Publications by authors named "John A Chaddock"

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Engineering Botulinum Toxins to Improve and Expand Targeting and SNARE Cleavage Activity.
Elena Fonfria, Mark Elliott, Matthew Beard, John A Chaddock, Johannes Krupp

Toxins (Basel)· July 2018

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Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors.
Geoffrey Masuyer, Jonathan R Davies, Kevin Moore, John A Chaddock, K Ravi Acharya

Sci Rep· September 2015

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Engineered botulinum neurotoxins as new therapeutics.
Geoffrey Masuyer, John A Chaddock, Keith A Foster, K Ravi Acharya

Annu Rev Pharmacol Toxicol· September 2014

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Engineering botulinum neurotoxin domains for activation by toxin light chain.
Patrick R Stancombe, Geoffrey Masuyer, Ian Birch-Machin, Matthew Beard, Keith A Foster, John A Chaddock

FEBS J· February 2012

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Structures of engineered Clostridium botulinum neurotoxin derivatives.
Geoffrey Masuyer, Patrick Stancombe, John A Chaddock, K Ravi Acharya

Acta Crystallogr Sect F Struct Biol Cryst Commun· December 2011

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Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B.
Geoffrey Masuyer, Matthew Beard, Verity A Cadd, John A Chaddock, K Ravi Acharya

J Struct Biol· April 2011

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Engineering toxins for 21st century therapies.
John A Chaddock, K Ravi Acharya

FEBS J· April 2011

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Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A.
Geoffrey Masuyer, Nethaji Thiyagarajan, Peter L James, Philip M H Marks, John A Chaddock

Biochem Biophys Res Commun· March 2009

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Botulinum neurotoxin A and neurotoxin E cleavage products of synaptosome-associated protein of 25 kd exhibit distinct actions on pancreatic islet beta-cell Kv2.1 channel gating.
Yan He, Chadwick L Elias, Ya-Chi Huang, Xiaodong Gao, Yuk-Man Leung, John A Chaddock

Pancreas· January 2008

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Preparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applications.
J Mark Sutton, Jonathan Wayne, Anthony Scott-Tucker, Susan M O'Brien, Philip M H Marks, John A Chaddock

Protein Expr Purif· March 2005

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Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose.
Kathryn Turton, Ramanathan Natesh, Nethaji Thiyagarajan, John A Chaddock, K Ravi Acharya

Glycobiology· October 2004

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Novel application of an in vitro technique to the detection and quantification of botulinum neurotoxin antibodies.
Yper H J Hall, John A Chaddock, Hilary J Moulsdale, Elizabeth R Kirby, Frances C G Alexander

J Immunol Methods· May 2004

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Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.
John A Chaddock, John R Purkiss, Frances C G Alexander, Sarah Doward, Sarah J Fooks

Mov Disord· March 2004

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Isolation of the gene and large-scale expression and purification of recombinant Erythrina cristagalli lectin.
Patrick R Stancombe, Frances C G Alexander, Roger Ling, Mary A Matheson, Clifford C Shone, John A Chaddock

Protein Expr Purif· August 2003

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Botulinum and tetanus neurotoxins: structure, function and therapeutic utility.
Kathryn Turton, John A Chaddock, K Ravi Acharya

Trends Biochem Sci· November 2002

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Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin.
Michael J Duggan, Conrad P Quinn, John A Chaddock, John R Purkiss, Frances C G Alexander

J Biol Chem· September 2002

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Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A.
John A Chaddock, Michael H Herbert, Roger J Ling, Frances C G Alexander, Sarah J Fooks

Protein Expr Purif· July 2002

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