Publications by authors named "John Bruning"

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Multimodal bHLH-PAS DNA binding controls specificity and drives obesity.
David C Bersten, Daniel P McDougal, Adrienne E Sullivan, Alexis Gerassimou, James Breen, John B Bruning

Nucleic Acids Res· January 2026

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Structural determinants of non-covalent PPARγ inverse agonism and their therapeutic implications.
Kuang-Ting Kuo, Bilel Bdiri, Yuanjun He, Ruben D Garcia-Ordonez, Daniel P McDougal, John B Bruning

Nat Commun· December 2025

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A ternary switch model governing ERα ligand binding domain conformation.
Daniel P McDougal, Jordan L Pederick, Scott J Novick, Blagojce Jovcevski, Annmaree K Warrender, John B Bruning

Nat Commun· November 2025

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Protein disulfide isomerases regulate androgen receptor stability and promote prostate cancer cell growth and survival.
Jianling Xie, Kaikai Shen, Wenken Liang, Zijian Kuang, Raj K Shrestha, John B Bruning

Proc Natl Acad Sci U S A· October 2025

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Structural comparison of androstenediol recognition by the human estrogen receptor ligand binding domains.
Jordan L Pederick, John B Bruning

Mol Cell Endocrinol· September 2025

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Structural constraints prevent a bat norovirus from binding to histo-blood group antigen co-factors.
Dayna L Holroyd, John B Bruning, Mark von Itzstein, Grant S Hansman

J Virol· September 2025

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Structural insights into a plant-conserved DHFR-TS reveal a selective herbicide target.
Joel Haywood, Karen J Breese, Daniel P McDougal, Callum Verdonk, Abigail Partridge, John B Bruning

Mol Plant· August 2025

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Activity of STAMP inhibitors in rearranged acute lymphoblastic leukemia is dependent on the Abl2 SH3 domain.
Elias Lagonik, Elyse C Page, John B Bruning, Laura N Eadie, Susan L Heatley

Blood Neoplasia· August 2025

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Evolutionary insights into the selectivity of sterol oxidising cytochrome P450 enzymes based on ancestral sequence reconstruction.
Daniel Z Doherty, James J De Voss, John B Bruning, Stephen G Bell

Chem Sci· June 2025

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Antigenic structural analysis of bat and human norovirus protruding (P) domains.
Dayna L Holroyd, Akhil Kumar, Eduardo Vasquez, Veronika Masic, Mark von Itzstein, John B Bruning

J Virol· April 2025

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Functional and structural characterization of Staphylococcus aureus N-acetylglucosamine 1-phosphate uridyltransferase (GlmU) reveals a redox-sensitive acetyltransferase activity.
Jordan L Pederick, Akhil Kumar, Tara L Pukala, John B Bruning

Protein Sci· April 2025

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Identification of Cysteine Metabolism Regulator (CymR)-Derived Pentapeptides as Nanomolar Inhibitors of -Acetyl-l-serine Sulfhydrylase (CysK).
Jordan L Pederick, Bethiney C Vandborg, Amir George, Hannah Bovermann, Jeffrey M Boyd, John B Bruning

ACS Infect Dis· January 2025

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Identification of cysteine metabolism regulator (CymR)-derived pentapeptides as nanomolar inhibitors of O-acetyl-ʟ-serine sulfhydrylase (CysK).
Jordan L Pederick, Bethiney C Vandborg, Amir George, Hannah Bovermann, Jeffrey M Boyd, John B Bruning

bioRxiv· September 2024

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Biochemical and characterization of glycosyltransferases from red sweet cherry ( L.) reveals their broad specificity toward phenolic substrates.
Daniel Clayton-Cuch, Long Yu, Daniel McDougal, Crista A Burbidge, John B Bruning

Food Chem (Oxf)· July 2024

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Selective -Hydroxyketone Formation and Subsequent C-C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes.
Joel H Z Lee, Tom Coleman, Mark A Mclean, Matthew N Podgorski, Eva F Hayball, John B Bruning

ACS Catal· June 2024

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Structural determination and characterisation of the CYP105Q4 cytochrome P450 enzyme from Mycobacterium marinum.
Hebatalla Mohamed, Stella A Child, Daniel Z Doherty, John B Bruning, Stephen G Bell

Arch Biochem Biophys· April 2024

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An In Crystallo Reaction with an Engineered Cytochrome P450 Peroxygenase.
Joel H Z Lee, John B Bruning, Stephen G Bell

Chemistry· February 2024

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Comparative functional and structural analysis of Pseudomonas aeruginosa d-alanine-d-alanine ligase isoforms as prospective antibiotic targets.
Jordan L Pederick, Jessica C Woolman, John B Bruning

FEBS J· December 2023

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Characterisation of the heme aqua-ligand coordination environment in an engineered peroxygenase cytochrome P450 variant.
Matthew N Podgorski, Joel H Z Lee, Joshua S Harbort, Giang T H Nguyen, Daniel Z Doherty, John B Bruning

J Inorg Biochem· December 2023

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Structure-guided design and synthesis of ATP-competitive N-acyl-substituted sulfamide d-alanine-d-alanine ligase inhibitors.
Rouven Becker, Jordan L Pederick, Edward G Dawes, John B Bruning, Andrew D Abell

Bioorg Med Chem· December 2023

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Towards a High-Affinity Peptidomimetic Targeting Proliferating Cell Nuclear Antigen from .
Bethiney C Vandborg, Aimee J Horsfall, Jordan L Pederick, Andrew D Abell, John B Bruning

J Fungi (Basel)· November 2023

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The Oxidation of Oxygen and Sulfur-Containing Heterocycles by Cytochrome P450 Enzymes.
Matthew N Podgorski, Angus B Keto, Tom Coleman, John B Bruning, James J De Voss

Chemistry· September 2023

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Fortuitous Compound Degradation Produces a Tractable Hit against Dethiobiotin Synthetase: A Cautionary Tale of What Goes In Does Not Always Come Out.
Wanisa Salaemae, Andrew P Thompson, Birgit I Gaiser, Kwang Jun Lee, Michael T Huxley, John B Bruning

ACS Chem Biol· September 2023

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Designing Fluorescent Nuclear Permeable Peptidomimetics to Target Proliferating Cell Nuclear Antigen.
Aimee J Horsfall, Theresa Chav, Jordan L Pederick, Zoya Kikhtyak, Bethiney C Vandborg, John B Bruning

J Med Chem· August 2023

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warpDOCK: Large-Scale Virtual Drug Discovery Using Cloud Infrastructure.
Daniel P McDougal, Harinda Rajapaksha, Jordan L Pederick, John B Bruning

ACS Omega· August 2023

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