Publications by authors named "Jinggen Liu"

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Identification and validation of Slit3 as a depression biomarker modulating dynorphinergic neurons in the hypothalamic paraventricular nucleus.
Yun-Hao Jiang, Cai-Yu Zhai, Jia-Na Ying, Shuo Wu, Jing-Gen Liu

Neuropharmacology· February 2026

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Design, synthesis, and biological activity of novel para-substituted phenylamino and phenyl derivatives of northebaine as selective delta opioid receptor agonists.
Denggao Zhang, Jiangwen Gui, Linghui Kong, Chuyuan Hu, Xinmeng Kou, Min Liu, Jinggen Liu

Bioorg Med Chem· December 2025

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Astrocyte-mediated central amygdala microcircuit gates comorbid anxiety symptoms in chronic pain.
Gui-Ying Zan, Song-Yu Yao, Ying-Zhi Deng, Yun-Hao Jiang, Ru-Feng Ye, Zhi-Qiang Liu, Jing-Gen Liu

Neuron· December 2025

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Astrocyte-mediated central amygdala microcircuit gates comorbid anxiety symptoms in chronic pain.
Gui-Ying Zan, Song-Yu Yao, Ying-Zhi Deng, Yun-Hao Jiang, Ru-Feng Ye, Zhi-Qiang Liu, Jing-Gen Liu

Neuron· December 2025

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Astroglial kappa opioid receptor-mediated reduction of glutamate exchanger xCT in the prelimbic cortex underlies chronic stress-induced depressive-like behaviors.
Yexiang Chen, Liu-Bin Guo, Gui-Ying Zan, Chi Xu, Song-Yu Yao, Zihan Liu, Boyu Liu, Jing-Gen Liu

Mol Psychiatry· December 2025

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Correction to "Structure-Activity Relationship of -Cyclopropylmethyl-7α-[-(arylcarboxamido)phenyl]-6,14-ethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists".
Linghui Kong, Songyu Yao, Denggao Zhang, Jiangwen Gui, Baiyu Chen, Min Liu, Xiaoning Liu, Zihan Liu, Anan Liu, Jinggen Liu

J Med Chem· December 2025

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Structure-Activity Relationship of -Cyclopropylmethyl-7α-[-(arylcarboxamido)phenyl]-6,14-ethano-tetrahydronorthebaines as Potent and Selective Kappa Opioid Receptor Agonists.
Linghui Kong, Songyu Yao, Denggao Zhang, Jiangwen Gui, Baiyu Chen, Min Liu, Xiaoning Liu, Zihan Liu, Anan Liu, Jinggen Liu

J Med Chem· August 2025

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CXCR2 modulates chronic pain comorbid depression in mice by regulating adult neurogenesis in the ventral dentate gyrus.
Xiao-Jie Li, Shuo Wu, Zi-Han Liu, An-An Liu, Hui-Sheng Peng, Jing-Gen Liu

Acta Pharmacol Sin· June 2025

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Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities.
Siyuan Tang, Shuyang Hu, Lijing Feng, Linghui Kong, Jiangwen Gui, Zi-Han Liu, An-An Liu, Xiao Liu, Xiaoning Liu, Panwen Liu, Min Liu, Jinggen Liu

Eur J Med Chem· May 2025

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Oxytocinergic input from the paraventricular nucleus to the nucleus accumbens core modulates methamphetamine-conditioned place preference.
Ying-Jie Cheng, Gui-Ying Zan, Ying-Zhi Deng, Di Deng, Man-Qing Wu, Jing-Gen Liu

Nat Commun· May 2025

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Dezocine Exerts Analgesic Effects in Chronic Pain by Activation of κ- and μ-Opioid Receptors and Inhibition of Norepinephrine and Serotonin Reuptake.
Zihan Liu, Anan Liu, Jing Chen, Jing-Rui Chai, Panwen Liu, Jing-Gen Liu

Pain Res Manag· April 2025

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MeCP2 Modulates Depression-Like Behaviors Comorbid to Chronic Pain by Regulating Adult Hippocampal Neurogenesis.
Yanting Sun, Ying Zhang, Yexiang Chen, Huisheng Peng, Tiantian Cheng, Jing-Gen Liu

