Publications by authors named "Joe Patel"

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CFT1946 is an Orally Available Brain-Penetrant BRAFV600-Mutant Degrader that Overcomes BRAF Inhibitor Resistance.
Bridget T Kreger, Yanke Liang, Nicole M Reilly, Meghan E Spears, William A Scott, Joe Patel

Cancer Res· October 2025

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Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Neil P Grimster, Lakshmaiah Gingipalli, Amber Balazs, Bernard Barlaam, Scott Boiko, Joe Patel

Bioorg Med Chem Lett· July 2023

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Correction to "Discovery of a Thiadiazole-Pyridazine-Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models".
M Raymond V Finlay, Mark Anderton, Andrew Bailey, Scott Boyd, Joanna Brookfield, Joe Patel

J Med Chem· July 2023

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Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.
Jon J Winter-Holt, Catherine Bardelle, Elisabetta Chiarparin, Ian L Dale, Paul R J Davey, Joe Patel

J Med Chem· February 2022

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Structural Characterization of Degrader-Induced Ternary Complexes Using Hydrogen-Deuterium Exchange Mass Spectrometry and Computational Modeling: Implications for Structure-Based Design.
Scott J Eron, Hongwei Huang, Roman V Agafonov, Mark E Fitzgerald, Joe Patel

ACS Chem Biol· November 2021

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Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Neil P Grimster, Lakshmaiah Gingipalli, Bernard Barlaam, Qibin Su, XiaoLan Zheng, Joe Patel

Bioorg Med Chem Lett· October 2020

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Identification of a novel series of azabenzimidazole-derived inhibitors of spleen tyrosine kinase.
Sameer P Kawatkar, Bernard Barlaam, Paul Kemmitt, Iain Simpson, David Watson, Joe Patel

Bioorg Med Chem Lett· September 2020

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Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
Xavier Guillory, Madita Wolter, Seppe Leysen, João Filipe Neves, Ave Kuusk, Joe Patel

J Med Chem· July 2020

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Discovery and optimization of covalent Bcl-xL antagonists.
Herschel Mukherjee, Nancy Su, Matthew A Belmonte, David Hargreaves, Joe Patel

Bioorg Med Chem Lett· December 2019

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Potent and selective bivalent inhibitors of BET bromodomains.
Michael J Waring, Huawei Chen, Alfred A Rabow, Graeme Walker, Romel Bobby, Joe Patel

Nat Chem Biol· December 2016

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Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153).
Robert H Bradbury, Rowena Callis, Gregory R Carr, Huawei Chen, Edwin Clark, Anil Patel, Joe Patel

J Med Chem· September 2016

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An improved model for fragment-based lead generation at AstraZeneca.
Nathan Fuller, Loredana Spadola, Scott Cowen, Joe Patel, Heike Schönherr

Drug Discov Today· August 2016

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Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.
Jon J G Winter, Malcolm Anderson, Kevin Blades, Claire Brassington, Alexander L Breeze, S Joe Patel

J Med Chem· March 2015

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