Publications by authors named "Jinxin Che"

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SARS-CoV-2 NSP14 inhibitor exhibits potent antiviral activity and reverses NSP14-driven host modulation.
Mengxin Luo, Jun Mo, Ziqiao Wang, Huimin Wei, Kexin Chen, Yongkang Chen, Weihao Chen, Yichen Xu, Jinxin Che

Nat Commun· November 2025

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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML).
Jun Mo, Yuxian Wang, Youlu Pan, Qitao Xiao, Jinyi Zhao, Jinxin Che

Eur J Med Chem· October 2025

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Discovery of pyrrolo[2,3-d]pyrimidine derivatives as novel FLT3/IRAK4 inhibitors.
Haibin Yuan, Yue Gao, Peipei Wang, Xiaowu Dong, Jia Li, Chenxi Wang, Jinxin Che

Eur J Med Chem· October 2025

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Discovery and characterization of sulfonamide derivatives as transcriptional enhanced associate domain (TEAD) inhibitors: a novel approach for targeting hepatocellular carcinoma.
Yang Lu, Jian Gao, Jun Mo, Qiuqiu Shi, Yu Guo, Haifeng Chen, Jinxin Che

Bioorg Chem· October 2025

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Recent Advances in Peptide Linkers for Antibody-Drug Conjugates.
Shaoting Li, Yu Guo, Jinxin Che, Haibin Dai, Xiaowu Dong

J Med Chem· October 2025

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Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma.
Xiaoli Yu, Xueyan Liao, Jingyu Zhang, Hanlin Wang, Xian Li, Jinxin Che

J Med Chem· October 2025

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Development of Dual FLT3 and CHK1 PROTACs for the Treatment of AML.
Xuanmin Lian, Yue Gao, Wenjing Du, Chengcheng Xu, Xiaowu Dong, Jinxin Che

J Med Chem· October 2025

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Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma.
Yuheng Jin, Xueyan Liao, Jingyu Zhang, Haiting Duan, Ran Xu, Jinxin Che

J Med Chem· October 2025

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Discovery of a ubiquitin-specific protease 10 inhibitor with high binding affinity promoting cell apoptosis via down-regulated CDK4 for the treatment of hepatocellular carcinoma.
Yang Lu, Wentao Wang, Cheng Yuan, Mengxin Luo, Peipei Wang, Jinxin Che

Bioorg Chem· August 2025

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Targeting Stat3 with conditional knockout or PROTAC technology alleviates renal injury by Limiting pyroptosis.
Ming-Lu Ji, Jia-Nan Wang, Ming-Fei Wu, Chuan-Hui Xu, Meng-Meng Zhang, Ying Chen, Xin Chen, Jin-Xin Che

EBioMedicine· June 2025

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Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation.
Mingfei Wu, Xinfei Mao, Yiquan Wu, Wentao Wang, Yuyuan Jin, Yong Chen, Jinxin Che

J Med Chem· June 2025

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Recent Advances in FLT3-Based Dual Inhibitors: A Promising Strategy for the Treatment of Acute Myeloid Leukemia.
Haibin Yuan, Jinxin Che, Tao Liu

Curr Med Chem· June 2025

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Preparation, characterization, and antifungal activity of (E)-2-octenal/β-cyclodextrin inclusion complex against the blue mold in citrus fruit caused by a prochloraz-resistant Penicillium italicum strain.
Yuwei Luo, Yonghua Zhang, Xiumei Chen, Jinxin Che, Nengguo Tao

J Appl Microbiol· May 2025

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Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC.
Jiexuan Chen, Mingfei Wu, Jun Mo, Ju Hong, Wei Wang, Sikang Chen, Chengliang Zhu, Jinxin Che

J Med Chem· April 2025

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Cuminaldehyde: a potent antifungal agent for managing postharvest blue mold disease in Citrus reticulata Blanco cv. Ponkan.
Dazhao Liu, Okwong Oketch Reymick, Yuwei Luo, Xin Chen, JinXin Che

World J Microbiol Biotechnol· April 2025

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Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides.
Gongruixue Zeng, Gaoya Xu, Lixin Gao, Xiaoli Zheng, Xinglong Chi, Jinxin Che

Bioorg Chem· March 2025

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Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function.
Yuheng Jin, Xuxin Qi, Xiaoli Yu, Xirui Cheng, Boya Chen, Jinxin Che

Acta Pharm Sin B· March 2025

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TransTACs: Transforming antibodies into targeted protein degraders.
Yu Guo, Jinxin Che, Xiaowu Dong

Acta Pharm Sin B· February 2025

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An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti-Solid Tumor Immunity.
Yuejun Yao, Mingfei Wu, Yanfang Wang, Ziyan Liao, Yinxian Yang, Jinxin Che

Adv Mater· January 2025

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Discovery of a potent PARP1 PROTAC as a chemosensitizer for the treatment of colorectal cancer.
Mingfei Wu, Yiming Jiang, Daoming Zhang, Yiquan Wu, Yuyuan Jin, Yong Chen, Jinxin Che

Eur J Med Chem· January 2025

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EvaluationMaster: A GUI Tool for Structure-Based Virtual Screening Evaluation Analysis and Decision-Making Support.
Zheyuan Shen, Roufen Chen, Jian Gao, Xinglong Chi, Qingnan Zhang, Jinxin Che

J Chem Inf Model· January 2025

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PPI-CoAttNet: A Web Server for Protein-Protein Interaction Tasks Using a Coattention Model.
Qingyu Bian, Zheyuan Shen, Jian Gao, Liteng Shen, Yang Lu, Roufen Chen, Jinxin Che

J Chem Inf Model· January 2025

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DiPTAC: A degradation platform directly targeting proteasome.
Yutong Tu, Qian Yu, Mengna Li, Lixin Gao, Jialuo Mao, Jinxin Che

Acta Pharm Sin B· January 2025

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Discovery of a Novel Non-invasive AR PROTAC Degrader for the Topical Treatment of Androgenetic Alopecia.
Xinfei Mao, Weitong Hu, Mingfei Wu, Yuyuan Jin, Jingyi Zhao, Jinxin Che

J Med Chem· December 2024

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Author Correction: Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.
Chengyu Shi, Ying Wang, Minjie Wu, Yu Chen, Fangzhou Liu, Chenghao Pan, Jinxin Che

Nat Commun· December 2024

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