Publications by authors named "Job de Lange"

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Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy.
Raffaella Bonavita, Antonello Prodomo, Giuseppe Cortone, Fulvia Vitale, Marcello Germoglio, Job de Lange

Autophagy· November 2025

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Generation and characterization of two isogenic induced pluripotent stem cell lines from a young female with microcephaly carrying a compound heterozygous mutation in BUB1 gene.
Anita Ferreira, Sofia M Calado, Xavier Jorge, Job de Lange, Sara Carvalhal

Stem Cell Res· December 2024

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CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin.
Janne J M van Schie, Klaas de Lint, Thom M Molenaar, Macarena Moronta Gines, Jesper A Balk, Job de Lange

Nucleic Acids Res· October 2023

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MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC.
Janne Jm van Schie, Klaas de Lint, Govind M Pai, Martin A Rooimans, Rob Mf Wolthuis, Job de Lange

Life Sci Alliance· February 2023

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ShrinkCRISPR: a flexible method for differential fitness analysis of CRISPR-Cas9 screen data.
Renaud L M Tissier, Janne J M van Schie, Rob M F Wolthuis, Job de Lange, Renée de Menezes

BMC Bioinformatics· February 2023

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The future of CRISPR gene editing according to plant scientists.
Job de Lange, Lawton Lanier Nalley, Wei Yang, Aaron Shew, Hans de Steur

iScience· September 2022

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Biallelic mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.
Sara Carvalhal, Ingrid Bader, Martin A Rooimans, Anneke B Oostra, Jesper A Balk, Job de Lange

Sci Adv· January 2022

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The Interplay of Cohesin and the Replisome at Processive and Stressed DNA Replication Forks.
Janne J M van Schie, Job de Lange

Cells· December 2021

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Genomic integrity and mitochondrial metabolism defects in Warsaw syndrome cells: a comparison with Fanconi anemia.
Roberta Bottega, Silvia Ravera, Luisa M R Napolitano, Viviana Chiappetta, Nicoletta Zini, Job de Lange

J Cell Physiol· August 2021

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ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation.
Yana van der Weegen, Klaas de Lint, Diana van den Heuvel, Yuka Nakazawa, Tycho E T Mevissen, Job de Lange

Nat Cell Biol· June 2021

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Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion.
Janne J M van Schie, Atiq Faramarz, Jesper A Balk, Grant S Stewart, Erika Cantelli, Job de Lange

Nat Commun· August 2020

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Non-redundant roles in sister chromatid cohesion of the DNA helicase DDX11 and the SMC3 acetyl transferases ESCO1 and ESCO2.
Atiq Faramarz, Jesper A Balk, Janne J M van Schie, Anneke B Oostra, Cherien A Ghandour, Job de Lange

PLoS One· March 2020

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WAPL-Dependent Repair of Damaged DNA Replication Forks Underlies Oncogene-Induced Loss of Sister Chromatid Cohesion.
Bente Benedict, Janne J M van Schie, Anneke B Oostra, Jesper A Balk, Rob M F Wolthuis, Job de Lange

Dev Cell· March 2020

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Defective sister chromatid cohesion is synthetically lethal with impaired APC/C function.
Job de Lange, Atiq Faramarz, Anneke B Oostra, Renee X de Menezes, Ida H van der Meulen

Nat Commun· October 2015

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High levels of Hdmx promote cell growth in a subset of uveal melanomas.
Job de Lange, Amina Fas Teunisse, Matty Verlaan-de Vries, Kirsten Lodder, Suzanne Lam

Am J Cancer Res· October 2012

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MDM4 is a key therapeutic target in cutaneous melanoma.
Agnieszka Gembarska, Flavie Luciani, Clare Fedele, Elisabeth A Russell, Michael Dewaele, Job de Lange

Nat Med· August 2012

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Functional analysis of two inhibitor of apoptosis (iap) orthologs from Helicoverpa armigera nucleopolyhedrovirus.
Changyong Liang, Job de Lange, Xinwen Chen, Monique M van Oers, Just M Vlak

Virus Res· April 2012

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Oncogenic functions of hMDMX in in vitro transformation of primary human fibroblasts and embryonic retinoblasts.
Kristiaan Lenos, Job de Lange, Amina F A S Teunisse, Kirsten Lodder, Matty Verlaan-de Vries

Mol Cancer· September 2011

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HDMX-L is expressed from a functional p53-responsive promoter in the first intron of the HDMX gene and participates in an autoregulatory feedback loop to control p53 activity.
Anna Phillips, Amina Teunisse, Suzanne Lam, Kirsten Lodder, Matthew Darley, Job de Lange

J Biol Chem· September 2010

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