Publications by authors named "John Chorba"

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TOMM40 regulates hepatocellular and plasma lipid metabolism via an LXR-dependent pathway.
Neil V Yang, Justin Y Chao, Kelly A Garton, Tommy Tran, Sarah M King, John S Chorba

Mol Metab· December 2024

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Aligning public and institutional incentives to advance biomedical research.
John S Chorba

Nat Cardiovasc Res· January 2024

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The Silent Threat: Bartonella quintana Endocarditis Unveiling Heart Failure and Severe Pulmonary Hypertension.
Daniel Boctor, Brian Bakke, John S Chorba

Am J Case Rep· December 2023

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Deep Learning Algorithms to Detect Murmurs Associated With Structural Heart Disease.
John Prince, John Maidens, Spencer Kieu, Caroline Currie, Daniel Barbosa, John Chorba

J Am Heart Assoc· October 2023

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Heparin Does Not Regulate Circulating Human PCSK9 (Proprotein Convertase Subtilisin-Kexin Type 9) in a General Population-Brief Report.
Vivian Q Xia, Chui Mei Ong, Lucas S Zier, John S MacGregor, Alan H B Wu, John S Chorba

Arterioscler Thromb Vasc Biol· February 2023

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Rapid Multiplexed Flow Cytometric Validation of CRISPRi sgRNAs in Tissue Culture.
John S Chorba, Vivian Q Xia, Geoffrey A Smith, Arun Padmanabhan

Bio Protoc· January 2023

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Cold shock domain-containing protein E1 is a posttranscriptional regulator of the LDL receptor.
Geoffrey A Smith, Arun Padmanabhan, Bryan H Lau, Akhil Pampana, Li Li, John S Chorba

Sci Transl Med· September 2022

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Physical Maneuvers and Recent Tools to Break the Silence of Clinically Undetectable Heart Sounds.
John Maidens, John S Chorba, James D Thomas

JAMA Intern Med· May 2022

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Deep Learning Algorithm for Automated Cardiac Murmur Detection via a Digital Stethoscope Platform.
John S Chorba, Avi M Shapiro, Le Le, John Maidens, John Prince

J Am Heart Assoc· May 2021

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A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, John S Chorba

bioRxiv· March 2020

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Cell-associated heparin-like molecules modulate the ability of LDL to regulate PCSK9 uptake.
Adri M Galvan, John S Chorba

J Lipid Res· January 2019

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A High-Throughput Luciferase Assay to Evaluate Proteolysis of the Single-Turnover Protease PCSK9.
John S Chorba, Adri M Galvan, Kevan M Shokat

J Vis Exp· August 2018

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Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.
John S Chorba, Adri M Galvan, Kevan M Shokat

J Biol Chem· May 2018

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Stepwise processing analyses of the single-turnover PCSK9 protease reveal its substrate sequence specificity and link clinical genotype to lipid phenotype.
John S Chorba, Adri M Galvan, Kevan M Shokat

J Biol Chem· February 2018

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An Educational and Administrative Intervention to Promote Rational Laboratory Test Ordering on an Academic General Medicine Service.
Bradley M Wertheim, Andrew J Aguirre, Roby P Bhattacharyya, John Chorba, Ashutosh P Jadhav

Am J Med· January 2017

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The proprotein convertase subtilisin/kexin type 9 (PCSK9) active site and cleavage sequence differentially regulate protein secretion from proteolysis.
John S Chorba, Kevan M Shokat

J Biol Chem· October 2014

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Brain natriuretic peptide predicts functional outcome in ischemic stroke.
Natalia S Rost, Alessandro Biffi, Lisa Cloonan, John Chorba, Peter Kelly

Stroke· February 2012

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Sustained ventricular fibrillation in a conscious patient.
Thomas A Dewland, John S Chorba, Nora Goldschlager, Gregory M Marcus

Arch Intern Med· June 2011

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Vesicular stomatitis viruses resistant to the methylase inhibitor sinefungin upregulate RNA synthesis and reveal mutations that affect mRNA cap methylation.
Jianrong Li, John S Chorba, Sean P J Whelan

J Virol· April 2007

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Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.
Scott H Watterson, Marianne Carlsen, T G Murali Dhar, Zhongqi Shen, William J Pitts, John Chorba

Bioorg Med Chem Lett· February 2003

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Quinolone-based IMPDH inhibitors: introduction of basic residues on ring D and SAR of the corresponding mono, di and benzofused analogues.
T G Murali Dhar, Scott H Watterson, Ping Chen, Zhongqi Shen, Henry H Gu, John Chorba

Bioorg Med Chem Lett· February 2003

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