Publications by authors named "John D Fryer"

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A glial circadian gene expression atlas reveals cell-type and disease-specific reprogramming in response to amyloid pathology or aging.
Patrick W Sheehan, Stuart B Fass, Darshan Sapkota, Sylvia Kang, Henry C Hollis, John D Fryer

Nat Neurosci· November 2025

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Intrahippocampally Injected Human Recombinant Clusterin Reduces Amyloid-β Aggregate Size in Cerebral Arteriole Walls of Clusterin Knockout Mice.
Alexandru Laslo, Tudor-Gabriel Boghițoiu, Laura Chinezu, Doina Manu, Adrian Dumitru Ivanescu, John D Fryer

Neuropathol Appl Neurobiol· October 2025

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Mapping medically relevant RNA isoform diversity in the aged human frontal cortex with deep long-read RNA-seq.
Bernardo Aguzzoli Heberle, J Anthony Brandon, Madeline L Page, Kayla A Nations, Ketsile I Dikobe, John D Fryer

Nat Biotechnol· April 2025

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Postmortem Interval Leads to Loss of Disease-Specific Signatures in Brain Tissue.
Kimberly C Olney, Katelin A Gibson, Mika P Cadiz, Negin Rahimzadeh, Vivek Swarup, John D Fryer

eNeuro· March 2025

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Distinct transcriptional alterations distinguish Lewy body disease from Alzheimer's disease.
Kimberly C Olney, Benjamin E Rabichow, Aleksandra M Wojtas, Michael DeTure, Pamela J McLean, John D Fryer

Brain· January 2025

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Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations.
Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, John D Fryer

J Exp Med· February 2024

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Commonly disrupted pathways in brain and kidney in a pig model of systemic endotoxemia.
Kimberly C Olney, Camila de Ávila, Kennedi T Todd, Lauren E Tallant, J Hudson Barnett, John D Fryer

J Neuroinflammation· January 2024

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Using deep long-read RNAseq in Alzheimer's disease brain to assess medical relevance of RNA isoform diversity.
Bernardo Aguzzoli Heberle, J Anthony Brandon, Madeline L Page, Kayla A Nations, Ketsile I Dikobe, John D Fryer

bioRxiv· December 2023

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Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer's disease.
Chia-Chen Liu, Na Wang, Yuanxin Chen, Yasuteru Inoue, Francis Shue, John D Fryer

Nat Immunol· November 2023

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Investigating the Pathogenic Interplay of Alpha-Synuclein, Tau, and Amyloid Beta in Lewy Body Dementia: Insights from Viral-Mediated Overexpression in Transgenic Mouse Models.
Melina J Lim, Suelen L Boschen, Aishe Kurti, Monica Castanedes Casey, Virginia R Phillips, John D Fryer

Biomedicines· October 2023

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Higher Levels of Stress and Neuropsychological Symptoms Are Associated With a High Nausea Profile in Patients With Cancer Receiving Chemotherapy.
Komal P Singh, Bruce A Cooper, Cindy S Tofthagen, John D Fryer, Parminder Singh

Oncol Nurs Forum· June 2023

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Biomaterial mediated simultaneous delivery of spermine and alpha ketoglutarate modulate metabolism and innate immune cell phenotype in sepsis mouse models.
Sahil Inamdar, Tina Tylek, Abhirami Thumsi, Abhirami P Suresh, Madhan Mohan Chandra Sekhar Jaggarapu, John D Fryer

Biomaterials· February 2023

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Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration.
Wei Shao, Tiffany W Todd, Yanwei Wu, Caroline Y Jones, Jimei Tong, John D Fryer

Science· October 2022

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Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function.
Chia-Chen Liu, Jing Zhao, Yuan Fu, Yasuteru Inoue, Yingxue Ren, John D Fryer

Nat Neurosci· August 2022

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Widespread choroid plexus contamination in sampling and profiling of brain tissue.
Kimberly C Olney, Kennedi T Todd, Praveen N Pallegar, Tanner D Jensen, Mika P Cadiz, John D Fryer

Mol Psychiatry· March 2022

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Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro.
Mika P Cadiz, Tanner D Jensen, Jonathon P Sens, Kuixi Zhu, Won-Min Song, John D Fryer

Mol Neurodegener· March 2022

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Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model.
Karen Jansen-West, Tiffany W Todd, Lillian M Daughrity, Mei Yue, Jimei Tong, John D Fryer

Front Cell Dev Biol· March 2022

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Estrous Cycle Modulation of Feeding and Relaxin-3/Rxfp3 mRNA Expression: Implications for Estradiol Action.
Camila de Ávila, Sandrine Chometton, Juliane Calvez, Geneviève Guèvremont, Alan Kania, John D Fryer

Neuroendocrinology· January 2022

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-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia.
Chia-Chen Liu, Melissa E Murray, Xia Li, Na Zhao, Na Wang, John D Fryer

Sci Transl Med· September 2021

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Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3.
Yuka Koike, Karen R Jansen-West, Rana Hanna Al-Shaikh, Yari Carlomagno, Yuping Song, John D Fryer

Parkinsonism Relat Disord· August 2021

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Loss of Tmem106b leads to cerebellum Purkinje cell death and motor deficits.
Rosa Rademakers, Alexandra M Nicholson, Yingxue Ren, Shunsuke Koga, Hung Phuoc Nguyen, John D Fryer

Brain Pathol· May 2021

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Long-read targeted sequencing uncovers clinicopathological associations for C9orf72-linked diseases.
Mariely DeJesus-Hernandez, Ross A Aleff, Jazmyne L Jackson, NiCole A Finch, Matthew C Baker, John D Fryer

Brain· May 2021

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Vascular ApoE4 Impairs Behavior by Modulating Gliovascular Function.
Yu Yamazaki, Chia-Chen Liu, Akari Yamazaki, Francis Shue, Yuka A Martens, John D Fryer

Neuron· February 2021

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Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer's disease neuropathology.
Fading Chen, Dan B Swartzlander, Anamitra Ghosh, John D Fryer, Baiping Wang

Mol Neurodegener· January 2021

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Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation.
Aleksandra M Wojtas, Yari Carlomagno, Jonathon P Sens, Silvia S Kang, Tanner D Jensen, John D Fryer

Acta Neuropathol Commun· December 2020

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