Publications by authors named "Jim Vadolas"

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A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells.
Sara E Howden, Bradley McColl, Astrid Glaser, Jim Vadolas, Steven Petrou, Melissa H Little, Andrew G Elefanty, Edouard G Stanley

Stem Cell Reports· September 2016

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Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice.
Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas

Sci Rep· January 2025

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Cognitive impairment and hippocampal neuronal damage in β-thalassaemia mice.
Nuttanan Pholngam, Parinda Jamrus, Kittikun Viwatpinyo, Benjaporn Kiatpakdee, Jim Vadolas

Sci Rep· May 2024

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Interplay between α-thalassemia and β-hemoglobinopathies: Translating genotype-phenotype relationships into therapies.
Jim Vadolas, Tiwaporn Nualkaew, Hsiao P J Voon, Shahla Vilcassim, George Grigoriadis

Hemasphere· May 2024

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A comprehensive study of immune function and immunophenotyping of white blood cells from β-thalassaemia/HbE patients on hydroxyurea supports the safety of the drug.
Sirikwan Siriworadetkun, Chayada Thiengtavor, Rattanawan Thubthed, Kittiphong Paiboonsukwong, Suthat Fucharoen, Jim Vadolas

Br J Haematol· February 2023

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Increased autophagy leads to decreased apoptosis during β-thalassaemic mouse and patient erythropoiesis.
Pornthip Chaichompoo, Ramaneeya Nithipongvanitch, Wasinee Kheansaard, Alisa Tubsuwan, Kanitta Srinoun, Jim Vadolas

Sci Rep· November 2022

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Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering.
Mariella Obermeier, Jim Vadolas, Stefaan Verhulst, Ellen Goossens, Yoni Baert

Front Cell Dev Biol· June 2022

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Impaired neutrophil extracellular trap formation in β-thalassaemia/HbE.
Rattanawan Thubthed, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas

Sci Rep· February 2022

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Coordinated β-globin expression and α2-globin reduction in a multiplex lentiviral gene therapy vector for β-thalassemia.
Tiwaporn Nualkaew, Karine Sii-Felice, Marie Giorgi, Bradley McColl, Julie Gouzil, Jim Vadolas

Mol Ther· September 2021

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SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of β-thalassaemia.
Jim Vadolas, Garrett Z Ng, Kai Kysenius, Peter J Crouch, Sibylle Dames

Br J Haematol· July 2021

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Trienone analogs of curcuminoids induce fetal hemoglobin synthesis via demethylation at γ-globin gene promoter.
Khanita Nuamsee, Thipphawan Chuprajob, Wachirachai Pabuprapap, Pornrutsami Jintaridth, Thongperm Munkongdee, Jim Vadolas

Sci Rep· April 2021

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Elevated levels of circulating monocytic myeloid derived suppressor cells in splenectomised β-thalassaemia/HbE patients.
Sirikwan Siriworadetkun, Rattanawan Thubthed, Chayada Thiengtavor, Kittiphong Paiboonsukwong, Archrob Khuhapinant, Jim Vadolas

Br J Haematol· November 2020

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Increased ferritin levels in non-transfusion-dependent β°-thalassaemia/HbE are associated with reduced CXCR2 expression and neutrophil migration.
Chayada Thiengtavor, Sirikwan Siriworadetkun, Kittiphong Paiboonsukwong, Suthat Fucharoen, Kovit Pattanapanyasat, Jim Vadolas

Br J Haematol· April 2020

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Reduced PU.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients.
Panjaree Siwaponanan, Jurre Ynze Siegers, Razi Ghazali, Thian Ng, Bradley McColl, Jim Vadolas

Blood· June 2017

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Epigenetic interplay at the β-globin locus.
Wei Shern Lee, Bradley McColl, Jovana Maksimovic, Jim Vadolas

Biochim Biophys Acta Gene Regul Mech· April 2017

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Animal models of β-hemoglobinopathies: utility and limitations.
Bradley McColl, Jim Vadolas

J Blood Med· November 2016

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Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.
Kamonshanok Kraidith, Saovaros Svasti, Jarinthorn Teerapornpuntakit, Jim Vadolas, Rattana Chaimana

Am J Physiol Endocrinol Metab· July 2016

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GFP to BFP Conversion: A Versatile Assay for the Quantification of CRISPR/Cas9-mediated Genome Editing.
Astrid Glaser, Bradley McColl, Jim Vadolas

Mol Ther Nucleic Acids· July 2016

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The therapeutic potential of genome editing for β-thalassemia.
Astrid Glaser, Bradley McColl, Jim Vadolas

F1000Res· February 2016

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Site-specific integration of bacterial artificial chromosomes into human cells.
Bradley McColl, Sara Howden, Jim Vadolas

Methods Mol Biol· May 2015

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Generation of BAC reporter cell lines for drug discovery.
Betty R Kao, Bradley McColl, Jim Vadolas

Methods Mol Biol· May 2015

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Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin.
Beeke Wienert, Alister P W Funnell, Laura J Norton, Richard C M Pearson, Lorna E Wilkinson-White, Jim Vadolas

Nat Commun· May 2015

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An in vivo model for analysis of developmental erythropoiesis and globin gene regulation.
Bradley McColl, Betty R Kao, Preeyachan Lourthai, Kasey Chan, Hady Wardan, Jim Vadolas

FASEB J· May 2014

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Transcriptional regulators Myb and BCL11A interplay with DNA methyltransferase 1 in developmental silencing of embryonic and fetal β-like globin genes.
Mark Roosjen, Bradley McColl, Betty Kao, Linden J Gearing, Marnie E Blewitt, Jim Vadolas

FASEB J· April 2014

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A reduced curcuminoid analog as a novel inducer of fetal hemoglobin.
Nattawara Chaneiam, Chatchawan Changtam, Thongperm Mungkongdee, Umaporn Suthatvoravut, Pranee Winichagoon, Jim Vadolas

Ann Hematol· March 2013

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