Publications by authors named "Nei-Li Chan"

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Structural insights into the assembly of type IIA topoisomerase DNA cleavage-religation center.
Ko-Ting Liu, Shin-Fu Chen, Nei-Li Chan

Nucleic Acids Res· September 2024

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Spectroscopic and computational studies of a bifunctional iron- and 2-oxoglutarate dependent enzyme, AsqJ.
Shan Xue, Yijie Tang, Igor V Kurnikov, Hsuan-Jen Liao, Jikun Li, Nei-Li Chan, Wei-Chen Chang

Methods Enzymol· September 2024

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Biochemical characterization of the meiosis-essential yet evolutionarily divergent topoisomerase VIB-like protein MTOPVIB from Arabidopsis thaliana.
Hsin-Wen Chen, Hsin-Yi Yeh, Chih-Chiang Chang, Wei-Chen Kuo, Sheng-Wei Lin, Nei-Li Chan

Nucleic Acids Res· May 2024

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Sequential Phosphorylation of Hepatitis C Virus NS5A Protein Requires the ATP-Binding Domain of NS3 Helicase.
Chun-Chiao Yu, Pei-Chen Lin, Cho-Han Chiang, Shu-Tang Jen, Yen-Ling Lai, Nei-Li Chan

J Virol· April 2022

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Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase.
Haoyu Tang, Min-Hao Wu, Hsiao-Yu Lin, Meng-Ru Han, Yueh-Hua Tu, Nei-Li Chan, Wei-Chen Chang

Proc Natl Acad Sci U S A· January 2022

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Harnessing the Substrate Promiscuity of Dioxygenase AsqJ and Developing Efficient Chemoenzymatic Synthesis for Quinolones.
Haoyu Tang, Yijie Tang, Igor V Kurnikov, Hsuan-Jen Liao, Nei-Li Chan, Wei-Chen Chang

ACS Catal· June 2021

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Structure of Human Phosphodiesterase 5A1 Complexed with Avanafil Reveals Molecular Basis of Isoform Selectivity and Guidelines for Targeting α-Helix Backbone Oxygen by Halogen Bonding.
Chao-Ming Hsieh, Chun-Yi Chen, Ji-Wang Chern, Nei-Li Chan

J Med Chem· August 2020

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Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate.
Jikun Li, Hsuan-Jen Liao, Yijie Tang, Jhih-Liang Huang, Lide Cha, Wei-Chen Chang, Nei-Li Chan

J Am Chem Soc· April 2020

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Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis.
Pei-Fang Hung, Tse-Ming Hong, Che-Chang Chang, Chung-Lieh Hung, Yuan-Ling Hsu, Yih-Leong Chang, Gee-Chen Chang, Nei-Li Chan

J Exp Clin Cancer Res· January 2019

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Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate.
Shin-Fu Chen, Nan-Lan Huang, Jung-Hsin Lin, Chyuan-Chuan Wu, Ying-Ren Wang, Nei-Li Chan

Nat Commun· August 2018

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Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation.
Hsuan-Jen Liao, Jikun Li, Jhih-Liang Huang, Madison Davidson, Igor Kurnikov, Nei-Li Chan, Wei-Chen Chang

Angew Chem Int Ed Engl· February 2018

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Topoisomerases as anticancer targets.
Justine L Delgado, Chao-Ming Hsieh, Nei-Li Chan, Hiroshi Hiasa

Biochem J· January 2018

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Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.
Ying-Ren Wang, Shin-Fu Chen, Chyuan-Chuan Wu, Yi-Wen Liao, Te-Sheng Lin, Nei-Li Chan

Nucleic Acids Res· October 2017

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Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.
Ying-Ren Wang, Shin-Fu Chen, Chyuan-Chuan Wu, Yi-Wen Liao, Te-Sheng Lin, Nei-Li Chan

Nucleic Acids Res· October 2017

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Functional characterization of the meiosis-specific DNA double-strand break inducing factor SPO-11 from C. elegans.
Hsin-Yi Yeh, Sheng-Wei Lin, Yi-Chun Wu, Nei-Li Chan, Peter Chi

Sci Rep· May 2017

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Correction: DNA Topoisomerase II Is Involved in Regulation of Cyst Wall Protein Genes and Differentiation in Giardia lamblia.
Bo-Chi Lin, Li-Hsin Su, Shih-Che Weng, Yu-Jiao Pan, Nei-Li Chan

PLoS Negl Trop Dis· January 2017

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Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Yi-Ru Lee, Te-Sheng Lin, Shu-Jung Lai, Mu-Sen Liu, Mei-Chin Lai, Nei-Li Chan

Sci Rep· December 2016

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Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation.
Yi-Hsuan Chen, Hua-Yi Hsu, Ming-Tyng Yeh, Chen-Cheng Chen, Chang-Yu Huang, Zee-Fen Chang, Nei-Li Chan

J Med Chem· November 2016

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SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation.
Cheng-Hui Tsai, Yun-Ju Chen, Chia-Jung Yu, Shiou-Ru Tzeng, I-Chen Wu, Nei-Li Chan

Cancer Res· October 2016

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Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy.
Camilo F Martinez-Farina, Nicole McCormick, Andrew W Robertson, Helen Clement, Alison Jee, Nei-Li Chan

Org Biomol Chem· November 2015

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Structural basis of the mercury(II)-mediated conformational switching of the dual-function transcriptional regulator MerR.
Chih-Chiang Chang, Li-Ying Lin, Xiao-Wei Zou, Chieh-Chen Huang, Nei-Li Chan

Nucleic Acids Res· September 2015

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Structural basis of antizyme-mediated regulation of polyamine homeostasis.
Hsiang-Yi Wu, Shin-Fu Chen, Ju-Yi Hsieh, Fang Chou, Yu-Hsuan Wang, Nei-Li Chan

Proc Natl Acad Sci U S A· September 2015

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Structural characteristics of the nonallosteric human cytosolic malic enzyme.
Ju-Yi Hsieh, Shao-Yu Li, Meng-Chun Chen, Pai-Chun Yang, Hui-Yi Chen, Nei-Li Chan

Biochim Biophys Acta· October 2014

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On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs.
Chyuan-Chuan Wu, Yi-Ching Li, Ying-Ren Wang, Tsai-Kun Li, Nei-Li Chan

Nucleic Acids Res· December 2013

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DNA topoisomerase II is involved in regulation of cyst wall protein genes and differentiation in Giardia lamblia.
Bo-Chi Lin, Li-Hsin Su, Shih-Che Weng, Yu-Jiao Pan, Nei-Li Chan

PLoS Negl Trop Dis· November 2013

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