Publications by authors named "Ji-wang Chern"

Claim this Profile
A
A Novel HDAC6 Inhibitor Enhances the Efficacy of Paclitaxel Against Ovarian Cancer Cells.
An-Jui Chi, Jui-Ling Hsu, Yun-Xin Xiao, Ji-Wang Chern, Jih-Hwa Guh

Molecules· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Disrupted target binding with acryloyl group as potential Bcr-Abl/C-Src dual kinase inhibitor optimization strategies with maintained antitumor activity.
Ching Lin, Hsin-Yi Chiang, Grace Shiahuy Chen, Ji-Wang Chern, Chao-Wu Yu

Bioorg Med Chem Lett· April 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of novel anaplastic lymphoma kinase (ALK) and histone deacetylase (HDAC) dual inhibitors exhibiting antiproliferative activity against non-small cell lung cancer.
Kang-Li Wang, Tsung-Yu Yeh, Pei-Chen Hsu, Tzu-Hsuan Wong, Jia-Rong Liu, Ji-Wang Chern

J Enzyme Inhib Med Chem· December 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancer.
Pei-Chen Ye, Wohn-Jenn Leu, Tsung-Yu Yeh, Yu-Tung Hsu, Yi-Chin Lin, Ji-Wang Chern

Prostate· May 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
J
J24335 exerts neuroprotective effects against 6-hydroxydopamine-induced lesions in PC12 cells and mice.
Zhijian Pan, Min Shao, Chen Zhao, Xuanjun Yang, Haitao Li, Ji-Wang Chern

Eur J Pharm Sci· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Antagonizing pathological α-synuclein-mediated neurodegeneration by J24335 via the activation of immunoproteasome.
Zhijian Pan, Chao-Wu Yu, Chen Zhao, Min Shao, Xuanjun Yang, Ji-Wang Chern

Toxicol Appl Pharmacol· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of HDAC6, HDAC8, and 6/8 Inhibitors and Development of Cell-Based Drug Screening Models for the Treatment of TGF-β-Induced Idiopathic Pulmonary Fibrosis.
Wei-Chieh Yu, Tsung-Yu Yeh, Chih-Hung Ye, Patrick Chun Theng Chong, Yi-Hsun Ho, Ji-Wang Chern

J Med Chem· August 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Inhibitor development of MTH1 via high-throughput screening with fragment based library and MTH1 substrate binding cavity.
Cheng Peng, Yu-Hsuan Li, Chao-Wu Yu, Ze-Hua Cheng, Jia-Rong Liu, Ji-Wang Chern

Bioorg Chem· May 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting α-Helix Backbone Oxygen by Halogen Bonding.
Chao-Ming Hsieh, Chun-Yi Chen, Ji-Wang Chern, Nei-Li Chan

J Med Chem· August 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
4
4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1.
Ajit Dhananjay Jagtap, Nagendra B Kondekar, Pei-Yun Hung, Chen-En Hsieh, Chia-Ron Yang, Ji-Wang Chern

Bioorg Chem· January 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
High-selective HDAC6 inhibitor promotes HDAC6 degradation following autophagy modulation and enhanced antitumor immunity in glioblastoma.
Jia-Rong Liu, Chao-Wu Yu, Pei-Yun Hung, Ling-Wei Hsin, Ji-Wang Chern

Biochem Pharmacol· May 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel histone deacetylase inhibitors and embryo aggregation enhance cloned embryo development and ES cell derivation in pigs.
Chawalit Siriboon, Tzai-Shiuan Li, Chao-Wu Yu, Ji-Wang Chern, Jyh-Cherng Ju

PLoS One· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
Quinazolin-2,4-dione-Based Hydroxamic Acids as Selective Histone Deacetylase-6 Inhibitors for Treatment of Non-Small Cell Lung Cancer.
Chao-Wu Yu, Pei-Yun Hung, Hui-Ting Yang, Yi-Hsun Ho, Hsing-Yi Lai, Ji-Wang Chern

J Med Chem· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Acrylamide Functional Group Incorporation Improves Drug-like Properties: An Example with EGFR Inhibitors.
Kuen-Da Wu, Grace Shiahuy Chen, Jia-Rong Liu, Chen-En Hsieh, Ji-Wang Chern

ACS Med Chem Lett· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A highly HDAC6-selective inhibitor acts as a fluorescent probe.
Yi-Hsun Ho, Kuang-Jui Wang, Pei-Yun Hung, Yi-Sheng Cheng, Jia-Rong Liu, Ji-Wang Chern

Org Biomol Chem· October 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
Ureas: Applications in Drug Design.
Ajit Dhananjay Jagtap, Nagendra Bharatrao Kondekar, Amit A Sadani, Ji-Wang Chern

Curr Med Chem· June 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth.
Pei-Teh Chang, Rahul Subhash Talekar, Fan-Lu Kung, Ting-Rong Chern, Chen-Wei Huang, Ji-Wang Chern

Neuropharmacology· May 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Novel acylureidoindolin-2-one derivatives as dual Aurora B/FLT3 inhibitors for the treatment of acute myeloid leukemia.
Ajit Dhananjay Jagtap, Pei-Teh Chang, Jia-Rong Liu, Hsiao-Chun Wang, Nagendra B Kondekar, Ji-Wang Chern

Eur J Med Chem· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Bioisosteric replacement of an acylureido moiety attached to an indolin-2-one scaffold with a malonamido or a 2/4-pyridinoylamido moiety produces a selectively potent Aurora-B inhibitor.
Hsiao-Chun Wang, Ajit Dhananjay Jagtap, Pei-Teh Chang, Jia-Rong Liu, Chih-Peng Liu, Ji-Wang Chern

Eur J Med Chem· September 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Q
Quinazolin-4-one derivatives as selective histone deacetylase-6 inhibitors for the treatment of Alzheimer's disease.
Chao-Wu Yu, Pei-Teh Chang, Ling-Wei Hsin, Ji-Wang Chern

J Med Chem· September 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Efficient microwave-assisted Pd-catalyzed hydroxylation of aryl chlorides in the presence of carbonate.
Chao-Wu Yu, Grace S Chen, Chen-Wei Huang, Ji-Wang Chern

Org Lett· July 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of N-arylalkyl-3-hydroxy-4-oxo-3,4-dihydroquinazolin-2-carboxamide derivatives as HCV NS5B polymerase inhibitors.
Ravindra Ramesh Deore, Grace Shiahuy Chen, Pei-Teh Chang, Ting-Rong Chern, Shin-Yu Lai, Ji-Wang Chern

ChemMedChem· May 2012

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.
Chen-Ming Tan, Grace Shiahuy Chen, Chien-Shu Chen, Pei-Teh Chang, Ji-Wang Chern

Bioorg Med Chem· November 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs as potential antitumor agents.
Ya-Ching Shen, Yao-To Chang, Chun-Ling Lin, Chia-Ching Liaw, Yao Haur Kuo, Ji-Wang Chern

Mar Drugs· February 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of anti-microtubule N-(2-Arylindol-7-yl)benzenesulfonamide derivatives and their antitumor mechanisms.
Chun-Tang Chiou, Grace Shiahuy Chen, Meng-Ling Chen, Huoming Li, Lei Shi, Ji-Wang Chern

ChemMedChem· September 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis