Publications by authors named "Johan Lantto"

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First-in-human trial exploring safety, antitumor activity, and pharmacokinetics of Sym013, a recombinant pan-HER antibody mixture, in advanced epithelial malignancies.
Jordan Berlin, Anthony W Tolcher, Cliff Ding, Jennifer G Whisenant, Ivan D Horak, Johan Lantto

Invest New Drugs· June 2022

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A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge.
Scott Parker, June D'Angelo, R Mark Buller, Donald F Smee, Johan Lantto

Antiviral Res· November 2021

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CD4 and CD8a PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models.
Lotte K Kristensen, Camilla Fröhlich, Camilla Christensen, Maria C Melander, Thomas T Poulsen, Johan Lantto

Theranostics· August 2020

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Simultaneous targeting of HER family pro-survival signaling with Pan-HER antibody mixture is highly effective in TNBC: a preclinical trial with PDXs.
Tejaswini P Reddy, Dong S Choi, Ann C Anselme, Wei Qian, Wen Chen, Johan Lantto

Breast Cancer Res· May 2020

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Sym021, a promising anti-PD1 clinical candidate antibody derived from a new chicken antibody discovery platform.
Torben Gjetting, Monika Gad, Camilla Fröhlich, Trine Lindsted, Maria C Melander, Johan Lantto

MAbs· January 2020

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Simultaneous Targeting of Two Distinct Epitopes on MET Effectively Inhibits MET- and HGF-Driven Tumor Growth by Multiple Mechanisms.
Michael M Grandal, Serhiy Havrylov, Thomas T Poulsen, Klaus Koefoed, Anna Dahlman, Johan Lantto

Mol Cancer Ther· December 2017

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An ERBB1-3 Neutralizing Antibody Mixture With High Activity Against Drug-Resistant HER2+ Breast Cancers With ERBB Ligand Overexpression.
Luis J Schwarz, Katherine E Hutchinson, Brent N Rexer, Mónica Valeria Estrada, Paula I Gonzalez Ericsson, Johan Lantto

J Natl Cancer Inst· November 2017

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Sym015: A Highly Efficacious Antibody Mixture against -Amplified Tumors.
Thomas Tuxen Poulsen, Michael Monrad Grandal, Niels Jørgen Østergaard Skartved, Rikke Hald, Lene Alifrangis, Johan Lantto

Clin Cancer Res· October 2017

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Pan-HER-An antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand-induced EGFR homo- and heterodimers.
Sofie Ellebaek, Susanne Brix, Michael Grandal, Johan Lantto, Ivan D Horak

Int J Cancer· November 2016

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Targeting the HER Family with Pan-HER Effectively Overcomes Resistance to Cetuximab.
Mari Iida, Harsh Bahrar, Toni M Brand, Hannah E Pearson, John P Coan, Johan Lantto

Mol Cancer Ther· September 2016

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Pan-HER Inhibitor Augments Radiation Response in Human Lung and Head and Neck Cancer Models.
David M Francis, Shyhmin Huang, Eric A Armstrong, Lauryn R Werner, Craig Hullett, Johan Lantto

Clin Cancer Res· February 2016

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In vivo imaging of therapy response to a novel pan-HER antibody mixture using FDG and FLT positron emission tomography.
Carsten H Nielsen, Mette M Jensen, Lotte K Kristensen, Anna Dahlman, Camilla Fröhlich, Johan Lantto

Oncotarget· November 2015

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The genomic landscape of response to EGFR blockade in colorectal cancer.
Andrea Bertotti, Eniko Papp, Siân Jones, Vilmos Adleff, Valsamo Anagnostou, Johan Lantto

Nature· October 2015

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Pan-HER, an Antibody Mixture Simultaneously Targeting EGFR, HER2, and HER3, Effectively Overcomes Tumor Heterogeneity and Plasticity.
Helle J Jacobsen, Thomas T Poulsen, Anna Dahlman, Ida Kjær, Klaus Koefoed, Johan Lantto

Clin Cancer Res· September 2015

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Targeting Three Distinct HER2 Domains with a Recombinant Antibody Mixture Overcomes Trastuzumab Resistance.
Mikkel W Pedersen, Helle J Jacobsen, Klaus Koefoed, Anna Dahlman, Ida Kjær, Johan Lantto

Mol Cancer Ther· March 2015

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Passive immunotherapies protect WRvFire and IHD-J-Luc vaccinia virus-infected mice from lethality by reducing viral loads in the upper respiratory tract and internal organs.
Marina Zaitseva, Senta M Kapnick, Clement A Meseda, Elisabeth Shotwell, Lisa R King, Johan Lantto

J Virol· September 2011

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Capturing the natural diversity of the human antibody response against vaccinia virus.
Johan Lantto, Margit Haahr Hansen, Søren Kofoed Rasmussen, Lucilla Steinaa, Tine R Poulsen

J Virol· February 2011

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Human antibody repertoires.
Per-Johan Meijer, Lars S Nielsen, Johan Lantto, Allan Jensen

Methods Mol Biol· April 2009

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Clonal repertoire diversification of a neutralizing cytomegalovirus glycoprotein B-specific antibody results in variants with diverse anti-viral properties.
Yvelise Barrios, Susanne Knör, Johan Lantto, Michael Mach, Mats Ohlin

Mol Immunol· February 2007

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Recombinant human polyclonal antibodies: A new class of therapeutic antibodies against viral infections.
Søren Bregenholt, Allan Jensen, Johan Lantto, Sara Hyldig, John S Haurum

Curr Pharm Des· August 2006

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Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing.
Per-Johan Meijer, Peter S Andersen, Margit Haahr Hansen, Lucilla Steinaa, Allan Jensen, Johan Lantto

J Mol Biol· May 2006

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A focused antibody library for improved hapten recognition.
Helena Persson, Johan Lantto, Mats Ohlin

J Mol Biol· March 2006

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Subtle sequence differences in a tumour-associated peptide epitope translate into major changes in antigenicity.
Jonas Persson, Johan Lantto, Torbjörn Drakenberg, Mats Ohlin

Mol Immunol· July 2005

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Binding characteristics determine the neutralizing potential of antibody fragments specific for antigenic domain 2 on glycoprotein B of human cytomegalovirus.
Johan Lantto, Jean M Fletcher, Mats Ohlin

Virology· January 2003

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Functional consequences of insertions and deletions in the complementarity-determining regions of human antibodies.
Johan Lantto, Mats Ohlin

J Biol Chem· November 2002

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