CNS Neurosci Ther· March 2025

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E
Exosomes released from immature neurons regulate adult neural stem cell differentiation through microRNA-7a-5p.
Xiujian Sun, Yexiang Chen, Ying Zhang, Tiantian Cheng, Huisheng Peng, Jing-Gen Liu

Stem Cells· February 2025

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B
Berberine alleviates chronic pain-induced anxiety-like behaviors by inhibiting the activation of VLT-projecting cACC (Cg2) neurons.
Min He, Ye-Xiang Chen, Pei-Pei Feng, Jie Chen, Chi Xu, Bo-Yu Liu, Jing-Gen Liu

Commun Biol· December 2024

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Modulation of Comorbid Chronic Neuropathic Pain and Anxiety-Like Behaviors by Glutamatergic Neurons in the Ventrolateral Periaqueductal Gray and the Analgesic and Anxiolytic Effects of Electroacupuncture.
Xixiao Zhu, Chi Zhang, Yuxin Hu, Yifang Wang, Siqi Xiao, Boyu Liu, Jinggen Liu, Boyi Liu

eNeuro· August 2024

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Glutamatergic neurons in ventral pallidum modulate heroin addiction via epithalamic innervation in rats.
Ruo-Song Chen, Jing Liu, Yu-Jun Wang, Kuan Ning, Jing-Gen Liu, Zhi-Qiang Liu

Acta Pharmacol Sin· May 2024

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Discovery of an Ortho-Substituted -Cyclopropylmethyl-7α-phenyl-6,14-ethano-tetrahydronorthebaine Derivative as a Selective and Potent Kappa Opioid Receptor Agonist with Subsided Sedative Effect.
Zixiang Li, Rufeng Ye, Qian He, Jiashuo Lu, Yanting Sun, Xiaoning Liu, Jinggen Liu

J Med Chem· May 2024

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A neural circuit associated with anxiety-like behaviors induced by chronic inflammatory pain and the anxiolytic effects of electroacupuncture.
Zemin Wu, Zui Shen, Yingling Xu, Shaozong Chen, Siqi Xiao, Boyi Liu, Jinggen Liu

CNS Neurosci Ther· April 2024

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Activation of Nrf2 antioxidant signaling alleviates gout arthritis pain and inflammation.
Danyi Zeng, Chengyu Yin, Huina Wei, Yuanyuan Li, Yunqin Yang, Jinggen Liu, Boyu Liu, Boyi Liu

Biomed Pharmacother· January 2024

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The Antidepressant Effect of Magnolol on Depression-Like Behavior of CORT-Treated Mice.
Chi Xu, Jiayu Ye, Yanting Sun, Xiujian Sun, Jing-Gen Liu

J Mol Neurosci· January 2024

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Projection-defined median raphe Pet subpopulations are diversely implicated in seizure.
Heming Cheng, Qiuwen Lou, Nanxi Lai, Liying Chen, Shuo Zhang, Jinggen Liu

Neurobiol Dis· December 2023

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Paraventricular nucleus-central amygdala oxytocinergic projection modulates pain-related anxiety-like behaviors in mice.
Yu-Jie Li, Wei-Jia Du, Rui Liu, Gui-Ying Zan, Bing-Lu Ye, Jing-Gen Liu, Zhi-Qiang Liu

CNS Neurosci Ther· November 2023

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The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology.
Yu-Jun Wang, Gui-Ying Zan, Cenglin Xu, Xue-Ping Li, Xuelian Shu, Jing-Gen Liu

Nat Commun· November 2023

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Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone.
Linghui Kong, Kuan Ning, Xiao Liu, Jiashuo Lu, Baiyu Chen, Jinggen Liu

Eur J Med Chem· October 2023

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Prelimbic cortex dynorphin/κ opioid receptor system modulates methamphetamine-induced cognitive impairment.
Ying-Jie Cheng, Ying-Zhi Deng, Di Deng, Man-Qing Wu, Jing-Rui Chai, Jing-Gen Liu

Addict Biol· September 2023

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