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The ER-Mitochondria Interface as a Dynamic Hub for T Cell Efficacy in Solid Tumors.
Elizabeth G Hunt, Alex M Andrews, Sydney R Larsen, Jessica E Thaxton

Front Cell Dev Biol· April 2022

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B cells imprint adoptively transferred CD8 T cells with enhanced tumor immunity.
Aubrey S Smith, Hannah M Knochelmann, Megan M Wyatt, Guillermo O Rangel Rivera, Amalia M Rivera-Reyes, Jessica E Thaxton

J Immunother Cancer· January 2022

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Fundamentals of T Cell Metabolism and Strategies to Enhance Cancer Immunotherapy.
Guillermo O Rangel Rivera, Hannah M Knochelmann, Connor J Dwyer, Aubrey S Smith, Megan M Wyatt, Jessica E Thaxton

Front Immunol· September 2021

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Immune Responses Vary in Preinvasive Colorectal Lesions by Tumor Location and Histology.
Kristin Wallace, Georges J El Nahas, Christine Bookhout, Jessica E Thaxton, David N Lewin

Cancer Prev Res (Phila)· September 2021

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Stress relief for cancer immunotherapy: implications for the ER stress response in tumor immunity.
Alex M Andrews, Megan D Tennant, Jessica E Thaxton

Cancer Immunol Immunother· May 2021

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Considerations for treatment duration in responders to immune checkpoint inhibitors.
Thomas U Marron, Aideen E Ryan, Sangeetha M Reddy, Sabina Kaczanowska, Rania H Younis, Jessica E Thaxton

J Immunother Cancer· March 2021

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Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.
Anita K Mehta, Emily M Cheney, Christina A Hartl, Constantia Pantelidou, Madisson Oliwa, Jessica E Thaxton

Nat Cancer· January 2021

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Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8 T cells.
Connor J Dwyer, Dimitrios C Arhontoulis, Guillermo O Rangel Rivera, Hannah M Knochelmann, Aubrey S Smith, Jessica E Thaxton

Eur J Immunol· September 2020

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An observational study and randomized trial of stress reactivity in cancer disparities.
Chanita Hughes Halbert, Melanie S Jefferson, Carla Danielson, Brett Froeliger, Antonio Giordano, Jessica E Thaxton

Health Psychol· September 2020

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Remodeling Translation Primes CD8 T-cell Antitumor Immunity.
Katie E Hurst, Kiley A Lawrence, Rob A Robino, Lauren E Ball, Dongjun Chung, Jessica E Thaxton

Cancer Immunol Res· May 2020

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Endoplasmic Reticulum Protein Disulfide Isomerase Shapes T Cell Efficacy for Adoptive Cellular Therapy of Tumors.
Katie E Hurst, Kiley A Lawrence, Lety Reyes Angeles, Zhiwei Ye, Jie Zhang, Jessica E Thaxton

Cells· November 2019

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Endoplasmic Reticulum Stress Contributes to Mitochondrial Exhaustion of CD8 T Cells.
Katie E Hurst, Kiley A Lawrence, Matthew T Essman, Zeke J Walton, Lee R Leddy, Jessica E Thaxton

Cancer Immunol Res· March 2019

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Modulation of Endoplasmic Reticulum Stress Controls CD4 T-cell Activation and Antitumor Function.
Jessica E Thaxton, Caroline Wallace, Brian Riesenberg, Yongliang Zhang, Chrystal M Paulos

Cancer Immunol Res· August 2017

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Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.
Ephraim A Ansa-Addo, Jessica Thaxton, Feng Hong, Bill X Wu, Yongliang Zhang

Curr Top Med Chem· February 2017

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To affinity and beyond: harnessing the T cell receptor for cancer immunotherapy.
Jessica E Thaxton, Zihai Li

Hum Vaccin Immunother· October 2015

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GP96 is a GARP chaperone and controls regulatory T cell functions.
Yongliang Zhang, Bill X Wu, Alessandra Metelli, Jessica E Thaxton, Feng Hong

J Clin Invest· February 2015

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Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells.
Jessica E Thaxton, Bei Liu, Pan Zheng, Yang Liu, Zihai Li

J Immunol· June 2014

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NKG2D blockade inhibits poly(I:C)-triggered fetal loss in wild type but not in IL-10-/- mice.
Jessica E Thaxton, Tania Nevers, Eliana O Lippe, Sandra M Blois, Shigeru Saito

J Immunol· April 2013

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