Publications by authors named "Jobin Varkey"

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TDP43 and huntingtin Exon-1 undergo a conformationally specific interaction that strongly alters the fibril formation of both proteins.
Gincy George, Anakha Ajayan, Jobin Varkey, Nitin K Pandey, Jeannie Chen

J Biol Chem· September 2024

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Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.
Axel Montagne, Angeliki M Nikolakopoulou, Zhen Zhao, Abhay P Sagare, Gabriel Si, Jobin Varkey

Nat Med· April 2024

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Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1.
Nitin K Pandey, Jobin Varkey, Anakha Ajayan, Gincy George, Jeannie Chen

J Biol Chem· January 2024

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Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction.
Jose M Bravo-Arredondo, Rajashree Venkataraman, Jobin Varkey, Jose Mario Isas, Alan J Situ

J Biol Chem· April 2023

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An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles.
Jobin Varkey, Jiantao Zhang, Junghyun Kim, Gincy George, Guijuan He

Viruses· December 2020

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Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils.
Alexander S Falk, José M Bravo-Arredondo, Jobin Varkey, Sayuri Pacheco, Ralf Langen

Biophys J· November 2020

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Gene co-expression network analysis for identifying genetic markers in Parkinson's disease - a three-way comparative approach.
Gincy George, Sachidanand Singh, Sowmya Bekshe Lokappa, Jobin Varkey

Genomics· July 2019

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E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity.
Matteo Rovere, Alex E Powers, Haiyang Jiang, Julia C Pitino, Luis Fonseca-Ornelas, Jobin Varkey

J Biol Chem· June 2019

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Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes.
Gincy George, Snijesh Valiya Parambath, Sowmya Bekshe Lokappa, Jobin Varkey

Gene· May 2019

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Membranes as modulators of amyloid protein misfolding and target of toxicity.
Anoop Rawat, Ralf Langen, Jobin Varkey

Biochim Biophys Acta Biomembr· September 2018

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Pericyte degeneration causes white matter dysfunction in the mouse central nervous system.
Axel Montagne, Angeliki M Nikolakopoulou, Zhen Zhao, Abhay P Sagare, Gabriel Si, Jobin Varkey

Nat Med· March 2018

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Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR.
Jobin Varkey, Ralf Langen

J Magn Reson· July 2017

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α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils.
Altaira D Dearborn, Joseph S Wall, Naiqian Cheng, J Bernard Heymann, Andrey V Kajava, Jobin Varkey

J Biol Chem· January 2016

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Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation.
Sujit Basak, G V R Krishna Prasad, Jobin Varkey, Krishnananda Chattopadhyay

ACS Chem Neurosci· February 2015

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Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding.
Ying Lai, Sunae Kim, Jobin Varkey, Xiaochu Lou, Jae-Kyun Song

Biochemistry· June 2014

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Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces.
Chi-Yuan Cheng, Jobin Varkey, Mark R Ambroso, Ralf Langen, Songi Han

Proc Natl Acad Sci U S A· October 2013

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α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles.
Jobin Varkey, Naoko Mizuno, Balachandra G Hegde, Naiqian Cheng, Alasdair C Steven

J Biol Chem· June 2013

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Rational design of potent domain antibody inhibitors of amyloid fibril assembly.
Ali Reza A Ladiwala, Moumita Bhattacharya, Joseph M Perchiacca, Ping Cao, Daniel P Raleigh, Jobin Varkey

Proc Natl Acad Sci U S A· December 2012

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Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation.
Naoko Mizuno, Jobin Varkey, Natalie C Kegulian, Balachandra G Hegde, Naiqian Cheng

J Biol Chem· August 2012

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Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.
Franziska Meier, Tharindumala Abeywardana, Abhinav Dhall, Nicholas P Marotta, Jobin Varkey

J Am Chem Soc· March 2012

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Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins.
Jobin Varkey, Jose Mario Isas, Naoko Mizuno, Martin Borch Jensen, Vikram Kjøller Bhatia

J Biol Chem· October 2010

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Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins.
Jobin Varkey, Shashi Singh, Ramakrishnan Nagaraj

Peptides· November 2006

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Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines.
Jobin Varkey, Ramakrishnan Nagaraj

Antimicrob Agents Chemother· November 2005

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