Publications by authors named "JingRui Chai"

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Astrocyte-mediated central amygdala microcircuit gates comorbid anxiety symptoms in chronic pain.
Gui-Ying Zan, Song-Yu Yao, Ying-Zhi Deng, Yun-Hao Jiang, Ru-Feng Ye, Jing-Rui Chai

Neuron· December 2025

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Astrocyte-mediated central amygdala microcircuit gates comorbid anxiety symptoms in chronic pain.
Gui-Ying Zan, Song-Yu Yao, Ying-Zhi Deng, Yun-Hao Jiang, Ru-Feng Ye, Jing-Rui Chai

Neuron· December 2025

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Correction to "Structure-Activity Relationship of -Cyclopropylmethyl-7α-[-(arylcarboxamido)phenyl]-6,14-ethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists".
Linghui Kong, Songyu Yao, Denggao Zhang, Jiangwen Gui, Baiyu Chen, Jingrui Chai

J Med Chem· December 2025

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Structure-Activity Relationship of -Cyclopropylmethyl-7α-[-(arylcarboxamido)phenyl]-6,14-ethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists.
Linghui Kong, Songyu Yao, Denggao Zhang, Jiangwen Gui, Baiyu Chen, Jingrui Chai

J Med Chem· August 2025

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Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference.
Ying-Jie Cheng, Gui-Ying Zan, Ying-Zhi Deng, Di Deng, Man-Qing Wu, Jing-Rui Chai

Nat Commun· May 2025

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Dezocine Exerts Analgesic Effects in Chronic Pain by Activation of κ- and μ-Opioid Receptors and Inhibition of Norepinephrine and Serotonin Reuptake.
Zihan Liu, Anan Liu, Jing Chen, Jing-Rui Chai, Panwen Liu

Pain Res Manag· April 2025

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Discovery of an Ortho-Substituted -Cyclopropylmethyl-7α-phenyl-6,14-ethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect.
Zixiang Li, Rufeng Ye, Qian He, Jiashuo Lu, Yanting Sun, Jingrui Chai

J Med Chem· May 2024

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Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone.
Linghui Kong, Kuan Ning, Xiao Liu, Jiashuo Lu, Baiyu Chen, Jing-Rui Chai

Eur J Med Chem· October 2023

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Prelimbic cortex dynorphin/κ opioid receptor system modulates methamphetamine-induced cognitive impairment.
Ying-Jie Cheng, Ying-Zhi Deng, Di Deng, Man-Qing Wu, Jing-Rui Chai

Addict Biol· September 2023

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Author Correction: Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress.
Gui-Ying Zan, Xiang Sun, Yu-Jun Wang, Rui Liu, Chen-Yao Wang, Jing-Rui Chai

Acta Pharmacol Sin· May 2023

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Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.
Linghui Kong, Xuelian Shu, Siyuan Tang, Rongrong Ye, Huijiao Sun, Jingrui Chai

J Med Chem· August 2022

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Antinociceptive activities and mechanism of action of Cepharanthine.
Xiang-Yan Wei, Jian-Dong Long, Jing-Rui Chai, Jing Chen, Jian-Ping Gao

Biochem Biophys Res Commun· July 2022

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Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion.
Yuan-Yuan Wei, Yan Ma, Song-Yu Yao, Ling-Hui Kong, Xiao Liu, Jing-Rui Chai

Acta Pharmacol Sin· June 2022

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Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress.
Gui-Ying Zan, Xiang Sun, Yu-Jun Wang, Rui Liu, Chen-Yao Wang, Jing-Rui Chai

Acta Pharmacol Sin· March 2022

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Alteration of twinfilin1 expression underlies opioid withdrawal-induced remodeling of actin cytoskeleton at synapses and formation of aversive memory.
Yu-Jun Wang, Chuan Yu, Wei-Wei Wu, Yun-Yue Ju, Yao Liu, Jing-Rui Chai

Mol Psychiatry· November 2021

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Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence.
Gui-Ying Zan, Yu-Jun Wang, Xue-Ping Li, Jun-Fan Fang, Song-Yu Yao, Jing-Rui Chai

Cell Rep· November 2021

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Discovery of an -Substituted -Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.
Qian He, Yuanyuan Wei, Xiao Liu, Rongrong Ye, Linghui Kong, Jingrui Chai

J Med Chem· August 2021

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Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3,4)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic.
Huoming Huang, Xueping Li, Peng Xie, Xinwei Li, XueJun Xu, JingRui Chai

J Med Chem· July 2021

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Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation.
Ying-Zhi Deng, Yu-Chen Lu, Wei-Wei Wu, Li Cheng, Gui-Ying Zan, Jing-Rui Chai

Neuropharmacology· May 2020

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Pharmacological Characterization of Dezocine, a Potent Analgesic Acting as a κ Partial Agonist and μ Partial Agonist.
Yu-Hua Wang, Jing-Rui Chai, Xue-Jun Xu, Ru-Feng Ye, Gui-Ying Zan

Sci Rep· September 2018

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Dissociative role for dorsal hippocampus in mediating heroin self-administration and relapse through CDK5 and RhoB signaling revealed by proteomic analysis.
Zhong-Guo Chen, Xing Liu, Weisheng Wang, Fan Geng, Jing Gao, Jing-Rui Chai

Addict Biol· November 2017

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Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with κ agonist and μ agonist/antagonist activity.
Jian-Feng Sun, Yu-Hua Wang, Jing-Rui Chai, Fu-Ying Li, Ai Hang

Eur J Pharmacol· October 2014

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Single-chain variable fragments antibody of CART inhibits the expression of cocaine-induced behavioral sensitization.
Jingrui Chai, Fangqiong Hu, Yimin Yuan, Changlin Lu, Zhendong You

Neuroreport· June 2011

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