Publications by authors named "Jimmy Beckers"

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C21ORF2 mutations point towards primary cilia dysfunction in amyotrophic lateral sclerosis.
Mathias De Decker, Pavol Zelina, Thomas G Moens, Jimmy Beckers, Matilde Contardo

Brain· March 2025

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The role of autophagy in the pathogenesis and treatment of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).
Jimmy Beckers, Philip Van Damme

Autophagy Rep· March 2025

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A pathogenic mutation in the ALS/FTD gene VCP induces mitochondrial hypermetabolism by modulating the permeability transition pore.
Silke Vanderhaeghe, Jovan Prerad, Arun Kumar Tharkeshwar, Elien Goethals, Katlijn Vints, Jimmy Beckers

Acta Neuropathol Commun· October 2024

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Toxic gain-of-function mechanisms in ALS-FTD neurons drive autophagy and lysosome dysfunction.
Jimmy Beckers, Philip Van Damme

Autophagy· September 2024

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A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons.
Jimmy Beckers, Arun Kumar Tharkeshwar, Laura Fumagalli, Matilde Contardo, Evelien Van Schoor

Acta Neuropathol Commun· September 2023

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HNRNPK alleviates RNA toxicity by counteracting DNA damage in C9orf72 ALS.
Elke Braems, Valérie Bercier, Evelien Van Schoor, Kara Heeren, Jimmy Beckers

Acta Neuropathol· September 2022

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The role of inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD.
Pegah Masrori, Jimmy Beckers, Helena Gossye, Philip Van Damme

Mol Neurodegener· March 2022

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C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels.
Jimmy Beckers, Arun Kumar Tharkeshwar, Philip Van Damme

Autophagy· November 2021

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Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition.
Katarina Stoklund Dittlau, Emily N Krasnow, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Jimmy Beckers

Stem Cell Reports· September 2021

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Generation of Human Motor Units with Functional Neuromuscular Junctions in Microfluidic Devices.
Katarina Stoklund Dittlau, Emily N Krasnow, Laura Fumagalli, Tijs Vandoorne, Pieter Baatsen, Jimmy Beckers

J Vis Exp· September 2021

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HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations.
Raheem Fazal, Steven Boeynaems, Ann Swijsen, Mathias De Decker, Laura Fumagalli, Jimmy Beckers

EMBO J· April 2021

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-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.
Laura Fumagalli, Florence L Young, Steven Boeynaems, Mathias De Decker, Arpan R Mehta, Jimmy Beckers

Sci Adv· April 2021

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Recent Insights on Alzheimer's Disease Originating from Yeast Models.
David Seynnaeve, Mara Del Vecchio, Gernot Fruhmann, Joke Verelst, Melody Cools, Jimmy Beckers

Int J Mol Sci· July 2018

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