Publications by authors named "John D Buynak"

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D
Dual mechanism of the OXA-23 carbapenemase inhibition by the carbapenem NA-1-157.
Marta Toth, Nichole K Stewart, Pojun Quan, Md Mahbub Kabir Khan, Jonathan Cox, John D Buynak

Antimicrob Agents Chemother· October 2025

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Novel C5α-substituted carbapenems enhance killing via selective target binding and reduced hydrolysis by Bla.
Eunjeong Shin, Magdalena A Taracila, Pojun Quan, Md Mahbub Kabir Khan, Jonathan Cox, John D Buynak

Antimicrob Agents Chemother· August 2025

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Decarboxylation of the Catalytic Lysine Residue by the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the OXA-58 Carbapenemase.
Marta Toth, Nichole K Stewart, Ailiena O Maggiolo, Pojun Quan, Md Mahbub Kabir Khan, John D Buynak

ACS Infect Dis· December 2024

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Restricted Rotational Flexibility of the C5α-Methyl-Substituted Carbapenem NA-1-157 Leads to Potent Inhibition of the GES-5 Carbapenemase.
Nichole K Stewart, Marta Toth, Pojun Quan, Michael Beer, John D Buynak

ACS Infect Dis· April 2024

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The C5α-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against spp. Isolates Producing OXA-48-Type Carbapenemases.
Clyde A Smith, Nichole K Stewart, Marta Toth, Pojun Quan, John D Buynak

ACS Infect Dis· May 2023

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C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Carbapenemase OXA-23 by Impeding Deacylation.
Nichole K Stewart, Marta Toth, Maha A Alqurafi, Weirui Chai, Thu Q Nguyen, John D Buynak

mBio· June 2022

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Atypically Modified Carbapenem Antibiotics Display Improved Antimycobacterial Activity in the Absence of β-Lactamase Inhibitors.
Rashmi Gupta, Noora M S A Al-Kharji, Maha A Alqurafi, Thu Q Nguyen, Weirui Chai, John D Buynak

ACS Infect Dis· August 2021

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Activity of Imipenem, Meropenem, Cefepime, and Sulbactam in Combination with the β-Lactamase Inhibitor LN-1-255 against spp.
Cristina Lasarte-Monterrubio, Juan C Vázquez-Ucha, Maria Maneiro, Jorge Arca-Suárez, Isaac Alonso, John D Buynak

Antibiotics (Basel)· February 2021

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Therapeutic Efficacy of LN-1-255 in Combination with Imipenem in Severe Infection Caused by Carbapenem-Resistant Acinetobacter baumannii.
Juan Carlos Vázquez-Ucha, Marta Martínez-Guitián, María Maneiro, Kelly Conde-Pérez, Laura Álvarez-Fraga, John D Buynak

Antimicrob Agents Chemother· October 2019

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Virtual Screening and Experimental Testing of B1 Metallo-β-lactamase Inhibitors.
Joon S Kang, Antonia L Zhang, Mohammad Faheem, Charles J Zhang, Ni Ai, John D Buynak

J Chem Inf Model· September 2018

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LN-1-255, a penicillanic acid sulfone able to inhibit the class D carbapenemase OXA-48.
Juan A Vallejo, Marta Martínez-Guitián, Juan C Vázquez-Ucha, Concepción González-Bello, Margarita Poza, John D Buynak

J Antimicrob Chemother· August 2016

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Functionalizing the γ-Position of α-Diazo-β-ketoesters.
Thu Q Nguyen, Maha Alqurafi, Cash Edwards, Pauline Nguyen, Jean Kim, John D Buynak

Tetrahedron Lett· June 2016

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Meropenem and chromacef intermediates observed in IMP-25 metallo-β-lactamase-catalyzed hydrolysis.
Peter Oelschlaeger, Mahesh Aitha, Hao Yang, Joon S Kang, Antonia L Zhang, John D Buynak

Antimicrob Agents Chemother· July 2015

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Triethysilyl Enol Ethers in the Synthesis of Carbapenem Precursors.
Thu Q Nguyen, Weirui Chai, Jane Gu, Katie Cook, Eugene Kim, John D Buynak

Tetrahedron Lett· June 2015

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Detecting a quasi-stable imine species on the reaction pathway of SHV-1 β-lactamase and 6β-(hydroxymethyl)penicillanic acid sulfone.
Tao Che, Elizabeth A Rodkey, Christopher R Bethel, Sivaprakash Shanmugam, Zhe Ding, John D Buynak

Biochemistry· January 2015

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Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition.
Elizabeth A Rodkey, Marisa L Winkler, Christopher R Bethel, Sundar Ram Reddy Pagadala, John D Buynak

PLoS One· September 2014

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β-Lactamase inhibition by 7-alkylidenecephalosporin sulfones: allylic transposition and formation of an unprecedented stabilized acyl-enzyme.
Elizabeth A Rodkey, David C McLeod, Christopher R Bethel, Kerri M Smith, Yan Xu, John D Buynak

J Am Chem Soc· December 2013

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β-Lactamase inhibitors: a review of the patent literature (2010 - 2013).
John D Buynak

Expert Opin Ther Pat· November 2013

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Early insights into the interactions of different β-lactam antibiotics and β-lactamase inhibitors against soluble forms of Acinetobacter baumannii PBP1a and Acinetobacter sp. PBP3.
Krisztina M Papp-Wallace, Baui Senkfor, Julian Gatta, Weirui Chai, Magdalena A Taracila, John D Buynak

Antimicrob Agents Chemother· November 2012

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Carboxylation and decarboxylation of active site Lys 84 controls the activity of OXA-24 β-lactamase of Acinetobacter baumannii: Raman crystallographic and solution evidence.
Tao Che, Robert A Bonomo, Sivaprakash Shanmugam, Christopher R Bethel, Marianne Pusztai-Carey, John D Buynak

J Am Chem Soc· July 2012

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The importance of the trans-enamine intermediate as a β-lactamase inhibition strategy probed in inhibitor-resistant SHV β-lactamase variants.
Wei Ke, Elizabeth A Rodkey, Jared M Sampson, Marion J Skalweit, Anjaneyulu Sheri, John D Buynak

ChemMedChem· June 2012

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Crystal structures of KPC-2 β-lactamase in complex with 3-nitrophenyl boronic acid and the penam sulfone PSR-3-226.
Wei Ke, Christopher R Bethel, Krisztina M Papp-Wallace, Sundar Ram Reddy Pagadala, Micheal Nottingham, John D Buynak

Antimicrob Agents Chemother· May 2012

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Inactivation of a class A and a class C β-lactamase by 6β-(hydroxymethyl)penicillanic acid sulfone.
Krisztina M Papp-Wallace, Christopher R Bethel, Thomas D Gootz, Wenchi Shang, Justin Stroh, John D Buynak

Biochem Pharmacol· February 2012

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Ligand-dependent disorder of the Omega loop observed in extended-spectrum SHV-type beta-lactamase.
Jared M Sampson, Wei Ke, Christopher R Bethel, S R R Pagadala, Michael D Nottingham, John D Buynak

Antimicrob Agents Chemother· May 2011

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